ClinicalTrials.gg
RecruitingNCT02139163CAPNETZUpdated May 5, 2026

Epidemiological Study on Community Acquired Pneumonia

An observational study in Community Acquired Pneumonia, sponsored by Capnetz Stiftung. Recruiting at 1 site in Germany. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-05-05.

Sponsored by Capnetz Stiftung · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
20,000
Ages
18 Years and older
Sex
All
01

Study summary

The main objective of this study is to investigate prevalence and risk factors for community-acquired pneumonia (CAP) and its interaction with comorbidities in an unselected group of adult patients receiving outpatient and inpatient care. In addition, information on HIV as a risk factor for CAP and on CAP in immunocompromised patients is collected.

Read the detailed description

The CAPNETZ study is a prospective, multicenter observational study investigating community-acquired pneumonia (CAP). Patients are recruited from outpatient and inpatient settings at hospitals and from primary care physicians (primarily specialists) and are followed for a period of six months. All CAP patients who meet the inclusion and exclusion criteria, consent to participate, and in whom the presence of a newly developed, community-acquired pneumonia can be verified are invited to participate. The baseline examination includes a detailed medical history, medication history, and a physical examination to record clinical and vital signs. In addition, the results of routine clinical imaging are documented, and biosamples (blood, urine, and respiratory specimens) are collected for clinical chemistry and microbiological analysis. Further in-person visits to document the course of the disease and treatment, including the collection of additional blood samples, take place 3 and 7 days after study enrollment. Twenty-eight days after enrollment, the patient's health status, treatment course, and complications are assessed by telephone. Finally, after 180 days, a telephone survey is conducted to determine the patient's whereabouts and survival status. Apart from the collection of biomaterials, no interventions are required or planned; physicians treat their patients as they normally would.

02

Conditions studied

  • Community Acquired Pneumonia

Keywords

  • Community acquired pneumonia
  • CAP
  • CAPNETZ
  • age ≥18
  • infiltrate on chest X-ray
  • cough or production of purulent sputum
  • pathologic lung auscultation
  • fever
  • adults
03

In context

Community-Acquired Pneumonia

324 studies on the registry are indexed under Community-Acquired Pneumonia; 77 are open to participants now.

This study's planned enrollment of 20,000 is above the median of 650 across 111 observational studies indexed under Community-Acquired Pneumonia.

Browse Community-Acquired Pneumonia studies →

Lead sponsor

This is the only study on the registry with Capnetz Stiftung as lead sponsor.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

patients with pneumonia

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • age ≥ 18
  • infiltrate on chest X-ray
  • further Inclusion criteria (at least one must apply): cough or purulent sputum or pathologic lung auscultation (crackles) or fever

Exclusion criteria

Exclusion Criteria:

  • Hospitalization lasting longer than 48 hours prior to the diagnosis of the current pneumonia
  • Newly diagnosed, active pulmonary tuberculosis within the last 2 months
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
20,000 participants (estimated)
Target follow-up
6 Months
Patient registry
Yes
Biospecimen retention
Samples with dna

Groups and cohorts

  • patients with pneumonia
  • patients with CAP and HIV
  • immunosuppressed patients with CAP
06

What researchers measure

Primary outcomes

  1. diagnosis

    Assessment of diagnosis: Patients will be asked for example, about their diagnosis, comorbidities, specific risk factors and pneumonia symptoms.

    Time frame: 2 weeks

  2. therapy

    Assessment of therapy: Patients will be asked about their therapy due to pneumonia symptoms, previous therapy, medication History etc.

    Time frame: 2 weeks

  3. hospitalization

    Assessment of hospitalization: Patients will be asked about hospitalization, date, time and duration of hospitalization due to pneumonia symptoms.

