An observational study in Periodontal Disease and Periodontal Surgery, sponsored by Ohio State University. Recruiting at 1 site in United States. Open to participants aged 21 Years to 75 Years. Per ClinicalTrials.gov, last updated 2026-09-11.
Sponsored by Ohio State University · Observational
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Among 91 studies in Periodontal Diseases with a site in United States — 15 open to participants now, 17 under way, none of them phase 3. Periodontal Diseases · United States.
Among the 91 studies in Periodontal Diseases with a site in United States, this one is the 24th largest by planned enrollment of the 30 observational ones that give a count, is one of 3 that started in 2026, is one of 30 observational ones, reaches primary completion later than 10 of the 15 other live ones, and was the 90th registered.
867 studies on the registry are indexed under Periodontal Diseases; 189 are open to participants now.
Browse Periodontal Diseases studies →15 of the 91 studies in Periodontal Diseases with a site in United States are open now. Recruiting first, the newest first:
University of California, San Francisco · Sites in United States
Ages 18+ · Women only
Medical University of South Carolina · Sites in United States
Ages 18+ · Healthy volunteers
State University of New York at Buffalo · Sites in United States
Ages 18–70 · Healthy volunteers
The University of Texas Health Science Center at San Antonio · Sites in United States
Ages 18–18 · Healthy volunteers
University of Minnesota · Sites in United States
Ages 18+ · Healthy volunteers
A study can be open while its sites in United States have not opened yet or have stopped. Only those recruiting at a site in United States →
Of the 101 Periodontal Diseases studies recruiting now, 47 (47%) set no upper age limit and 42 (42%) stop at 75 or younger; 5 take children under 18; 58 take healthy volunteers.
This study: 21 Years to 75 Years · all sexes · no healthy volunteers.
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91 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 4 · Phase 2 7 · Phase 3 7 · Phase 4 6
First in 1998; this study’s year is marked. 3 started in 2026.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 30 is below the median of 99 across 302 observational studies indexed under Periodontal Diseases.
Median enrollment 60 across the 61 interventional studies, 89 across the 30 observational. Of the 66 that completed or were terminated, 18 (27%) have results posted.
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18 of 91 have an industry lead sponsor. The 10 most frequent:
Ohio State University is the lead sponsor of 663 studies on the registry; 148 are open to participants now.
Of its 67 completed or terminated interventional studies of FDA-regulated products, 49 (73%) have results posted.
Ohio State University has 1 study filed under Periodontal Diseases — fewer than ten, so there is no comparison to draw.
7 of the studies in Periodontal Diseases with a site in United States that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07095556Medical University of South CarolinaImpact of Nd:YAG Laser Photobiostimulation on Healing of Gingiva | 2026-12 |
| NCT06948162University of MinnesotaExploration of the Utility of Dental-dedicated MRI for Dentistry | 2027-03-31 |
| NCT06149585Case Western Reserve UniversityChanges in Microbial Status From Dentate, Edentulous and After Dental Implant Placement | 2027-05-01 |
| NCT07054008The University of Texas Health Science Center at San AntonioMicrosurgery and Periodontal Healing | 2027-05-31 |
| NCT07468929Ohio State UniversitySerum Inflammatory Protein Concentration During Dental Treatment | 2027-06 |
Add all 7 to your calendar (.ics) → With an account.
