An interventional study of Capillary CRP in Fever, sponsored by Centre Hospitalier Universitaire de Nīmes. Recruiting at 37 sites in France. Open to participants aged 3 Months to 15 Years. Per ClinicalTrials.gov, last updated 2026-06-23.
Sponsored by Centre Hospitalier Universitaire de Nīmes · Not applicable, Interventional, and Other
Fever is the leading reason for outpatient consultations among children aged 2 to 9 years. The main concern in fever is severe bacterial infection, particularly for younger children. History and clinical examination do not always differentiate viral infections from bacterial infection. In 20% of febrile children, no infectious focus is found after examination and additional tests are necessary. The first one is measuring C-reactive protein (CRP). The results are obtained in several hours on an outpatient basis, causing long delays before starting treatment and often requiring telephone calls or further consultations. Emergency room use is constantly increasing, generating growing tensions within healthcare facilities, yet a large number of visits are avoidable. Among children visiting the pediatric emergency room, parents reported being referred by their primary care physician in approximately 20% of cases for children aged 1 to 5 years and in 30% of cases for children under one year old. The use of capillary medical device to measure CRP in primary care could reduce this referral rate and help relieve overcrowding in emergency rooms, as well as unscheduled consultation centers and medical analysis laboratories. This would result in a streamlined care pathway, saving time for both physicians and patients, as well as reducing the cost of care for the healthcare system.
438 studies on the registry are indexed under Fever; 55 are open to participants now.
This study's planned enrollment of 420 is above the median of 123 across 271 interventional studies indexed under Fever.
Browse Fever studies →Centre Hospitalier Universitaire de Nīmes is the lead sponsor of 595 studies on the registry; 90 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Children consulting primary health institutes with fever (temperature ≥ 38°C) requiring CRP testing:
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.
Read whether the line is about a condition or about medicines, and which medicines and doses it means.
A condition in which the immune system attacks the body’s own tissues, such as rheumatoid arthritis, lupus, psoriasis, type 1 diabetes or inflammatory bowel disease.
Immunotherapy studies often leave out active autoimmune disease, and some name exceptions, such as thyroid disease on replacement hormone. Check the exceptions this study lists.
Immunosuppression
A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.
Read whether the line is about a condition or about medicines, and which medicines and doses it means.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Autoimmune disease
A condition in which the immune system attacks the body’s own tissues, such as rheumatoid arthritis, lupus, psoriasis, type 1 diabetes or inflammatory bowel disease.
Immunotherapy studies often leave out active autoimmune disease, and some name exceptions, such as thyroid disease on replacement hormone. Check the exceptions this study lists.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Other: Capillary CRP
Prior to Capillary CRP condition
CRP measured semi-quantitatively using ACTIM-CRP device
Referral rates to any facility equipped for emergency laboratory testing between conditions
Referral: Yes/No as reported by the physician
Time frame: Day 1
Referral rates to any facility equipped for emergency laboratory testing between conditions
Referral: Yes/No as reported by the parents
Time frame: Day 7
Referral rates to medical biology laboratories between conditions
Referral: Yes/No as reported by the physician
Time frame: Day 1
Referral rates to medical biology laboratories between conditions
Referral: Yes/No as reported by the parents
Time frame: Day 7
Referral rates to emergency departments between conditions
Referral: Yes/No as reported by the physician
Time frame: Day 1
Referral rates to emergency departments between conditions
Referral: Yes/No as reported by the parents
Time frame: Day 7
Number complementary tests between conditions
Total number of tests as reported by the physician
Time frame: Day 1
Number complementary tests between conditions
Total number of tests as reported by the parents
Time frame: Day 7
Type of complementary tests between conditions
Qualitative listing of all further tests classified as: biological (CBC, venous CRP, iono/creatininemia, liver function tests, ECBU, others) or imaging (chest X-ray, abdomino-pelvic ultrasound, urinary and renal ultrasound) as reported by the physician
Time frame: Day 1
Type of complementary tests between conditions
Qualitative listing of all further tests classified as: biological (CBC, venous CRP, iono/creatininemia, liver function tests, ECBU, others) or imaging (chest X-ray, abdomino-pelvic ultrasound, urinary and renal ultrasound) as reported by the parents
Time frame: Day 7
GP satisfaction on care organization
0-10 visual analog scale
Time frame: Day 7
The total duration of GP time between conditions
Minutes: measured as consultation time + examination time and time to inform the family
Time frame: Day 7
Parent satisfaction with the care pathway
0-10 numeric scale
Time frame: Day 7
Rate of antibiotic prescription between conditions
Antibiotic prescription: Yes/No as reported by the physician
Time frame: Day 1
Rate of antibiotic prescription between conditions
Antibiotic prescription: Yes/No as reported by the parents
Time frame: Day 7
Duration of fever episode between groups
Days counted upon reaching 24 hours without fever
Time frame: Day 7
Cost-consequences between groups
euros
Time frame: Day 7
Budget impact analysis
euros
Time frame: Day 7
Plan to share: Yes — All IPD that underlie results in a publication
Supporting information: Study protocol, Informed consent form, Analytic code
Time frame: Upon publication
Access criteria: The IPD will be made available to other researchers upon reasonable request to the corresponding author
Started Sep 2025 (actual). Primary completion is estimated for Jun 2027, 21 months after the start.
Of 66 non-industry interventional studies with no phase under Fever, half reached primary completion within 17 months of starting (the median), counting those still running; a quarter within 7 and three quarters within 30. This study's planned 21 months is above that.
Counting every sponsor, half of 74 studies reached it within 16 months; a quarter within 6 and three quarters within 30.
How these figures are worked out, and which studies are left out of them.
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