An observational study in Pain, Postoperative, Ketamine Adverse Reaction and Pain, Refractory, sponsored by University of Alberta. Completed at 1 site in Canada. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-09-19.
Sponsored by University of Alberta · Observational
Observational study to assess efficacy of IV ketamine bolus when used in the post anesthesia recovery unit for uncontrolled pain despite use of opioids.
In this observational study, the investigators will monitor all patients with significant pain after any non-cardiac surgical intervention at the University of Alberta Hospital.
After receiving an adequate dose of potent opioids (hydromorphone, morphine), the participants will receive up to 0,2-0,25 mg/kg IV ketamine bolus. In our center these boluses are given with 10-20mg increments.
The adequate dose of opioids will be determined by the attending anesthesiologist, depending on what patients received intraoperatively and on their comorbidities.
Pain scores will be assessed before and after administration of this drug. The incidence of any side effect after ketamine administration will be documented.
The following patients will be identified and recruited at the post-anesthesia care unit:
Adult patients undergoing non-cardiac surgery at University of Alberta Hospital meeting the following criteria:
Adult patients undergoing non cardiac surgery at University of Alberta Hospital meeting the following criteria:
Exclusion Criteria:
Patients with significant pain despite receiving narcotics in PACU will receive a bolus dose of IV ketamine to assess its efficacy for pain score reduction. Bolus doses are given by 10mg IV increments, to reach approximate dose of 0,25mg/kg.
Drug: Ketamine
IV ketamine - 10mg bolus may be repeated repeated 2-3 times depending on clinical judgement
Reduction in pain score after ketamine use in PACU
The Numeric Rating Scale (NRS-11) is an 11-point scale for patient self-reporting of pain. It is what is used most often in our recovery room for pain assessment. A score of 0/10 means no pain, and 10/10 means worst pain.
Time frame: in the immediate post-operative period in recovery room
Incidence of side effects after ketamine use
Time frame: in the immediate post-operative period in recovery room
Plan to share: No
This study is completed, as verified in Jul 2022. You cannot join it, but the record below documents what was studied.
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University of Alberta