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Headache Disorders clinical trials

The registry lists 145 studies for Headache Disorders across more than 10 countries. 37 are recruiting or about to start. 50 of them are mainly about Headache Disorders (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-03. Counting its 9 narrower conditions too, such as Migraine Disorders: 2,319 studies, 475 open.

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Status

Completed
81
Recruiting
28
Status unknown
16
Not yet recruiting
8
Terminated
6
Active, not recruiting
4

Phase

Phase 2
13
Phase 3
10
Phase 1
9
Phase 4
5

Where

United States
50
Turkey
18
Denmark
12
Spain
10
Italy
8
France
8

Who runs them

Danish Headache Center (8) · Hospital Clínico Universitario de Valladolid (5) · Norwegian University of Science and Technology (3) · University Hospital, Ghent (3) · Second Affiliated Hospital, School of Medicine, Zhejiang University (3) · Mayo Clinic (3) · Saglik Bilimleri Universitesi (2) · Ankara City Hospital Bilkent (2)

What is being tested here

Drugs under test in Headache Disorders studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

DrugOpenPhase 3All
Islet Amyloid Polypeptide202
Amitriptyline102
Ketamine111
Idebenone111
Propranolol013
Naltrexone002
Acetaminophen002
Botulinum toxin type A002
Bupivacaine001
Prazosin001

Coming up

3phase 3 studies under way
12studies finish main data collection within a year2 of them phase 3

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest, phase 3 first

Who these studies take

Of the 28 Headache Disorders studies recruiting now, 15 (54%) set no upper age limit and 11 (39%) stop at 75 or younger. 7 (25%) take children under 18. 1 (4%) are for women only and 0 (0%) for men only; 7 (25%) take healthy volunteers.

Recruiting studies that take each age, of 28
AgeWomenMen
106 (21%)6 (21%)
1826 (93%)25 (89%)
3025 (89%)24 (86%)
4025 (89%)24 (86%)
5024 (86%)24 (86%)
6523 (82%)23 (82%)
7518 (64%)18 (64%)
8517 (61%)17 (61%)

Across all 145 studies, recruiting or not: 56% stop at 75 or younger and 46% at 65; 22% take children; 6% are for women only and 1% for men only; 23% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Headache Disorders studies take

Of 43 interventional studies with no phase under Headache Disorders, half reached primary completion within 20 months of starting, counting those still running.

Start to primary completionEvery sponsorIndustryNon-industry
Interventional, no phase20 mo7–42 · 43 studies—20 mo7–42 · 41 studies
Observational23 mo15–… · 21 studies——

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 12, 2026.

Started recruiting1

Newly registered1

Studies

Recruiting first, then most recently updated. Showing 50 of 145. Browse all 145 → or search them.