    Time frame: 2 weeks

07

Study locations

1 of 1 sites recruiting
08

References and documents

Publications

  • Welte T, Suttorp N, Marre R. CAPNETZ-community-acquired pneumonia competence network. Infection. 2004 Aug;32(4):234-8. doi: 10.1007/s15010-004-3107-z. No abstract available. PubMed 15293080 ↗
  • Welte T, Marre R, Suttorp N. [CAPNet--network of competence for community acquired pneumonia: structures and aims]. Pneumologie. 2003 Jan;57(1):34-41. doi: 10.1055/s-2003-36635. German. PubMed 12528066 ↗
  • Weckler BC, Wu Q, Bertrams W, Kutzinski M, Reiter R, Khan SA, Ahnert P, Suttorp N, Witzenrath M, Wildberg C, Pletz MW, Rupp J, Zissler UM, Greulich T, Brenner T, Alter P, Rohde G, Vogelmeier CF, Mayr A, Schmeck B. Association Between Admission Eosinophil Count and Hospital Resource Use in Community-Acquired Pneumonia: A Prospective Multicenter Study. Chest. 2026 Mar 31:S0012-3692(26)00427-7. doi: 10.1016/j.chest.2026.03.018. Online ahead of print. PubMed 41933608 ↗
  • Mendez R, Gonzalez-Jimenez P, Latorre A, Piqueras M, Mengot N, Hervas D, Knox D, Carr J, Barten-Neiner G, Rohde G, Pletz MW, Rupp J, Witzenrath M, Dean NC, Menendez R. The Long-term Pneumonia Mortality Index: an international multicenter derivation and validation study for patients with community-acquired pneumonia. Am J Respir Crit Care Med. 2026 Jun 1;212(6):1305-1314. doi: 10.1093/ajrccm/aamag060. PubMed 41738235 ↗
  • Millet Pascual-Leone B, Fiocca Vernengo F, Hillus D, Wernicke C, Krishnamoorthy G, Rupp J, Rohde G, Pletz MW, Witzenrath M; CAPNETZ-study group; Suttorp N, Sander LE, Vestergaard Jensen A, Opitz B, Thibeault C. Community-acquired pneumonia in diabetic patients is characterised by a distinct pathogen spectrum and enhanced inflammation: results from CAPNETZ, a prospective observational cohort study. Infection. 2026 Feb;54(1):275-285. doi: 10.1007/s15010-025-02659-w. Epub 2025 Oct 12. PubMed 41077620 ↗
  • Pott H, Gaffron S, Martin R, Maier D, Kutzinski M, Weckler B, Bertrams W, Jung AL, Laakmann K, Heider D, Vogelmeier CF, Rohde G; CAPNETZ Study Group; Schmeck B. Self-organising map clustering identifies high-risk clusters of post-acute mortality in a prospective multicentre study of community-acquired pneumonia. ERJ Open Res. 2026 Jan 19;12(1):00374-2025. doi: 10.1183/23120541.00374-2025. eCollection 2026 Jan. PubMed 41561102 ↗
  • Waldeck F, Lemmel S, Panning M, Kading N, Essig A, Rohde G, Pletz MW, Witzenrath M, Boutin S, Rupp J; Members of the CAPNETZ study group. Comparing viral, bacterial, and coinfections in community-acquired pneumonia, a retrospective cohort study. Int J Infect Dis. 2025 May;154:107841. doi: 10.1016/j.ijid.2025.107841. Epub 2025 Feb 21. PubMed 39988242 ↗
  • Rischke S, Gurke R, Zielbauer AS, Ziegler N, Hahnefeld L, Kohm M, Kannt A, Vehreschild MJ, Geisslinger G, Rohde G, Bellinghausen C, Behrens F, Study Group C. Proteomic, metabolomic and lipidomic profiles in community acquired pneumonia for differentiating viral and bacterial infections. Sci Rep. 2025 Jan 14;15(1):1922. doi: 10.1038/s41598-025-85229-2. PubMed 39809876 ↗
  • Dahne T, Bauer W, Essig A, Schaaf B, Barten-Neiner G, Spinner CD, Pletz MW, Rohde G, Rupp J, Witzenrath M, Panning M; Members of the CAPNETZ study group. Resurgence of common respiratory viruses in patients with community-acquired pneumonia (CAP)-A prospective multicenter study. J Clin Virol. 2024 Aug;173:105694. doi: 10.1016/j.jcv.2024.105694. Epub 2024 May 22. PubMed 38781632 ↗
  • Schleenvoigt BT, Ankert J, Barten-Neiner G, Voit F, Suttorp N, Boesecke C, Hoffmann C, Stolz D, Pletz MW, Rohde G, Witzenrath M, Panning M, Essig A, Rupp J, Degen O, Stephan C; CAPNETZ Study Group. Pathogen spectrum of community acquired pneumonia in people living with HIV (PLWH) in the German CAPNETZ-Cohort. Infection. 2024 Feb;52(1):129-137. doi: 10.1007/s15010-023-02070-3. Epub 2023 Jul 9. PubMed 37423969 ↗
  • Bahrs C, Kesselmeier M, Kolditz M, Ewig S, Rohde G, Barten-Neiner G, Rupp J, Witzenrath M, Welte T, Pletz MW; CAPNETZ Study Group. A longitudinal analysis of pneumococcal vaccine serotypes in pneumonia patients in Germany. Eur Respir J. 2022 Feb 3;59(2):2102432. doi: 10.1183/13993003.02432-2021. Print 2022 Feb. PubMed 34824055 ↗
  • Ewig S, Kolditz M, Pletz M, Altiner A, Albrich W, Dromann D, Flick H, Gatermann S, Kruger S, Nehls W, Panning M, Rademacher J, Rohde G, Rupp J, Schaaf B, Heppner HJ, Krause R, Ott S, Welte T, Witzenrath M. [Management of Adult Community-Acquired Pneumonia and Prevention - Update 2021 - Guideline of the German Respiratory Society (DGP), the Paul-Ehrlich-Society for Chemotherapy (PEG), the German Society for Infectious Diseases (DGI), the German Society of Medical Intensive Care and Emergency Medicine (DGIIN), the German Viological Society (DGV), the Competence Network CAPNETZ, the German College of General Practitioneers and Family Physicians (DEGAM), the German Society for Geriatric Medicine (DGG), the German Palliative Society (DGP), the Austrian Society of Pneumology Society (OGP), the Austrian Society for Infectious and Tropical Diseases (OGIT), the Swiss Respiratory Society (SGP) and the Swiss Society for Infectious Diseases Society (SSI)]. Pneumologie. 2021 Sep;75(9):665-729. doi: 10.1055/a-1497-0693. Epub 2021 Jul 1. German. PubMed 34198346 ↗
  • Jensen AV, Baunbaek Egelund G, Bang Andersen S, Petersen PT, Benfield T, Witzenrath M, Rohde G, Ravn P, Faurholt-Jepsen D; Members of the CAPNETZ study group except the authors:. The Glycemic Gap and 90-Day Mortality in Community-acquired Pneumonia. A Prospective Cohort Study. Ann Am Thorac Soc. 2019 Dec;16(12):1518-1526. doi: 10.1513/AnnalsATS.201901-007OC. PubMed 31437014 ↗
  • Kolditz M, Scherag A, Rohde G, Ewig S, Welte T, Pletz M; CAPNETZ Study Group. Comparison of the qSOFA and CRB-65 for risk prediction in patients with community-acquired pneumonia. Intensive Care Med. 2016 Dec;42(12):2108-2110. doi: 10.1007/s00134-016-4517-y. Epub 2016 Sep 19. No abstract available. PubMed 27647332 ↗
  • Kolditz M, Ewig S, Schutte H, Suttorp N, Welte T, Rohde G; CAPNETZ study group. Assessment of oxygenation and comorbidities improves outcome prediction in patients with community-acquired pneumonia with a low CRB-65 score. J Intern Med. 2015 Aug;278(2):193-202. doi: 10.1111/joim.12349. Epub 2015 Feb 13. PubMed 25597400 ↗
  • Glockner V, Pletz MW, Rohde G, Rupp J, Witzenrath M, Barten-Neiner G, Kolditz M; CAPNETZ Study Group. Early post-discharge mortality in CAP: frequency, risk factors and a prediction tool. Eur J Clin Microbiol Infect Dis. 2022 Apr;41(4):621-630. doi: 10.1007/s10096-022-04416-5. Epub 2022 Feb 8. PubMed 35137301 ↗

