Drug
Methylene Blue clinical trials
Also written Methylthioninium Chloride, ProvayBlue, CI-52015 and TRx0014.
Counted the way a researcher would: Methylene Blue with its salts, dosage forms, brands and biosimilars. Looking for a trial to join? Including related medicines shows more you could take part in.
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Keep track of what changes. Save the Methylene Blue studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
70 studies that test it; most in 2016 (8); 1 more planned to start later
| Year | Studies |
|---|---|
| 2003 | 1 |
| 2004 | 4 |
| 2006 | 2 |
| 2007 | 2 |
| 2009 | 1 |
| 2011 | 1 |
| 2012 | 3 |
| 2013 | 1 |
| 2014 | 2 |
| 2015 | 2 |
| 2016 | 8 |
| 2017 | 3 |
| 2018 | 3 |
| 2019 | 7 |
| 2020 | 7 |
| 2021 | 5 |
| 2022 | 2 |
| 2023 | 2 |
| 2024 | 3 |
| 2025 | 6 |
| 2026 | 5 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 7 · Other 64
Ain Shams University (3) · Fondazione Epatocentro Ticino (2) · Fudan University (2) · The University of Texas Health Science Center at San Antonio (2) · Heidelberg University (2) · TauRx Therapeutics Ltd (2) · University of Oxford (2) · Chinese University of Hong Kong (2)
Often tested with
Tested in the same studies.
Amodiaquine (2) · Photodynamic Therapy (1) · Methenamine (1) · Fanasil, pyrimethamine drug combination (1) · Artesunate (1) · Ropivacaine (1) · Iso-sulfan blue (1) · Nitric Oxide (1)
Studies
Open first, then newest update. How each study uses Methylene Blue is read from its arms, and is right about nine times in ten.
Testing it · 71
- Assessing the Feasibility of Using Methylene Blue in Identifying Ureters During Colorectal SurgeryNot yet recruitingPhase 4Chinese University of Hong KongNCT07861815Written as Intravenous Methylene Blue
- Randomised Controlled Trial of Fluorescent Urography Using Intravenous Methylene Blue Compared to White Light Alone in Left-sided Colorectal SurgeryNot yet recruitingPhase 4Chinese University of Hong KongNCT07835932Written as Intravenous Methylene blue
- Local Methylene Blue Injection for Prevention of Anastomotic Leakage and Permanent Stoma After Low Anterior Resection for Rectal CancerRecruitingPhase 2Peking University Cancer Hospital & InstituteNCT07833319Written as methylene blue injection
- Methylene Blue Treatment of Chronic Hepatitis B Virus InfectionRecruitingPhase 2Fondazione Epatocentro TicinoNCT06887036Written as Methylene Blue
- A Phase 2 Study of Methylene Blue Photodynamic Therapy for Treatment of Breast AbscessesNot yet recruitingPhase 2University of RochesterNCT07179003Written as Methylene Blue
- Topical Methylene Blue-Photodynamic Therapy (MB-PDT) for Burn Wound InfectionNot yet recruitingEarly Phase 1University of OklahomaNCT07494773Written as Methylene Blue
- Early Methylene Blue in the Microhemodynamics of Septic PatientsRecruitingPhase 2/3Centro de Estudos e Pesquisa em Emergencias Medicas e Terapia IntensivaNCT07264543Written as Methylene blue infusion
- Efficacy of Methylene Blue Photodynamic Therapy for Treatment of Deep Tissue AbscessesNot yet recruitingPhase 2University of RochesterNCT06052956Written as Methylene Blue
- Adjunctive Methylene Blue for Immunotherapy-related CRS and ICANS: Phase I StudyRecruitingPhase 1Institute of Hematology & Blood Diseases Hospital, ChinaNCT07169487Written as Methylene Blue
- Efficacy of Methylene Blue Plus Ropivacaine for Post-Hemorrhoidectomy Pain.Not yet recruitingPhase 4The Affiliated Hospital of Putian UniversityNCT07164807Written as Methylene Blue (0.3%) with Ropivacaine Hydrochloride (0.75%)
- The Effect of Methylene Blue Infiltrating Injection on Anal Pain After Milligan-Morgan Surgery: a Randomized Controlled Clinical StudyEnrolling by invitationPhase 3The Second Affiliated Hospital of Anhui University of Traditional Chinese MedicineNCT06660680Written as Methylene Blue
