Eosinophilic Esophagitis clinical trials
The registry lists 235 studies for Eosinophilic Esophagitis across more than 10 countries. 53 are recruiting or about to start. 201 of them are mainly about Eosinophilic Esophagitis (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-13.
Get an email when these change. Save the Eosinophilic Esophagitis studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Who runs them
Mayo Clinic (24) · Children's Hospital Medical Center, Cincinnati (13) · University of North Carolina, Chapel Hill (9) · University of Colorado, Denver (8) · Regeneron Pharmaceuticals (7) · National Institute of Allergy and Infectious Diseases (NIAID) (7) · Ann & Robert H Lurie Children's Hospital of Chicago (6) · Allakos Inc. (6)
What is being tested here
Drugs under test in Eosinophilic Esophagitis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Dupilumab | 4 | 3 | 11 |
| Budesonide | 1 | 7 | 18 |
| Fluticasone | 1 | 4 | 11 |
| Cord blood | 1 | 0 | 1 |
| Upadacitinib | 1 | 0 | 1 |
| Alpha 1-Antitrypsin | 1 | 0 | 1 |
| AK002 | 0 | 4 | 6 |
| Cendakimab | 0 | 2 | 4 |
| APT-1011 | 0 | 3 | 4 |
| Esomeprazole | 0 | 1 | 3 |
Drug classes tested here Corticosteroids 2 open · Proton pump inhibitors (PPIs) 7
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Dec 2026Once Daily Versus Twice Daily Budesonide Orodispersible Tablets for Induction of Remission in EoE · Phase 3 · Dr. Falk Pharma GmbH
- Nov 2026Indiana University Gastrointestinal Motility Diagnosis Registry · Indiana University
- Dec 2026A Trial to Evaluate EP-104GI in Adults With Eosinophilic Esophagitis (EoE). · Eupraxia Pharmaceuticals Inc.
- Dec 2026Changes in Esophageal Distensibility With Proton Pump Inhibitors in Patients With Esophageal Eosinophilia: A Pilot Study · Indiana University
- Jan 2027Esophageal String Test in Eosinophilic Esophagitis · University of Colorado, Denver
- Jan 2027Dupilumab Therapy for EGIDs · Children's Hospital of Fudan University
- Jan 2027National, Multicenter, Retrospective, Prospective Study to Evaluate Pediatric Gastrointestinal Eosinophilic Disorders · Fondazione IRCCS Policlinico San Matteo di Pavia
- Apr 2027A Study to Investigate the Efficacy and Safety of NSI-8226 in Adults With Eosinophilic Esophagitis · Uniquity One (UNI)
- May 2027Efficacy of Low-Dose Topical Steroids in Maintaining Remission of Eosinophilic Esophagitis in Children · Ann & Robert H Lurie Children's Hospital of Chicago
- Jun 2027A Non-interventional Observational Study to Assess Long-term Efficacy and Safety of Dupilumab for the Treatment of Patients (>= 12 Years) With Eosinophilic Esophagitis Under Real-world-conditions in Germany · Sanofi
Who these studies take
Of the 42 Eosinophilic Esophagitis studies recruiting now, 12 (29%) set no upper age limit and 27 (64%) stop at 75 or younger. 27 (64%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 7 (17%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 24 (57%) | 24 (57%) |
| 18 | 34 (81%) | 34 (81%) |
| 30 | 25 (60%) | 25 (60%) |
| 40 | 25 (60%) | 25 (60%) |
| 50 | 25 (60%) | 25 (60%) |
| 65 | 24 (57%) | 24 (57%) |
| 75 | 17 (40%) | 17 (40%) |
| 85 | 15 (36%) | 15 (36%) |
Across all 235 studies, recruiting or not: 58% stop at 75 or younger and 45% at 65; 52% take children; 0% are for women only and <1% for men only; 16% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Eosinophilic Esophagitis studies take
Of 24 phase 2 interventional studies under Eosinophilic Esophagitis, half reached primary completion within 24 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 24 mo15–28 · 24 studies | — | — |
| Phase 3 | 34 mo17–37 · 16 studies | — | — |
| Interventional, no phase | 34 mo24–41 · 23 studies | — | — |
| Observational | 49 mo22–120 · 55 studies | — | 49 mo22–120 · 52 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 235. Browse all 235 → or search them.
