Chronic Periodontitis clinical trials
The registry lists 377 studies for Chronic Periodontitis across more than 10 countries. 21 are recruiting or about to start. 324 of them are mainly about Chronic Periodontitis (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-21.
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Who runs them
Government Dental College and Research Institute, Bangalore (25) · Cairo University (17) · Meenakshi Ammal Dental College and Hospital (11) · Tatyasaheb Kore Dental College (9) · University of Sao Paulo (8) · Postgraduate Institute of Dental Sciences Rohtak (6) · Ataturk University (6) · University of Campinas, Brazil (5)
What is being tested here
Drugs under test in Chronic Periodontitis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 8
- Nov 2026Profiling Gingival Crevicular Fluid β-Catenin Level With 8-OHdG and Total Antioxidants Capacity During Healing of Periodontal Pockets: A 3-month Clinical Trial · Zeyad Nazar
- Feb 2027Vector® System vs Mini-Five Curettes in Non-Surgical Periodontal Therapy · Hacettepe University
- May 2027Changes in Microbial Status From Dentate, Edentulous and After Dental Implant Placement · Case Western Reserve University
- Jun 2027Clinical and Radiographic Evaluation of Doxycycline and Atorvastatin Loaded Chitosan Nanoparticles as an Adjunctive to Scaling and Root Planning in the Management of Chronic Periodontitis. A Randomized Controlled Clinical Trial. · Fayoum University
- Jul 2027HbA1c Screening in Dental Care and Primary Care Referral in Patients With Advanced Periodontitis · Region Skane
- Sep 2027The Effect Of Enamel Matrix Derivatives On Gingival Tissue Thickness · The University of Texas Health Science Center at San Antonio
- Sep 2027Evaluation of Changes in Oral Health-related Quality of Life During the Treatment of Periodontitis. · University Hospital, Clermont-Ferrand
- Oct 2027Evaluation of Masticatory Performance in Patients With Periodontitis · University Hospital, Clermont-Ferrand
Who these studies take
Of the 13 Chronic Periodontitis studies recruiting now, 7 (54%) set no upper age limit and 5 (38%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 4 (31%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 11 (85%) | 11 (85%) |
| 30 | 12 (92%) | 12 (92%) |
| 40 | 12 (92%) | 12 (92%) |
| 50 | 12 (92%) | 12 (92%) |
| 65 | 11 (85%) | 11 (85%) |
| 75 | 9 (69%) | 9 (69%) |
| 85 | 7 (54%) | 7 (54%) |
Across all 377 studies, recruiting or not: 69% stop at 75 or younger and 57% at 65; 5% take children; 2% are for women only and 3% for men only; 58% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Chronic Periodontitis studies take
Of 21 phase 4 interventional studies under Chronic Periodontitis, half reached primary completion within 14 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 4 | 14 mo7–24 · 21 studies | — | — |
| Interventional, no phase | 15 mo10–24 · 89 studies | — | 15 mo10–24 · 88 studies |
| Observational | 9 mo5–17 · 21 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting1
- Evaluation of Masticatory Performance in Patients With PeriodontitisOct 16, 2026NCT07665489
Studies
Recruiting first, then most recently updated. Showing 50 of 377. Browse all 377 → or search them.
- Evaluation of Masticatory Performance in Patients With PeriodontitisRecruitingNCT076654891 country
- Evaluation of Changes in Oral Health-related Quality of Life During the Treatment of Periodontitis.Not yet recruitingNCT078680421 country
- HbA1c Screening in Dental Care and Primary Care Referral in Patients With Advanced PeriodontitisRecruitingNCT07688278Not applicable1 country
- Changes in Microbial Status From Dentate, Edentulous and After Dental Implant PlacementRecruitingNCT061495851 country
- Clinical and Radiographic Evaluation of Doxycycline and Atorvastatin Loaded Chitosan Nanoparticles as an Adjunctive to Scaling and Root Planning in the Management of Chronic Periodontitis. A Randomized Controlled Clinical Trial.Not yet recruitingNCT07634341Phase 41 country
- Impact of Periodontal Inflammation on Allostatic LoadRecruitingNCT06978712Not applicable1 country
- Profiling Gingival Crevicular Fluid β-Catenin Level With 8-OHdG and Total Antioxidants Capacity During Healing of Periodontal Pockets: A 3-month Clinical TrialNot yet recruitingNCT07596667Not applicable
- Vector® System vs Mini-Five Curettes in Non-Surgical Periodontal TherapyRecruitingNCT07452640Not applicable1 country
- Microbiological and Clinical Effects of Pre- and Probiotics in Non-Surgical Periodontal TherapyRecruitingNCT07443410Not applicable1 country
- 3-Month Clinical Trial of Liquid S-PRF in Periodontal Debridement for Periodontitis Stages II-IVRecruitingNCT07293962Phase 21 country
- The Effect Of Enamel Matrix Derivatives On Gingival Tissue ThicknessRecruitingNCT07053969Not applicable1 country
- Metformin Versus Chlorhexidine Gel as Adjuncts to Scaling and Root Planing in Stage II Grade B PeriodontitisNot yet recruitingNCT07215156Not applicable
- B Cell Functions in PeriodontitisRecruitingNCT028332851 country