Study documents

PDFs hosted by the registry, ClinicalTrials.gov.

Individual participant data

Plan to share: Yes — All individual non-personal data and biomaterials collected as part of the study are available for use. This requires a formal request that describes a specific research project and specifies the data needed. Applications have to be submitted on https://capnetz.de/en/project-application/ . Upon approval by the Executive Board, the relevant data and biomaterials will be provided.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 5, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT02139163
Lead sponsor
Capnetz Stiftung
Collaborators
Deutsches Zentrum für Lungenforschung e. V.
Responsible party
Sponsor
First posted
May 15, 2014
Start date
Oct 2002
Primary completion
Dec 2027 (estimated)
Completion
Jun 2028 (estimated)
Last update
May 5, 2026

Study contacts

Frank Eberhardt
Contact
office@capnetz.de
+49-511-532-5927
Waldemar Kröner
Contact
office@capnetz.de
+49-511-532-4447
Gernot G. U. Rohde, Prof. Dr.
study chair · University Hospital Giessen and Marburg
Mathias W. R. Pletz, Prof. Dr.
study chair · University Hospital Jena
Jan Rupp, Prof. Dr.
study chair · University Hospital Schleswig-Holstein
Martin Witzenrath, Prof. Dr.
study chair · Charité - Universitaetsmedizin Berlin
Jessica Rademacher, Prof. Dr.
study chair · Medical School Hannover
Grit Barten-Neiner
study chair · Capnetz Stiftung

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Interested in this study?

Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.

Contact study team

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion