Drug class
Histamine Antagonists clinical trials
A class of medicines: the studies that test any of its 45 members, each study once. Members are as MeSH files each medicine’s actions, and as the NCI Thesaurus classes newer ones.
Keep track of what changes. Save the histamine antagonists studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesMedicines in this class
Studies that test each. A study of two counts under both, and once above.
- Pyrilamine
- 2
- Cinnarizine
- 2
- Naphazoline
- 2
- Brompheniramine
- 2
- Antazoline
- 2
- Tesmilifene
- 2
- Chlorphenesin carbamate
- 1
- Suplatast tosilate
- 1
- Tripelennamine
- 1
And 5 more, each tested in fewer studies.
Studies by the year they started
626 studies that test it; most in 2009 (40); 3 more planned to start later
| Year | Studies |
|---|---|
| 1995 | 1 |
| 1999 | 2 |
| 2000 | 5 |
| 2001 | 5 |
| 2002 | 28 |
| 2003 | 20 |
| 2004 | 19 |
| 2005 | 26 |
| 2006 | 36 |
| 2007 | 30 |
| 2008 | 35 |
| 2009 | 40 |
| 2010 | 35 |
| 2011 | 36 |
| 2012 | 27 |
| 2013 | 35 |
| 2014 | 25 |
| 2015 | 16 |
| 2016 | 12 |
| 2017 | 20 |
| 2018 | 15 |
| 2019 | 18 |
| 2020 | 17 |
| 2021 | 23 |
| 2022 | 21 |
| 2023 | 21 |
| 2024 | 22 |
| 2025 | 17 |
| 2026 | 19 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 386 · Other 260
Organon and Co (35) · Alcon Research (24) · UCB Pharma (23) · Pfizer (18) · Dr. Reddy's Laboratories Limited (17) · Sanofi (15) · Faes Farma, S.A. (14) · GlaxoSmithKline (12)
Studies
Open first, then newest update. How each study uses a medicine is read from its arms, and is right about nine times in ten.
Testing one of them · 646
- A Single and Multiple Ascending Dose Study of EPX-100 in Healthy Adult ParticipantsRecruitingPhase 1EpygenixNCT07879170Written as EPX-100
- An Efficacy and Safety Study of Clemizole HCl in Patients With Lennox-Gastaut SyndromeRecruitingPhase 3EpygenixNCT05066217Written as Clemizole HCl
- A Study to Evaluate Investigational Agents With or Without Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to Programmed Cell Death 1 Protein (PD-1)/ Programmed Cell Death Ligand 1 (PD-L1) Treatment (MK-3475-06B)RecruitingPhase 1/2Merck Sharp & Dohme LLCNCT05319730Written as Antihistamine
- Metronomic Temozolomide With Dexbrompheniramine for Recurrent High-Grade Glioma/GlioblastomaNot yet recruitingPhase 1/2University of NebraskaNCT07859059Written as Dexbrompheniramine
- Comparing Standard-Dose and High-Dose Cetirizine for Acute UrticariaRecruitingNot applicableUniversity of PhayaoNCT07236372Written as Cetirizine 10 mg once daily
- Alternate Pre-med in Anti-Cluster of Differentiation 20 (CD20) Pilot ProjectNot yet recruitingPhase 3University of MiamiNCT07472413Written as Cetirizine
- DV Plus Toripalimab With Cetirizine and Mecobalamin Pretreatment in Patients With Locally Advanced Unresectable or Metastatic Bladder CancerNot yet recruitingPhase 1Sun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityNCT07853053Written as Cetirizine
- IKS014 in Advanced Solid Tumors That Express HER2RecruitingPhase 1Iksuda Therapeutics Ltd.NCT05872295Written as IKS014
- Multiple Adjunct Therapies to Improve Immunotherapy Treatment in Patients With Locally Advanced or Metastatic Melanoma or Advanced Hepatocellular CancerNot yet recruitingPhase 2University of Southern CaliforniaNCT07836712Written as Desloratadine
- Impact of the Antihistamine Desloratadine on the Quality of Life and Dysmenorrhea in Patients With EndometriosisNot yet recruitingPhase 2Medical University of ViennaNCT07821320Written as Desloratadine
- A Study to Evaluate the Preliminary Efficacy and Safety of Terfenadine in Patients With Relapsing-Remitting Multiple SclerosisRecruitingPhase 2Chuan QinNCT07827716Written as Terfenadine
- Effect and Safety of Fexofenadine Hydrochloride vs Placebo in Patients With Acute Myocardial Infaction: A Randomized Clinical TrialRecruitingPhase 2Second Affiliated Hospital, Zhejiang University, School of MedicineNCT06548204Written as Fexofenadine Hydrochloride
- A SMART Approach to Evaluating the Benefits of Common Prescription and OTC Medications for InsomniaRecruitingPhase 4University of PennsylvaniaNCT07542756Written as Diphenhydramine, 25 mg
- A Study of EPX-100 (Clemizole Hydrochloride) in Participants With Dravet SyndromeRecruitingPhase 3EpygenixNCT04462770Written as Clemizole HCl
- Diphenhydramine as an Adjunct to Moderate Sedation for Procedural First Trimester AbortionsRecruitingPhase 4University of RochesterNCT07542730Written as Diphenhydramine
- Optimizing Ancillary Therapies With Immune Checkpoint Inhibitors for Solid Tumors (OAT ICI)RecruitingPhase 2Val AdamsNCT07661459Written as Loratadine
- The Impact of Fexofenadine Hydrochloride on the Prognosis of Patients Post-Acute Myocardial InfarctionRecruitingPhase 3Second Affiliated Hospital, Zhejiang University, School of MedicineNCT07381803Written as Fexofenadine 60 Mg Oral Tablet
- Ebastine for Adjuvant Treatment of Tumor Budding-Positive Liver Cancer After SurgeryNot yet recruitingPhase 4Second Affiliated Hospital of Xi'an Jiaotong UniversityNCT07734766Written as Ebastine
- Neonatal White Matter Injury Trial (WRAP)RecruitingPhase 1Bridget LaMonica Ostrem, M.D., Ph.D.NCT07688746Written as Clemastine fumarate
- Assessing Changes in Multi-parametric MRI in MS Patients Taking Clemastine Fumarate as a Myelin Repair TherapyRecruitingPhase 1/2University of California, San FranciscoNCT05359653Written as Clemastine Fumarate
See all 646 studies that test one of the histamine antagonists →
Codes
What other systems call Histamine Antagonists · ClinicalTrials.gg INT007614
- MeSH (NLM) D006633Histamine AntagonistsOne source ClinicalTrials.gov
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D006633 | Histamine Antagonists | One source ClinicalTrials.gov |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.