- Full Mouth Ultrasonic Debridement Carried Out With Either Piezoelectric or Magnetostrictive DeviceRecruitingNCT06934291Not applicable1 country
- A Chitosan Brush and Enamel Matrix Derivative for Non-surgical Treatment of FurcationsRecruitingNCT06684769Not applicable1 country
- Impact of Smoking on Salivary Interleukin (IL)-39, IL-41, IL-1β, TNF-α Levels in Periodontal DiseaseNot yet recruitingNCT06528522
- Assessment of Masticatory Performance in PeriodontitisNot yet recruitingNCT064260691 country
- Contribution of an Antiviral Drug (Valaciclovir) in the Treatment of Generalized Periodontitis (Stage III or IV and Grade A, B or C): Prospective, Randomized and Double Blind Clinical TrialRecruitingNCT05902208Phase 31 country
- Clinical Effects of Limosilactobacillus Reuteri Probiotics as an Adjunct to the Treatment of PeriodontitisRecruitingNCT05734274Not applicable1 country
- Transplantation of Bone Marrow Mesenchymal Stromal Cells for Periodontal RegenerationEnrolling by invitationNCT05975892Phase 1/21 country
- The Link Between Periodontitis, Smoking and Oral CancerNot yet recruitingNCT040472121 country
- Garlic Product Impact on Periodontitis (GPIP)CompletedNCT03492723Not applicable1 country
- Salivary Mitofusin-1 Levels in Periodontitis: Associations With Disease Severity, Smoking, and Treatment ResponseCompletedNCT07262606Not applicable1 country
- Utilization of a Videoscope in Periodontal RegenerationActive, not recruitingNCT05275192Not applicable1 country
- Non-surgical Periodontal Treatment in Smokers on SIRT-1, NLRP3 Inflammasome and LncRNAsCompletedNCT063517221 country
- Comparison of Clinical and Radiographic Parameters in the Application of Cross-linked Hyaluronic Acid 1.8% and Enamel Matrix Derivative in Periodontal Regeneration.CompletedNCT04274244Phase 41 country
- Study on Treatment Results and Bone Changes After Replanting Severely Affected Teeth - A Before-and-After Study.CompletedNCT06893107Not applicable1 country
- Clinical and Radiograhic Evaluation of NIPSA With and Without Allograft Plus Platelet Rich Fibrin in the Treatment of Intraosseous Defects in Stage III Periodontitis PatientsCompletedNCT04444063Not applicable1 country
- Clinical Efficacy of NST With Adjunctive Local Delivery of Ozonated Olive Versus Curcumin Gel in Stage II Grade B Periodontitis.CompletedNCT07184268Not applicable1 country
- Impact of Periodontitis Grading on Peri-Implant Clinical and Bone Health: A 60-Month Prospective StudyCompletedNCT07671456
- Photodynamic Therapy as an Adjunct to Non-Surgical Periodontal Therapy in Stage II PeriodontitisCompletedNCT07609888Not applicable1 country
- Minimally-invasive Non-surgical Therapy of Intrabony DefectsWithdrawnNCT03741374Not applicable4 countries
- Use of the xCELLigence System for Quantification of Bacterial Biofilm's Real Time Formation and Antibiotics Selection.CompletedNCT03863249Phase 41 country
- Metabolic Regeneration Registry for Periodontal Health (20-Patient Cohort).CompletedNCT075386611 country
- Evaluation of Indian Gooseberry/ Amla in the Management of Chronic PeriodontitisCompletedNCT07531823Not applicable1 country
- Clinical and Microbiological Evaluation of Laser Therapy in the Treatment of Periodontal Disease in Stages III and IVCompletedNCT06426550Not applicable1 country
- The Importance of Prostaglandin and Nitric Oxide Synthesis in Apical PeriodontitisCompletedNCT06023901Not applicable1 country
- MIST Versus M-MIST for the Treatment of Intrabony DefectsActive, not recruitingNCT06058923Not applicable1 country
- Cofilin-2 (rs80358250) and Lactoferrin (rs1126478) Polymorphism and Protein Levels With Non Surgical Periodontal Therapy in Periodontitis Patients With and Without CHDActive, not recruitingNCT07353606Not applicable1 country
- Antimicrobial Peptides in PeriodontitisCompletedNCT02793453Not applicable1 country
- Comparing Inflammatory Markers in Patients With and Without Depression With Chronic PeriodontitisActive, not recruitingNCT03553095Not applicable1 country
- Treatment of Intrabony Defect in Patient With Periodontitis Stage III by Using I-PRF and XenograftActive, not recruitingNCT07261878Not applicable1 country
- Role of NLRP6 in Chronic PeriodontitisCompletedNCT064000691 country
- Analysis of the Impact of Contemporary Subgingival Debridement Techniques on Immunological Biomarkers in Gingival Crevicular FluidCompletedNCT072431451 country
- i-PRF & Root Surface BiomodificationCompletedNCT07207668Not applicable1 country
- Comparing the Efficacy of Metronidazole and Minocycline Gels for the Treatment of Diabetic Periodontitis PatientsCompletedNCT06027151Not applicable1 country
- Evaluation of Coconut Oil Mouth Rinse on Periodontal ParametersCompletedNCT07175090Early Phase 11 country
- Bovine Bone With or Without Concentrated Growth Factor in the Treatment of Chronic PeriodontitisCompletedNCT07108790Not applicable1 country
- Influence of Periodontal Diseases on Vascular Parameters in Patients Suffering of HypertensionTerminatedNCT023948601 country
- Novel PAradigm to Improve Inflammatory Burden in ESRD (rePAIR): A Pilot and Feasibility Randomized Controlled TrialCompletedNCT03241511Not applicable1 country