An observational study in Chronic Daily Headache and Chronic Migraine, sponsored by Stanford University. Recruiting at 1 site in United States. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-07-23.
Sponsored by Stanford University · Observational
Study is aimed at determining why some patients with episodic headache proceed to chronic daily or near daily headaches. The Investigators seek to discover differences in brain anatomy and function, composition of cerebrospinal fluid, blood products, genetics, and patient phenotypes that might help explain this process.
The purpose of our study is to better understand disease processes and risk factors involved in onset of chronic daily headaches/Chronic Migraines. Further, The Investigators hopes to learn more about the etiology and disease mechanisms to optimize treatment strategies and determine prophylactic measures.
Participation in this research study, will include online questionnaires, a blood sample, a lumbar puncture, and a magnetic resonance imaging (MRI) scan without contrast to measure brain activity. Participant may select to participate in a magnetic resonance imaging (MRI) scan and/ or lumbar puncture. participating in atleast 3 procedures is required (blood draw, online questionnaires , MRI and/or Spinal Tap.
The study recruits participants with headache ( any type of headaches), and patients with no headaches ( or less than 2/year). Participants do not need to have a specified headache type. All participants are asked to complete an on-line survey to characterize a number of phenotypic features felt to be relevant by the Investigators. Three independent study groups (imaging, proteomics/genetics, and phenotyping) analyze data independently and stratify the data. Then, by group analysis, correlation among the different modalities is sought to identify features that distinguish common elements that might help elucidate features that could predict which patients with episodic headache are likely to progress to chronic, and which patients without headache might be at greater risk to develop new daily persistent headache.
Anybody above 18 years of age regardless of their race, gender will be able to participate in this study.
Exclusion Criteria:
*Any neurological condition, at the discretion of the Principal Investigator (PI)
Participants experiencing headache of any type more than twice per year but less than 15 days per month. No interventions
Participants experiencing headache more than 15 days per month for at least three consecutive months. No interventions
Participants reporting fewer than two headaches per year. No interventions
Prediction of chronification of headache
Brain Imaging, Phenotyping and Proteomics data will be combined to learn headache mechanisms.
Time frame: five years
Plan to share: No
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
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Stanford University