Pain, Intractable clinical trials
The registry lists 91 studies for Pain, Intractable across more than 10 countries. 17 are recruiting or about to start. Per ClinicalTrials.gov, last updated 2026-09-25.
Status
- Completed
- 38
- Recruiting
- 13
- Terminated
- 13
- Status unknown
- 11
- Withdrawn
- 7
- Not yet recruiting
- 3
Phase
- Phase 2
- 11
- Phase 3
- 8
- Phase 4
- 8
- Phase 1
- 5
- Early Phase 1
- 1
Where
- United States
- 42
- France
- 10
- Spain
- 8
- Canada
- 6
- Germany
- 5
- Belgium
- 5
Who runs them
Abbott Medical Devices (7) · MedtronicNeuro (6) · Boston Scientific Corporation (5) · Flowonix Medical (3) · Janssen Pharmaceutical K.K. (2) · Chulalongkorn University (2) · Guy's and St Thomas' NHS Foundation Trust (2) · University of Texas Southwestern Medical Center (2)
Studies
Recruiting first, then most recently updated. Showing 50 of 91 — search for more.
- Post Market Evaluation of Real World Outcomes and Durability to Support Implantable Inceptiv™ Spinal Cord Stimulation TherapyRecruitingNCT075074222 countries
- Managing Pain Using Optimized Sequences by Adjusting Parameters With Independent Current ControlRecruitingNCT07190807Not applicable1 country
- Periganglionic Resiniferatoxin for the Treatment of Intractable Pain Due to Cancer-induced Bone PainNot yet recruitingNCT02522611Phase 1/21 country
- Resiniferatoxin to Treat Severe Pain Associated With Advanced CancerRecruitingNCT00804154Phase 11 country
- A Study of the Safety and Tolerability of GA in the Treatment of Patients With Refractory Neuropathic PainRecruitingNCT06596681Early Phase 11 country
- Single Arm, Monocentric, Pilot Feasibility Study on an Interactive Virtual Reality Program in 20 Complex In-clinic Palliative Care PatientsNot yet recruitingNCT07545928Not applicable1 country
- MRI Evaluation of Spinal Cord Edema After CT-Guided Percutaneous Cordotomy in Cancer Pain PatientsNot yet recruitingNCT074000551 country
- Sensory Spinal Cord StimulationRecruitingNCT07095036Not applicable1 country
- Observational Study of Ketamine Infusions for the Treatment of Chronic PainEnrolling by invitationNCT054770041 country
- OP2C : Prialt® Observatory in Clinical PracticeRecruitingNCT043214083 countries
- Treatment of Opioid-refractory Pain (WHO Level III) by Pituitary RadiosurgeryRecruitingNCT02637479Not applicable1 country
- Fluoroscopic-Guided Bipolar Versus Monopolar Pulsed Radiofrequency for Refractory Trigeminal NeuralgiaRecruitingNCT06779578Not applicable1 country
- Medullary Stimulation for the Treatment of Refractory Neck Pain (S2M)RecruitingNCT05398003Not applicable1 country
- Clinical Effect of LG Medipain for Managing Chronic Pain DisordersRecruitingNCT05165901Not applicable1 country
- Effectiveness and Safety of Implantable Intrathecal Systems for Refractory Pain in Spain (INTRATHECAL-RENASED)RecruitingNCT059700811 country
- Transcranial Direct-current Stimulation (tDCS) Efficacy in Refractory Cancer Pain.RecruitingNCT04683172Not applicable1 country
- APP-based Precise Management System of Chronic Intractable PainRecruitingNCT05761392Not applicable1 country
- Patients Referred to the Chronic Pain Unit for Palliative Treatment With Ozone Therapy Between 2022 and 2025Active, not recruitingNCT054177371 country
- Study to Evaluate Neuromodulation Subject Experience With Contemporary Spinal Cord Stimulation (SCS) Modalities for Chronic PainTerminatedNCT057755101 country
- Methadone as an Alternative Treatment for Children Underdoing HSCTSuspendedNCT06940570Phase 31 country
- Impact of DuoTherm Compared to TENS on Pain and Disability With Acute and Chronic Low Back PainCompletedNCT04494698Not applicable1 country
- Identification of Outcome Predictors and Stratification of Responder Profiles Implanted With Spinal Cord Stimulation. An AI-based-pathway & Algorithmic Approach to Treat Failed Back Surgery Syndrome PatientsCompletedNCT04587674Not applicable1 country
- Use of Ketamine in Severe Pain SyndromesCompletedNCT065373751 country