Among the 91 studies in Periodontal Diseases with a site in United States, from their registry updates:
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The goal of this observational study is to study the molecular markers of stress in blood samples from people who are having periodontal surgery. The main question it aims to answer are:
Periodontal disease is a chronic inflammatory disease and is associated with pro-inflammatory mediators such as increased levels of Tumor necrosis factor-alpha (TNF-a), Interleukin (IL)-17, IL-6, IL-1beta, and C-reactive protein (CRP) within gingival tissues as well as gingival crevicular fluid. IL-17 is a pro-inflammatory cytokine that promotes recruitment of neutrophil and stimulates host cells to produce other pro-inflammatory factors such as IL-1, IL-6, TNF-, and CRP that are related to the acute phase of vascular inflammation. There is evidence supporting increased levels of these mediators at diseased tooth site. Based on the severity of local periodontal inflammation, some increase in circulatory serum levels of these mediators is also expected. However, the information on how periodontal treatment performed around teeth may affect circulatory serum levels of these biologic markers is limited. Thus, this study aims to assess the acute and subacute molecular systemic effects of extensive (more than 3 adjacent teeth) periodontal/peri-implant surgery and compare them with the possible effects of non-surgical therapy (control) in patients treated for generalized form of the periodontitis
Study population will be created from the general patient population that is referred to The Ohio State University College of Dentistry's Advanced Training in Periodontology clinics or already established patients in our clinics. These are adult patients suffering from gum disease, losing teeth due to disease and/or having disease around their dental implants. There will be two groups: Control group 1 will be recruited from the patients who have already received active treatment to control their disease and are now in periodontal maintenance program (regular cleaning). Control group 2 will be recruited from patients who are receiving non-surgical deep cleaning (debridement under local anesthesia) and Test group will be recruited from patients who are treatment planned for periodontal/peri-implant surgical interventions.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Recruited from patients who have already received active treatment to control their disease and are now in periodontal maintenance program (regular cleaning).
Other: Blood samples for inflammatory markers · Procedure: Periodontal maintenance
Recruited from patients who are receiving non-surgical deep cleaning (debridement under local anesthesia)
Other: Blood samples for inflammatory markers · Procedure: Non-surgical deep cleaning
Recruited from patients who are treatment planned for periodontal/peri-implant surgical interventions.
Other: Blood samples for inflammatory markers · Procedure: periodontal surgery
Blood samples will be obtained before the start of the procedure, the midpoint of the procedure, and the end of the procedure.
Periodontal/peri-implant surgical interventions, with or without IV sedation, as based on treatment needs
Regular cleaning to maintain health after surgical treatment for periodontal disease
Debridement under local anesthesia, as based on treatment needs
Serum CRP concentration (pg/ml)
The investigators will study CRP concentration (pg/ml) in circulatory inflammatory mediator content during dental treatment by drawing peripheral blood samples, isolating serum and running a protein assay to detect inflammatory protein content in concentration (pg/ml) level.
Time frame: Immediately prior to procedure; approximately midway through the procedure; immediately after procedure ends;
Seum IL-1 concentration (pg/ml)
The investigators will measure serum IL-1 concentration (pg/ml) in blood samples obtained immediately before, during and immediately after the dental procedure.
Time frame: During dental procedure intervention
Serum TNF concentration (pg/ml)
The investigators will measure serum TNF concentration (pg/ml) during dental procedure.
Time frame: Blood samples will be obtained immediately before, during and immediately after dental procedure intervention.
Sedation Effect
The investigators will record whether the surgical procedure was performed under sedation, and will study the possible differential effect of sedation on low level circulatory inflammation.
Time frame: Immediately prior to procedure; approximately midway through the procedure; immediately after procedure ends;
Tissue change (mm)
Tissue change (mm), obtained as part of standard of care, will be collected from the participant's electronic health care record.
Time frame: Approximately 30 days after the procedure
Plan to share: No
No publications or documents are linked to this record.
Started Jul 2026 (actual). Primary completion is estimated for Jun 2027, 11 months after the start.
Of 79 non-industry observational studies under Periodontal Diseases, half reached primary completion within 13 months of starting (the median), counting those still running; a quarter within 7 and three quarters within 30. This study's planned 11 months is below that.
Counting every sponsor, half of 83 studies reached it within 13 months; a quarter within 7 and three quarters within 32.
How these figures are worked out, and which studies are left out of them.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
No contact was published for this record. The registry link below has the sponsor’s details.
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