- The Esophageal String Test as a Diagnostic Screening Tool for Eosinophilic Esophagitis Among Africans With Dysphagia in Mali and the United StatesRecruitingNCT07027826Not applicable2 countries
- Natural History and Genetics of Food Allergy and Related ConditionsRecruitingNCT025048531 country
- A Trial of Upadacitinib for Non-responsive Eosinophilic EsophagitisRecruitingNCT07588568Phase 21 country
- A Study of Dupilumab in Small Children With an Allergic Condition of the Esophagus (Food Pipe): Eosinophilic EsophagitisRecruitingNCT07112378Phase 31 country
- Molecular Basis of Food AllergyEnrolling by invitationNCT018323241 country
- A Non-interventional Observational Study to Assess Long-term Efficacy and Safety of Dupilumab for the Treatment of Patients (>= 12 Years) With Eosinophilic Esophagitis Under Real-world-conditions in GermanyRecruitingNCT066958971 country
- The Potential Role of Compounds Derived From Ultra-processed Foods in Pathogenesis of Eosinophilic EsophagitisRecruitingNCT060932041 country
- Compassionate Use or Expanded Access of DupilumabAvailableNCT04776694
- Impact of Body Positioning on EndoFLIP Measurements: A Comparative Study of Supine and Left Lateral Decubitus PositionsRecruitingNCT07780981Not applicable1 country
- Elimination Diet Strategies and Histologic Remission in Children With Eosinophilic Gastrointestinal DisordersRecruitingNCT077797721 country
- The DiNAM-EoE-C Study: Esophageal Distensibility and Novel Assessment of Motility in Eosinophilic EsophagitisEnrolling by invitationNCT077084671 country
- Utility of Mucosal Impedance Device in Chronic Esophageal Disorders:RecruitingNCT072275061 country
- Characteristics and Inflammatory Markers in Children With Eosinophilic Esophagitis (EoE)RecruitingNCT039808861 country
- Natural History of Eosinophilic Esophagitis in Adult and Pediatric PopulationRecruitingNCT076146331 country
- Indiana University Gastrointestinal Motility Diagnosis RegistryRecruitingNCT045065931 country
- Prevalence and Description of FIRE (Food Induced Immediate Response of the Esophagus) in the Pediatric Population With Eosinophilic EsophagitisRecruitingNCT069721471 country
- Pediatric Eosinophilic Esophagitis (pedEoE): Effect of Allergen Heat Denaturation on EoE Remission: a Pilot TrialRecruitingNCT06381219Not applicable1 country
- Comparison of Eohilia With Dupixent on Esophagus Diameter in Patients With Eosinophilic Esophagitis.Enrolling by invitationNCT07358234Early Phase 11 country
- Trial of Partial Enteral Nutrition With Dairy Free Diet in Eosinophilic EsophagitisRecruitingNCT07234825Not applicable1 country
- PRospective Registry of Esophageal MotilityRecruitingNCT075067461 country
- Study of Gastric Motility in Eosinophilic GastritisRecruitingNCT052294321 country
- A Trial to Evaluate EP-104GI in Adults With Eosinophilic Esophagitis (EoE).RecruitingNCT05608681Phase 1/26 countries
- Eosinophilic Gastrointestinal Disorders RegistryRecruitingNCT051995321 country
- EoE Food Test Pilot StudyNot yet recruitingNCT07023380Not applicable1 country
- Institutional Registry of Rare DiseasesRecruitingNCT065737231 country
- Zemaira Eosinophilic Esophagitis Pilot StudyRecruitingNCT05485155Phase 21 country
- Dupilumab Therapy for EGIDsRecruitingNCT072578351 country
- Changes in Esophageal Distensibility With Proton Pump Inhibitors in Patients With Esophageal Eosinophilia: A Pilot StudyRecruitingNCT033126861 country
- OMEGA: Outcome Measures in Eosinophilic Gastrointestinal Disorders Across the AgesRecruitingNCT025231181 country
- EDN and Eosinophilic EsophagitisRecruitingNCT06387030Not applicable1 country
- Prospective Registry of EoSinophilic esOphagitisRecruitingNCT064433461 country
- Trans-Cervical and Trans-abdominal Ultrasound for Monitoring Esophageal Thickness in Eosinophilic EsophagitisNot yet recruitingNCT07057986Not applicable
- Local Clinical and Immunological Responses in Eosinophilic Esophagitis (EoE) Patients, Role of Mucosal Barrier Function and Type II InflammationRecruitingNCT070129281 country
- An Intervention Study to Improve Therapeutic Compliance in Adult Patients With Eosinophilic Esophagitis.RecruitingNCT05730933Not applicable1 country
- Umbilical Cord Blood Therapy in a Child With Eosinophilic Duodenitis and Autism Spectrum Disorder: a Case StudyNot yet recruitingNCT06995274Not applicable
- Esophageal String Test Monitoring to Monitor Eosinophilic Esophagitis During Oral ImmunotherapyRecruitingNCT063899941 country
- Eosinophilic Esophagitis: Towards Improved ManagementRecruitingNCT069918811 country
- Tolerability of Baked Dairy Protein in Eosinophilic Esophagitis Patients With Cow Milk Protein TriggerEnrolling by invitationNCT06756581Not applicable1 country
- Tolerability of Goat Milk Protein in Eosinophilic Esophagitis Patients With Cow Milk Protein TriggerRecruitingNCT05180578Not applicable1 country
- Dupilumab Versus Topical Corticosteroid Effectiveness - Comparison in the Treatment of Stenotic EoERecruitingNCT06705387Phase 21 country
- A Registry for the Food Allergy CommunityRecruitingNCT046533241 country
- Effect of Dupilumab on the Muscle Function of the Esophagus (food Pipe) in Participants with Eosinophilic Esophagitis (EoE)RecruitingNCT06665971Phase 41 country
- National, Multicenter, Retrospective, Prospective Study to Evaluate Pediatric Gastrointestinal Eosinophilic DisordersRecruitingNCT052199031 country
- Targeted Elimination Diet in EoE Patients Following Identification of Trigger Nutrients Using Confocal Laser EndomicroscopyRecruitingNCT05695456Phase 1/21 country
- Fibrostenotic Eosinophilic Esophagitis: Assessment ToolsRecruitingNCT024531261 country
- Outcome of Children With Eosinophilic EsophagitisNot yet recruitingNCT06190080Not applicable1 country
- Sensory Processing Issues in Eosinophilic EsophagitisRecruitingNCT061877531 country
- Eosinophilic Oesophagitis Assessment With String TestingRecruitingNCT06159218Not applicable1 country
- Monocentric Retrospective Observational Study for Validation of Meta-analysis of the Metatrascryptome and Transcriptome of Eosynophyl EsophagitisNot yet recruitingNCT060715851 country
- Validation in French of a Quality of Life Questionnaire for Patients With Eosinophilic Esophagitis in PediatricsRecruitingNCT059000111 country