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Tension-Type Headache clinical trials

The registry lists 143 studies for Tension-Type Headache across more than 10 countries. 42 are recruiting or about to start. 87 of them are mainly about Tension-Type Headache (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-03.

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Status

Completed
75
Recruiting
20
Not yet recruiting
16
Status unknown
14
Active, not recruiting
5
Enrolling by invitation
5

Phase

Phase 3
13
Phase 2
11
Phase 4
5
Phase 1
1

Where

United States
20
Turkey
17
Spain
13
Denmark
9
China
8
Egypt
7

Who runs them

Danish Headache Center (8) · University of Valencia (6) · Cairo University (5) · NMP Medical Research Institute (3) · Second Affiliated Hospital, School of Medicine, Zhejiang University (2) · Duke University (2) · National and Kapodistrian University of Athens (2) · GlaxoSmithKline (2)

What is being tested here

Drugs under test in Tension-Type Headache studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

DrugOpenPhase 3All
Bupivacaine111
Magnesium Sulfate101
Acetaminophen101
Desvenlafaxine001
Nortriptyline001
Onabotulinum toxin A011
Botulinum toxin type A011
Sodium Chloride011
Amitriptyline001
Sumatriptan001

Drug classes tested here NSAIDs 3

Coming up

2phase 3 studies under way
9studies finish main data collection within a year1 of them phase 3

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

All 9, phase 3 first

Who these studies take

Of the 20 Tension-Type Headache studies recruiting now, 5 (25%) set no upper age limit and 13 (65%) stop at 75 or younger. 7 (35%) take children under 18. 3 (15%) are for women only and 0 (0%) for men only; 6 (30%) take healthy volunteers.

Recruiting studies that take each age, of 20
AgeWomenMen
104 (20%)4 (20%)
1816 (80%)15 (75%)
3016 (80%)14 (70%)
4016 (80%)14 (70%)
5016 (80%)14 (70%)
6512 (60%)11 (55%)
758 (40%)8 (40%)
857 (35%)7 (35%)

Across all 143 studies, recruiting or not: 73% stop at 75 or younger and 66% at 65; 15% take children; 9% are for women only and 0% for men only; 30% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Tension-Type Headache studies take

Of 49 interventional studies with no phase under Tension-Type Headache, half reached primary completion within 7 months of starting, counting those still running.

Start to primary completionEvery sponsorIndustryNon-industry
Interventional, no phase7 mo3–32 · 49 studies—7 mo3–32 · 49 studies

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 13, 2026.

Newly registered1

Studies

Recruiting first, then most recently updated. Showing 50 of 143. Browse all 143 → or search them.