- Spinal Cord Stimulation vs. Medical Management for Low Back Pain (DISTINCT)CompletedNCT04479787Not applicable1 country
- Study to Evaluate Automated Intensity Management in Patients Undergoing a BSC SCS Temporary TrialCompletedNCT04909593Not applicable1 country
- Comparison of DTM™ SCS Therapy Combined With Conventional Medical Management (CMM) to CMM Alone in the Treatment of Intractable Back Pain Subjects Without Previous History of Lumbar Spine SurgeryCompletedNCT06442410Not applicable4 countries
- Efficacy of Ketamine in Post Anesthesia Recovery RoomCompletedNCT047010081 country
- Sham-Controlled RCT on 10kHz High-Frequency Spinal Cord Stimulation for Chronic Neuropathic Low Back Pain (Modulate-LBP)TerminatedNCT03470766Not applicable1 country
- Identifying Biomarkers and Changes in Cerebrospinal Fluid Collected Pre and Post Spinal Cord Stimulation in Subjects Suffering From Chronic Refractory Pain ConditionsTerminatedNCT03986255Not applicable1 country
- Study to Assess Epidural Resiniferatoxin for the Treatment of Intractable Pain Associated With Advanced CancerSuspendedNCT05067257Phase 21 country
- Pilot Study of Sedation With Propofol in Refractory Pains Due to Care in Palliative Care UnitCompletedNCT02198404Phase 41 country
- The True Efficacy of Burst Spinal Cord Stimulation in the Management of Intractable Low Back Pain (TRU-BURST)WithdrawnNCT06030284Not applicable2 countries
- Compare the Efficacy and Safety of Intranasal Esketamine in Chronic Opioid Refractory PainWithdrawnNCT04666623Phase 21 country
- Prometra Post-Approval StudyCompletedNCT01854229Not applicable1 country
- Investigating Biological Targets, Markers, and Intervention for Chronic PainCompletedNCT04625504Not applicable1 country
- Safety and Activity Study of Intrathecally Administered Ziconotide for Neuropathic Pain in Patients With CancerStatus unknownNCT00996983Phase 21 country
- How Does Mindfulness Meditation Buffer the Negative Effects of Pain and Suffering in the COVID-19 World? (Pain Sample)CompletedNCT04602286Not applicable1 country
- Spinal Cord Stimulation in the Treatment of Chronic, Intractable Pain Using the Nalu™ Neurostimulation SystemCompletedNCT04503109Not applicable1 country
- High-Density Spinal Cord Stimulation for the Treatment of Chronic Intractable Pain PatientsTerminatedNCT03318172Not applicable1 country
- Pain Blocking During Drug Administration or Blood Collection With NeedlesCompletedNCT011669061 country
- Effect of Electroacupuncture on Refractory Pain in Juvenile Rheumatoid Arthritis: Randomized Controlled TrialStatus unknownNCT05504382Not applicable1 country
- Improving Outcomes and Lowering Costs by Integration of Primary Care Providers and Pain Medicine Physicians for Pain PtsTerminatedNCT02484937Not applicable1 country
- Post-market, Randomized, Controlled, Prospective Study Evaluating Intrathecal Pain Medication (IT) Versus Conventional Medical Management (CMM) in the Non-cancer, Refractory, Chronic Pain PopulationCompletedNCT04096391Not applicable1 country
- Patient Controlled Intrathecal Analgesia With Bupivacaine for Chronic Low Back PainCompletedNCT02886286Phase 41 country
- Phase 3 Study to Assess Resiniferatoxin vs Standard of Care for the Treatment of Intractable Cancer PainWithdrawnNCT04572776Phase 3
- Pawsitive Impacts of Therapy Dog VisitsCompletedNCT04727749Not applicable1 country
- Lixivaptan in a Single Subject With Intractable Pain Due to Polycystic Kidney DiseaseNo longer availableNCT037171811 country
- Intermittent vs. Continuous Dorsal Root Ganglion StimulationStatus unknownNCT04727216Not applicable1 country
- Multi-center Prospective Study Determining the Sustainability of Pain Relief and Psychosocial and Functional Responses When Utilizing a Multiple Waveform Enabled NeurostimulatorCompletedNCT03082261Not applicable7 countries
- Transitioning to a Valve -Gated Intrathecal Drug Delivery SystemStatus unknownNCT04312685Not applicable1 country