Hypersensitivity, Immediate clinical trials
The registry lists 82 studies for Hypersensitivity, Immediate across more than 10 countries. 7 are recruiting or about to start. 32 of them are mainly about Hypersensitivity, Immediate (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-23. Counting its 25 narrower conditions too, such as Asthma: 9,055 studies, 1,282 open.
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Who runs them
Allergy Therapeutics (17) · National Institute of Allergy and Infectious Diseases (NIAID) (8) · Ellodi Pharmaceuticals, LP (4) · Assistance Publique - Hôpitaux de Paris (3) · DBV Technologies (3) · Columbia University (2) · AstraZeneca (2) · Merz North America, Inc. (2)
What is being tested here
Drugs under test in Hypersensitivity, Immediate studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Epinephrine | 1 | 0 | 2 |
| Grass MATA MPL | 0 | 1 | 4 |
| APT-1011 | 0 | 3 | 3 |
| Benralizumab | 0 | 1 | 2 |
| Desloratadine | 0 | 2 | 2 |
| Abrocitinib | 0 | 2 | 2 |
| KP-001 | 0 | 0 | 1 |
| Tezepelumab | 0 | 0 | 1 |
| Icatibant | 0 | 0 | 1 |
| Dupilumab | 0 | 1 | 1 |
Drug classes tested here Antihistamines 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 3
- Dec 2026Effects of Inhaled Epinephrine on Systemic Allergic Reactions During Allergy Testing, Immunotherapy or Oral Challenges · Dr. George Luciuk
- Dec 2026Risk-stratified Testing for Safe Removal of Penicillin Allergy Labels · Deniz Göcebe
- May 2027Pharmacokinetics and Safety of a Single Dose of Epinephrine Nasal Spray in Paediatric Allergy Patients · Hikma Pharmaceuticals USA Inc.
Who these studies take
Of the 5 Hypersensitivity, Immediate studies recruiting now, 3 (60%) set no upper age limit and 2 (40%) stop at 75 or younger. 2 (40%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (40%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 4 (80%) | 4 (80%) |
| 30 | 4 (80%) | 4 (80%) |
| 40 | 4 (80%) | 4 (80%) |
| 50 | 4 (80%) | 4 (80%) |
| 65 | 4 (80%) | 4 (80%) |
| 75 | 3 (60%) | 3 (60%) |
| 85 | 3 (60%) | 3 (60%) |
Across all 82 studies, recruiting or not: 70% stop at 75 or younger and 60% at 65; 40% take children; 2% are for women only and 0% for men only; 21% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 11, 2026.
Newly registered1
Studies
Recruiting first, then most recently updated. Showing 50 of 82. Browse all 82 → or search them.
- Pharmacokinetics and Safety of a Single Dose of Epinephrine Nasal Spray in Paediatric Allergy PatientsNot yet recruitingNCT07891780Phase 21 country
- BREATHE: An Efficacy-implementation Trial Among Black Adults With Uncontrolled AsthmaRecruitingNCT05341726Not applicable1 country
- Effects of Inhaled Epinephrine on Systemic Allergic Reactions During Allergy Testing, Immunotherapy or Oral ChallengesRecruitingNCT07038746Phase 11 country
- Birth Cohort: Development of IgE Autoantibodies in Newborns With (High Risk of) Atopic DermatitisRecruitingNCT07316465Not applicable1 country
- Risk-stratified Testing for Safe Removal of Penicillin Allergy LabelsRecruitingNCT06755281Not applicable1 country
- Repertoire and Properties of Anti-drug Antibodies Involved in Immediate Hypersensitivity in the Operating RoomRecruitingNCT05420935Not applicable1 country
- Assessment of Er:YAG Laser for the Control of Hypersensitivity During Tooth Whitening With Hydrogen PeroxideNot yet recruitingNCT06538129Not applicable
- A Phase 1 Study of Cizutamig in IgE Mediated DiseasesWithdrawnNCT07408869Phase 11 country
- Tromsø Birch Rust Allergy Study. Allergy to Birch Rust, a Possible Explanation to Seasonal Airway Allergy During Autumn?CompletedNCT043228381 country
- Clinical Determinants and Perioperative Allergic Reactions (CADECAP Study)CompletedNCT039187721 country
- Pathogenesis of Physical Induced Urticarial SyndromesCompletedNCT008879391 country
- Head-to-Head Comparison Study Between Different FDA Registered Allergy Skin Test ApplicatorsCompletedNCT07400718Not applicable1 country
- Allergic Disease Onset Prevention StudyCompletedNCT05003804Phase 1/23 countries
- Expanded Access Protocol for Patients With Eosinophilic EsophagitisNo longer availableNCT050951161 country
- A Double-blind, Placebo-controlled, Parallel-group Study to Evaluate the Safety and Efficacy of Briquilimab in Participants With Allergic AsthmaTerminatedNCT06592768Phase 11 country
- Diagnosis and Physiopathology of Insulin AllergyCompletedNCT01407640Not applicable1 country
- Standardised Drug Provocation Testing in Perioperative HypersensitivityCompletedNCT06065137Not applicable1 country