- Intravenous Methylene Blue for Treating Refractory Neonatal Septic ShockNot yet recruitingPhase 2/3Post Graduate Institute of Medical Education and Research, ChandigarhNCT06306001Written as Methylene Blue
- The Effect of Combination Therapy of Oral MB and PRP-FG in Patients With Non-healing Diabetic Foot UlcerRecruitingEarly Phase 1Mashhad University of Medical SciencesNCT05850611Written as Methylene Blue
- Dysfunction of Respiratory Enzymes in Adults With Mental Illness (DREAM)CompletedNot applicableKing's College LondonNCT07866833Written as Methylene Blue
- Identification of Sentinel Lymph Nodes With Methylene Blue and IsotopeCompletedNot applicableUniversity Hospital, Strasbourg, FranceNCT00314405Written as Methylene blue (1%)
- Methylene Blue for the Prevention of Hypotension During HemodialysisCompletedPhase 2Federal University of São PauloNCT05092165Written as Methylene Blue
- Adjunctive Methylene Blue in Septic ShockCompletedPhase 3Dr. Shannon M. FernandoNCT06900140Written as Methylene Blue
- Local Injection Methylene Blue Combined With Radiation in HNSCC PatientsActive, not recruitingEarly Phase 1China Medical University HospitalNCT07435415Written as Methylene Blue (50 mg/10ml)
- Methylene Blue for the Treatment of Septic ShockCompletedPhase 3Northern Jiangsu People's HospitalNCT06532240Written as Methylene Blue
- Methylene Blue-Enhanced Ultrafiltration Improves Outcomes After Cardiopulmonary BypassCompletedPhase 2University of Sao PauloNCT07212842Written as Methylene Blue
See all 71 studies that test Methylene Blue →
Given in every arm · 4 — Methylene Blue is usual care beside what is tested
- Methylene Blue in Total Knee Arthroplasty (TKA)RecruitingPhase 1University of MiamiNCT07324954Written as Methylene Blue 10 MG/ML (intra-articular application)
- Safety and Feasibility Study of Methylene Blue Photodynamic Therapy to Sterilize Deep Tissue Abscess CavitiesCompletedPhase 1University of RochesterNCT02240498Written as Methylene Blue
- Sentinel Lymph Node Biopsy in Breast Cancer Surgery Using ICGCompletedNot applicableChinese Academy of SciencesNCT03579979Written as Methylene Blue
- Sentinel and/or Axillary Lymph Node Biopsy With or Without Axillary Reverse Mapping in Reducing Incidence and Severity of Arm Lymphedema in Stage 0-2 Patients.TerminatedPhase 2University of Southern CaliforniaNCT01276054Written as methylene blue
As the comparator · 2 — what is tested is compared with Methylene Blue
- Use of Indocyanine Green Cholangiography and Methylene Blue to Detect Postoperative Biliary Fistula After HepatectomyCompletedPhase 3Centre Hospitalier Universitaire, AmiensNCT01847612Written as methylene blue
- Methylene Blue vs Cyanokit for Intraoperative Vasoplegic Syndrome in Liver Transplant PatientsCompletedPhase 4Mayo ClinicNCT04054999Written as Methylene Blue
Codes
What other systems call Methylene Blue · ClinicalTrials.gg INT007816
- MeSH (NLM) D008751Methylene BlueConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) T42P99266KMETHYLENE BLUEConfirmed FDA, NLM, Wikidata
- RxNorm 6878One source FDA
- Wikidata Q72490419methylene blue trihydrateConfirmed FDA, NLM, Wikidata
- Wikidata Q72490421Methylene Blue trihydrateConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C644Methylene BlueOne source FDA
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D008751 | Methylene Blue | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | T42P99266K | METHYLENE BLUE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 6878 | — | One source FDA |
| Wikidata | Q72490419 | methylene blue trihydrate | Confirmed FDA, NLM, Wikidata |
| Wikidata | Q72490421 | Methylene Blue trihydrate | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C644 | Methylene Blue | One source FDA |
Also registered as methylene blue anhydrous (UNII 8NAP7826UB · RxNorm 2198975).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.