An observational study in Hypersensitivity, Immediate, Insect Bites and Stings and Mastocytosis, sponsored by Meir Medical Center. Completed at 1 site in Israel. Open to participants aged 4 Years to 75 Years. Per ClinicalTrials.gov, last updated 2019-08-20.
Sponsored by Meir Medical Center · Observational
The investigators wish to evaluate the association between tryptase values as well as c-Kit mutation and adverse effects in the course of immunotherapy. The investigators also intend to assess the effect of immunotherapy on tryptase levels.
According to the presently available reports there is an association between systemic allergic responses to hymenoptera venom and elevated tryptase levels or c-Kit mutation. The presence of these findings may imply the existence of mast cell activation syndrome or mastocytosis. Therefore, baseline tryptase evaluation has become standard evaluation in patients with systemic responses. Meir Medical Center is the only hospital in Israel in which tryptase can be measured. Consequently, the Meir Clinic has accumulated considerable data with regards to tryptase levels in subjects with allergy to hymenoptera venom. The investigators wish to evaluate the association between tryptase values as well as c-Kit mutation and adverse effects in the course of immunotherapy. The investigators also intend to assess the effect of immunotherapy on tryptase levels.
82 studies on the registry are indexed under Hypersensitivity, Immediate; 7 are open to participants now.
This study's enrollment of 159 is close to the median of 159 across 11 observational studies indexed under Hypersensitivity, Immediate.
Browse Hypersensitivity, Immediate studies →Meir Medical Center is the lead sponsor of 401 studies on the registry; 26 are open to participants now.
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The population will include all the subjects undergoing venom immunotherapy at the Clinic of Allergy and Clinical Immunology, Meir Medical Center.
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The study group will include all the subjects receiving routine venom immunotherapy at the Meir Medical Center Allergy Clinic.
The association between tryptase values/c-Kit mutation and immunotherapy adverse events will be evaluated using blood sample analysis and patient medical records.
Time frame: up to 12 months
The association between tryptase values/c-Kit mutation and severity of index sting event will be evaluated using blood sample analysis and patient medical records.
Time frame: up to 12 months
The record gives a start of Aug 2015, a primary completion of Feb 2019 and a completion of Feb 2019. It does not say whether these dates are actual or estimated.
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This study is completed, as verified in Aug 2019. You cannot join it, but the record below documents what was studied.
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