- Phase 1 Crossover Study Evaluating the Safety, Tolerability, and Pharmacokinetics of KP001 in Healthy Adult VolunteersCompletedNCT06963411Phase 11 country
- Effect of Benralizumab in Atopic DermatitisCompletedNCT03563066Phase 21 country
- 24-Week Induction Study of APT-1011 in Adult Subjects With Eosinophilic Esophagitis (EoE) (FLUTE 3)CompletedNCT05634746Phase 32 countries
- Effects of Inhaled Epinephrine on Systemic Allergic Reactions During Allergy Testing Immunotherapy or Oral ChallengesCompletedNCT06445374Phase 11 country
- Indoor Air Quality for Black Adults With Uncontrolled AsthmaCompletedNCT056853811 country
- An Efficacy and Safety Study of Desloratadine (MK-4117) in Japanese Participants With Chronic Urticaria (MK-4117-201)CompletedNCT01916967Phase 3
- Efficacy and Safety Study of Desloratadine (MK-4117) in Japanese Participants With Eczema/Dermatitis and Dermal Pruritus (MK-4117-202)CompletedNCT01916980Phase 3
- ADP101 for Oral Immunotherapy in Food-Allergic Children and AdultsCompletedNCT04856865Phase 1/21 country
- Norwegian Birch Rust Allergy StudyCompletedNCT056618121 country
- Open-label Extension Study of ADP101TerminatedNCT05243719Phase 1/21 country
- The Impact of an Evidence-based Myth-busting Information Intervention on Maternal Food Allergy Related Quality of Life, Anxiety and Self-efficacyCompletedNCT06221540Not applicable1 country
- Efficacy and Safety APT-1011 in Adolescent Subjects With Eosinophilic Esophagitis (EoE) - A Sub-Study of the FLUTE-2 TrialCompletedNCT05083312Phase 32 countries
- Efficacy and Safety APT-1011 in Adult Subjects With Eosinophilic Esophagitis (EoE) (FLUTE-2)CompletedNCT04281108Phase 33 countries
- Kenota 1 CWS Method Comparison Validation StudyCompletedNCT057026711 country
- The Use of Penicillin Allergy Clinical Decision Rule to Enable Direct Oral Penicillin ChallengeCompletedNCT04454229Not applicable3 countries
- Follow-up of the VIPES Study to Evaluate Efficacy and Safety of Viaskin Peanut in Adults and ChildrenCompletedNCT01955109Phase 24 countries
- Study to Evaluate Tezepelumab on Airway Inflammation in Adults With Uncontrolled Asthma (CASCADE)CompletedNCT03688074Phase 25 countries
- A Study of the Safety and Effectiveness of Benralizumab to Treat Patients With Severe Uncontrolled Asthma.CompletedNCT03170271Phase 314 countries
- Efficacy and Safety of Several Doses of Viaskin Peanut in Adults and Children With Peanut AllergyCompletedNCT01675882Phase 25 countries
- Study to Investigate Efficacy and Safety of PF-04965842 in Subjects Aged 12 Years and Over With Moderate to Severe Atopic Dermatitis With the Option of Rescue Treatment in Flaring SubjectsCompletedNCT03627767Phase 321 countries
- Evaluation of Safety and Tolerability of Tyrosine Adsorbed Ragweed Pollen Allergoid With MPL (Monophosphoryl Lipid A)WithdrawnNCT00109759Phase 11 country
- Asthma Data Innovation Demonstration ProjectCompletedNCT02162576Not applicable1 country
- Assessment of the Contribution of Monophosphoryl Lipid A (MPL) to a Grass Pollen Allergy VaccineCompletedNCT00133146Phase 21 country
- Investigation of Safety+Efficacy of Different Doses of RagweedMATAMPL;Assessment of Residual Allergenicity Using Skin Prick TestCompletedNCT00258635Phase 21 country
- Retrospective Study of Immediate Hypersensitivity (IHS) Reactions to Platinum Salts in the University Hospital of NancyStatus unknownNCT049207211 country
- Open-label, Single-arm Study to Assess the Pharmacokinetics, Safety, and Tolerability of a Single Subcutaneous Dose of Icatibant in Healthy Japanese VolunteersCompletedNCT02045264Phase 11 country
- Different Doses of Tyrosine Adsorbed Grass Pollen Allergoid With Monophosphoryl Lipid A (MPL) in Patients Sensitized to Grass PollenCompletedNCT00133159Phase 21 country
- Different Doses of Tyrosine Adsorbed Tree Pollen Allergoid With Monophosphoryl Lipid A (MPL) in Patients Sensitized to Tree PollenCompletedNCT00118612Phase 21 country
- Study Evaluating Efficacy and Safety of PF-04965842 and Dupilumab in Adult Subjects With Moderate to Severe Atopic Dermatitis on Background Topical TherapyCompletedNCT03720470Phase 318 countries
- Investigation of Efficacy and Safety of Tree MATAMPL,Tree MATA, and Placebo in Patients With Birch-Induced Seasonal Allergic RhinitisTerminatedNCT00387478Phase 21 country
- Safety and Pharmacokinetics of GNR-038 in Healthy VolunteersCompletedNCT04557319Phase 11 country
- A Randomized, Double-Blind Placebo-Controlled Peanut Sublingual Immunotherapy TrialCompletedNCT00580606Phase 1/21 country
- The Significance of Blood-tryptase and c-Kit Mutation in Insect Venom ImmunotherapyCompletedNCT025038001 country