Cluster Headache clinical trials
The registry lists 116 studies for Cluster Headache across more than 10 countries. 27 are recruiting or about to start. Per ClinicalTrials.gov, last updated 2026-09-23.
Status
- Completed
- 59
- Recruiting
- 19
- Terminated
- 14
- Status unknown
- 11
- Not yet recruiting
- 6
- Active, not recruiting
- 3
Phase
- Phase 3
- 19
- Phase 2
- 19
- Phase 1
- 8
- Phase 4
- 6
Where
- United States
- 35
- Denmark
- 20
- United Kingdom
- 18
- Germany
- 18
- France
- 15
- Netherlands
- 15
Who runs them
Danish Headache Center (6) · Autonomic Technologies, Inc. (6) · The University of Texas Health Science Center, Houston (5) · Leiden University Medical Center (5) · Norwegian University of Science and Technology (5) · Assistance Publique Hopitaux De Marseille (4) · Thomas Jefferson University (3) · Eli Lilly and Company (3)
Studies
Recruiting first, then most recently updated. Showing 50 of 116 — search for more.
- Yogabased Movements for Primary Headaches (Migraine and/or Cluster Headache) - YOURHEADRecruitingNCT07348783Not applicable1 country
- Italian Trigeminal Autonomic Cephalalgias Assessment StudyRecruitingNCT078127401 country
- A Pivotal Clinical Study to Evaluate the MySalvia System for the Treatment of Resistant MigraineRecruitingNCT07719608Not applicable1 country
- A First-in-human Study to Assess the Initial Safety, Tolerability, and Effectiveness of the ONSS Bilateral Occipital Nerve Field Stimulation System for the Prophylactic Treatment of Chronic Cluster Headache in Difficult-to-treat Subjects.RecruitingNCT07677137Not applicable1 country
- Efficacy, Safety and Tolerability of Low Sodium Oxybate for Nocturnal Cluster Headache AttacksNot yet recruitingNCT06950281Phase 2
- High- vs Standard-Dose Intravenous Magnesium for Acute HeadacheRecruitingNCT07779486Not applicable1 country
- Zavegepant Intranasal Spray for the Acute Treatment of Episodic Cluster HeadacheNot yet recruitingNCT07714369Phase 21 country
- Response to Combined Trigeminal and Occipital Nerve Stimulation for the Preventive Treatment in Chronic Cluster HeadacheRecruitingNCT07113470Not applicable1 country
- Clinical Trial of Endoscopically Guided Injection of Exparel (Bupivacaine) for the Treatment of Craniofacial PainRecruitingNCT04930887Phase 21 country
- Pain Biomarker StudyEnrolling by invitationNCT03511846Phase 11 country
- The Will Erwin Headache Research Center - Cluster Headache StudyRecruitingNCT029103231 country
- Repeated GON Injections in CCHRecruitingNCT05324748Phase 31 country
- nVNS for the Prevention and Treatment of Primary HeadacheRecruitingNCT06277063Not applicable1 country
- China Headache and Vertigo Registry StudyRecruitingNCT049399221 country
- LSD to Improve Cluster Headache Impact TrialRecruitingNCT05477459Phase 21 country
- Pulsed Radiofrequency Combined With Platelet-Rich Plasma Applied to the Sphenopalatine Ganglion in Treating Episodic Cluster HeadacheNot yet recruitingNCT068822781 country
- Efficacy of Light Therapy in Treatment of Chronic Cluster HeadacheRecruitingNCT06540651Not applicable1 country
- Lysergic Acid Diethylamide (LSD) as Treatment for Cluster HeadacheRecruitingNCT03781128Phase 21 country
- SPG Pulsed Radiofrequency for Chronic Cluster HeadacheRecruitingNCT06787677Not applicable1 country
- Botulinum Toxin Type A Blockade of the Sphenopalatine Ganglion in Treatment-refractory Chronic Cluster HeadacheRecruitingNCT03944876Phase 35 countries
- Quest to Analyze One Thousand Humans MeditatingEnrolling by invitationNCT065833951 country
- Role of Specific microRNAs in Cluster HeadacheRecruitingNCT065033281 country
- Resting State Functional Connectivity in Cluster HeadacheRecruitingNCT062067721 country
- A Close Examination of Patient Experiences in Cluster Headache Clinical ResearchNot yet recruitingNCT059782581 country
- Incidence of Intravascular (IV) Injection During Trigeminal Nerve BlocksRecruitingNCT044673981 country
- Detection of Local Field Potentials in the Ventral Tegmental Area of the Midbrain in Chronic Cluster Headache PatientsNot yet recruitingNCT058570981 country
- Civamide Nasal Solution for Cluster HeadacheNot yet recruitingNCT01341548Phase 3
- Yogabased Movements for Primary Headaches (Migraine and/or Cluster Headache) - YOURHEAD - a Pilot StudyActive, not recruitingNCT07292090Not applicable1 country
- Personalised Process-based Psychological Interventions for Paediatric HeadachesCompletedNCT07418723Not applicable1 country
- Cerebral Metabolism in Patients With Refractory Chronic Cluster Headache Treated by Occipital Nerve StimulationCompletedNCT02081482Not applicable1 country
- Ketamine + Magnesium for Chronic Cluster Headache (KETALGIA)CompletedNCT04814381Phase 41 country
- Osteopathic Manual Therapy (OMT) and Brain Structure and Function in Primary Headache Patients: A Pilot StudyCompletedNCT06841627Not applicable1 country
- REsponse to Combined SONS and ONS in Chronic Cluster headachEActive, not recruitingNCT05868044Not applicable1 country
- Nurse Intervention TrialTerminatedNCT06200480Not applicable1 country
- Sphenopalatine Ganglion Pulsed Radiofrequency Treatment OutcomesCompletedNCT07370142Not applicable1 country
- Cluster Headache Treatment SurveyCompletedNCT060118111 country
- Cluster Headache Treatment With RimegepantCompletedNCT05264714Phase 21 country
- Atrioventricular Block and Cluster Headache (SEVA)Active, not recruitingNCT04406259Phase 41 country
- A Research Study to Examine Cutaneous Allodynia and Cluster HeadacheCompletedNCT003298361 country
- High Dose Vitamin D Plus Multivitamin in the Prevention of Cluster HeadacheTerminatedNCT04570475Not applicable1 country
- Treatment of Chronic Cluster Headache with TENS and ONSCompletedNCT05023460Not applicable1 country
- Eptinezumab in Participants With Episodic Cluster HeadacheCompletedNCT04688775Phase 319 countries
- A 1-year Trial to Inform About Long-term Exposure to Eptinezumab in Participants With Chronic Cluster Headache (cCH)CompletedNCT05064397Phase 39 countries
- Bilateral Occipital Nerve Field Stimulation for the Treatment of dtCCHSuspendedNCT06124534Not applicable1 country
- An Open Internet-based Survey and Natural Language Processing Project Analysing Written Monologues by Headache PatientsCompletedNCT051538761 country
- Risk Taking and Decision-making in Cluster Headache PatientsCompletedNCT064108721 country
- GON-injection for a Sooner and Better Treatment of Cluster HeadacheCompletedNCT04014634Phase 41 country
- mBrain-21 : a Three-month Study on Context-awareness, Physiological Monitoring, and Machine Learning in Migraine and Cluster HeadacheCompletedNCT04983186Not applicable1 country
- Efficacy of Erenumab in Chronic Cluster HeadacheCompletedNCT04970355Phase 21 country
- Psilocybin for the Treatment of Cluster HeadacheCompletedNCT02981173Phase 11 country