Opioid antagonists clinical trials
A class of medicines: the studies that test any of its 7 members, each study once. Members are as MeSH files each medicine’s actions, and as the NCI Thesaurus classes newer ones. In MeSH: Narcotic Antagonists.
Get an email when these change. Save the opioid antagonists studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Medicines in this class
Studies that test each. A study of two counts under both, and once above.
Studies by the year they started
608 studies that test it; most in 2016 (38); 5 more planned to start later
| Year | Studies |
|---|---|
| 1992 | 1 |
| 1993 | 2 |
| 1995 | 3 |
| 1996 | 4 |
| 1997 | 5 |
| 1998 | 5 |
| 1999 | 4 |
| 2000 | 9 |
| 2001 | 5 |
| 2002 | 9 |
| 2003 | 16 |
| 2004 | 9 |
| 2005 | 14 |
| 2006 | 27 |
| 2007 | 37 |
| 2008 | 27 |
| 2009 | 30 |
| 2010 | 23 |
| 2011 | 34 |
| 2012 | 28 |
| 2013 | 29 |
| 2014 | 27 |
| 2015 | 27 |
| 2016 | 38 |
| 2017 | 34 |
| 2018 | 21 |
| 2019 | 13 |
| 2020 | 19 |
| 2021 | 35 |
| 2022 | 21 |
| 2023 | 12 |
| 2024 | 18 |
| 2025 | 5 |
| 2026 | 17 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 185 · Other 440
Bausch Health Americas, Inc. (39) · Yale University (28) · Alkermes, Inc. (27) · National Institute on Drug Abuse (NIDA) (22) · University of Pennsylvania (22) · AstraZeneca (19) · New York State Psychiatric Institute (15) · Orexigen Therapeutics, Inc (13)
Studies
Open first, then newest update. How each study uses a medicine is read from its arms, and is right about nine times in ten. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing one of them · 625
- Low Dose Naltrexone Therapy for Complex Regional Pain SyndromeEnrolling by invitationPhase 4Hospital for Special Surgery, New YorkNCT06306157Written as Low dose naltrexone
- The Study of Brave-LC LDN Treatment TrialNot yet recruitingPhase 3National Institute of Allergy and Infectious Diseases (NIAID)NCT07916259Written as naltrexone
- A Study of the Feasibility, Safety and Tolerability of Aticaprant as Adjunctive Treatment in Participants With SchizophreniaRecruitingPhase 1Janssen Research & Development, LLCNCT07615426Written as Aticaprant
- Sedation and Guided Education for Depression StudyNot yet recruitingNot applicableStanford UniversityNCT06705270Written as IV naloxone
- Opioids and Social Support Enhanced Extinction EffectsEnrolling by invitationEarly Phase 1University of California, Los AngelesNCT04166071Written as Naltrexone
- LIFT: Life Improvement TrialRecruitingPhase 2Brigham and Women's HospitalNCT06366724Written as Low-Dose Naltrexone
- A Pilot Study on the Efficacy of Oral Low Dose Naltrexone for VulvodyniaNot yet recruitingPhase 2University of FloridaNCT07862400Written as Low Dose Naltrexone
- Low-Dose Naltrexone For ME/CFS: Dose-FindingNot yet recruitingPhase 2University of Alabama at BirminghamNCT07285473Written as Low-Dose Naltrexone, 1.5mg
- Sex Differences in Trauma, Inflammation and Brain Function and the Implications for Treatment Efficacy in Alcohol Use DisorderRecruitingPhase 4Milky KohnoNCT06426303Written as Naltrexone
- Combination Therapy for Alcohol Use DisorderNot yet recruitingPhase 2Johns Hopkins UniversityNCT07249554Written as Naltrexone (oral tablets)
- Evaluation of the O'Neil Long Acting Naltrexone Implant in Opioid Dependent PersonsNot yet recruitingPhase 2Go Medical Industries Pty LtdNCT05382091Written as naltrexone implant
- Evaluating Buprenorphine/Naloxone Microdosing vs. Standard Dosing in Emergency DepartmentsRecruitingPhase 2/3University of British ColumbiaNCT04893525Written as Buprenorphine/naloxone
- Naloxone for Opioid Associated Out of Hospital Cardiac ArrestNot yet recruitingPhase 2University of California, San FranciscoNCT06251609Written as Naloxone 2 MG
- Chronic Widespread Pain in HIV: Novel Mechanisms and TherapeuticsRecruitingNot applicableFlorida International UniversityNCT04787848Written as Relistor Injectable Product
- A Study Comparing Oral Buprenorphine and Injectable Buprenorphine for the Treatment of Opioid Use DisorderRecruitingPhase 4VA Office of Research and DevelopmentNCT04375033Written as Sublingual buprenorphine with naloxone
- Development of a MHBC Intervention for Weight Loss and Smoking Cessation for Pre-Bariatric Surgery PatientsNot yet recruitingPhase 1Medical University of South CarolinaNCT07224087Written as Naltrexone Hydrochloride
- Naloxone for In-Hospital Cardiac ArrestNot yet recruitingPhase 2/3Region SkaneNCT07806565Written as naloxone
- Low Dose Naltrexone (LDN) for Management of Fatigue in Prostate Cancer Patients on Androgen Deprivation Therapy (ADT)RecruitingPhase 2University of ArkansasNCT07224009Written as Naltrexone
- Predicting Response to Naltrexone With Eye Tracking in Gaming DisorderRecruitingPhase 2University of Sao PauloNCT04649892Written as Naltrexone
- Emergency Department-Initiated Medications for Alcohol Use DisorderRecruitingPhase 3Yale UniversityNCT05827159Written as Naltrexone Pill
See all 625 studies that test one of the opioid antagonists →