An observational study in Periodontal Diseases, IBD and Dysbiosis, sponsored by University of Turin, Italy. Recruiting at 1 site in Italy. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2026-10-30.
Sponsored by University of Turin, Italy · Observational
Periodontitis and inflammatory bowel disease have been associated by meta-epidemiologic evidence, although their mechanistic connection needs to be further explored. Oral-gut axis is implicated in the pathogenesis of several chronic inflammatory conditions, but to date no studies have evaluated the impact of periodontal treatment on gut ecology. Thus, the present observational prospective study is aimed at investigating the effect of conventional periodontal therapy on the gut microbiome and parameters of systemic inflammation of patients diagnosed with inflammatory bowel disease.
867 studies on the registry are indexed under Periodontal Diseases; 189 are open to participants now.
This study's planned enrollment of 30 is below the median of 99 across 302 observational studies indexed under Periodontal Diseases.
Browse Periodontal Diseases studies →University of Turin, Italy is the lead sponsor of 214 studies on the registry; 35 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Adult patients diagnosed with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, who also present with periodontitis and are eligible to receive periodontal therapy.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Subgingival instrumentation with ultrasonic devices and curettes of all periodontal pockets in 2 or 4 appointments
Changes in microbiome alpha diversity measured from stool samples at 3 months
Taxonomic and functional variation of gut bacteria after treatment
Time frame: Baseline and 90 days
2. Changes in microbiome alpha diversity measured from saliva samples at 3 months
Taxonomic and functional variation of salivary bacteria after treatment
Time frame: Baseline and 90 days
Changes in mean clinical attachment level (CAL) at 3 months
Variation in CAL after therapy assessed using a millimetre marked manual periodontal probe at 6 sites per tooth element
Time frame: Baseline and 90 days
Changes in periodontal pocket depth (PPD) at 3 months
Variation in PPD after therapy assessed using a millimetre marked manual periodontal probe at 6 sites per tooth element
Time frame: Baseline and 90 days
Changes in full mouth bleeding score (FMBS) at 3 months
Variation in the percentage of bleeding sites after therapy assessed by gentle probing at 6 sites per tooth element
Time frame: Baseline and 90 days
Changes in plasma inflammatory and immunological biomarkers
Changes in plasmatic levels of cytokines and other inflammatory biomarkers (IL-1, TNF-a, IL-6, CPR)
Time frame: Baseline and 90 days
Plan to share: Undecided
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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