Drug class
Beta-Lactamase Inhibitors clinical trials
A class of medicines: the studies that test any of its 23 members, each study once. Members are as MeSH files each medicine’s actions, and as the NCI Thesaurus classes newer ones.
Keep track of what changes. Save the beta-lactamase inhibitors studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesMedicines in this class
Studies that test each. A study of two counts under both, and once above.
- Piperacillin, Tazobactam Drug Combination
- 48
- Ceftolozane, tazobactam drug combination
- 19
- Avibactam, ceftazidime drug combination
- 16
- QPX7728
- 2
- L 084
- 1
- Vaborbactam
- 1
- Ticarcillin-clavulanic acid
- 1
Studies by the year they started
291 studies that test it; most in 2019 (19); 2 more planned to start later
| Year | Studies |
|---|---|
| 1997 | 1 |
| 1998 | 1 |
| 1999 | 1 |
| 2000 | 2 |
| 2001 | 1 |
| 2002 | 3 |
| 2003 | 5 |
| 2004 | 4 |
| 2005 | 4 |
| 2006 | 9 |
| 2007 | 2 |
| 2008 | 3 |
| 2009 | 8 |
| 2010 | 11 |
| 2011 | 10 |
| 2012 | 15 |
| 2013 | 18 |
| 2014 | 15 |
| 2015 | 12 |
| 2016 | 17 |
| 2017 | 15 |
| 2018 | 13 |
| 2019 | 19 |
| 2020 | 18 |
| 2021 | 10 |
| 2022 | 12 |
| 2023 | 15 |
| 2024 | 13 |
| 2025 | 17 |
| 2026 | 17 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 116 · Other 178
Pfizer (19) · Merck Sharp & Dohme LLC (13) · Spero Therapeutics (11) · Wyeth is now a wholly owned subsidiary of Pfizer (9) · Wockhardt (6) · Qilu Pharmaceutical Co., Ltd. (6) · Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (6) · Qpex Biopharma, Inc. (5)
Studies
Open first, then newest update. How each study uses a medicine is read from its arms, and is right about nine times in ten.
Testing one of them · 294
- Comparative Effectiveness of Available Treatments for Sinus and Ear Infections in Children (Acute Otitis Media)RecruitingPhase 4Nader ShaikhNCT07730814Written as Amoxicillin-Clavulanate
- Comparative Effectiveness of Available Treatments for Sinus and Ear Infections in Children (Acute Sinusitis)RecruitingPhase 4Nader ShaikhNCT07732699Written as Amoxi Clavulanate
- Amoxicillin-clavulanate Versus Amoxicillin Versus Placebo in Acute Otitis Media in ChildrenNot yet recruitingPhase 4Kuopio University HospitalNCT07878910Written as Amoxicillin + Clavulanate
- The Vancomycin Piperacillin/Tazobactam (VPT) Patient Safety Trial (VPS)RecruitingPhase 4Bassett HealthcareNCT07556107Written as Piperacillin + Tazobactam
- Comparison of Topical Antibiotics Versus Systemic Antibiotics in Preventing Burn Wound Infection in Pediatric Burn PatientsNot yet recruitingNot applicableabdul mateenNCT07870239Written as Amoxicillin and clavulanate
- Piperacillin/Tazobactam Versus Ceftriaxone and Metronidazole for Children With Perforated AppendicitisNot yet recruitingPhase 3McMaster Children's HospitalNCT07869095Written as Piperacillin/Tazobactam
- A Study to Assess How Vaborem® is Taking up in the Body and Tolerated in Paediatric Patients With Gram Negative Infections, Including But Not Restricted to Complicated Urinary Tract InfectionsRecruitingPhase 2Menarini GroupNCT06828848Written as Meropenem plus vaborbactam
- A Study to Assess Sulbactam-durlobactam in Pediatric Patients With Acinetobacter Baumannii-calcoaceticus Complex InfectionRecruitingPhase 1Innoviva Specialty TherapeuticsNCT06801223Written as Sulbactam 25mg/kg -Durlobactam 25mg/kg (Every 6 hours)
- Patient Choice Between Antibiotics and Appendectomy in Uncomplicated Appendicitis (FRENCH 47 - ALACARTE)Not yet recruitingPhase 2Assistance Publique - Hôpitaux de ParisNCT07857252Written as amoxicillin-clavulanate
- Antibiotics After Incision and Drainage to Prevent Fistula Formation After First Episode of Perianal AbscessNot yet recruitingPhase 4University of Illinois at ChicagoNCT07704359Written as Amoxicillin + Clavulanate
- Ceftolozane/Tazobactam Versus Meropenem for Febrile Neutropenia on Patients Colonized With or at Risk for Infection With Extended Spectrum Beta Lactamase - Producing PathogensRecruitingPhase 4Beneficência Portuguesa de São PauloNCT06342115Written as Ceftolozane-Tazobactam
- Fast Track Therapeutic Model in Acute Complicated Appendicitis in PediatricsRecruitingPhase 4Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant PauNCT05761080Written as Oral amoxicillin-clavulanic acid (40mg/kg in 3 times/day; maximum dose 3g/day)
- Targeted Versus Standard Peri-operative Antibiotic Prophylaxis in Patients Colonized With Carbapenemase Producing Enterobacterales Undergoing Liver TransplantationNot yet recruitingPhase 3IRCCS Azienda Ospedaliero-Universitaria di BolognaNCT07759453Written as Ceftazidime - Avibactam ( CAZ-AVI)
- Safety and PK of Ceftibuten-ledaborbactam Etzadroxil Fixed-dose CombinationRecruitingPhase 1Basilea PharmaceuticaNCT06733675Written as Ledaborbactam etzadroxil
- Postoperative Anti-infective Strategy Following Pancreaticoduodenectomy in Patients With Preoperative Biliary StentNot yet recruitingPhase 3University Hospital, RouenNCT06123169Written as Antibioprophylaxis (Piperacillin-tazobactam)
- Prophylactic Antibiotics in Preventing Surgical Site Infection After Hepatobiliary Surgery in High-Resistant SettingsRecruitingNot applicableThe Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical SchoolNCT07620223Written as Piperacillin-tazobactam
- Efficacy of Non Operative Treatment With Amoxicillin/Clavulanic Acid Versus Surgical Treatment in Acute Uncomplicated Appendicitis in ChildrenNot yet recruitingPhase 3University Hospital, ToulouseNCT07587450Written as Amoxi Clavulanate
- Finnish Children´s Protracted CoughRecruitingPhase 3Tampere University HospitalNCT07582549Written as Amoxicillin-clavulanic acid oral suspension
- Prospective Clinical Investigation on Infection as a Cause of Chronic Subdural Hematoma.RecruitingPhase 2/3University of RostockNCT07556991Written as Amoxicillin + clavulanic acid
- Aminoglycosides in Early SepsisRecruitingPhase 4University Hospital, AkershusNCT06712641Written as Piperacillin-tazobactam
See all 294 studies that test one of the beta-lactamase inhibitors →