An interventional study of Paracetamol and Paracetamol+Cold Sponging in Fever, sponsored by Muhammad Aamir Latif. Not yet recruiting at 1 site in Pakistan. Open to participants aged 6 Months to 60 Months. Per ClinicalTrials.gov, last updated 2026-02-23.
Sponsored by Muhammad Aamir Latif · Not applicable, Interventional, and Treatment
This study aims to fill the gaps regarding the effectiveness of paracetamol alone with paracetamol combined with cold sponging in febrile children.
Given the conflicting findings in existing literature, the role of cold sponging in fever management remains uncertain. Some studies suggest a transient advantage in early temperature reduction, while others highlight limited long-term benefit and increased discomfort. Therefore, this study seeks to determine whether cold sponging offers meaningful additional benefit or merely adds distress without enhancing the efficacy of paracetamol. The findings would generate evidence-based guidance for using cold sponging in febrile children.
438 studies on the registry are indexed under Fever; 55 are open to participants now.
This study's planned enrollment of 210 is above the median of 123 across 271 interventional studies indexed under Fever.
Browse Fever studies →Muhammad Aamir Latif is the lead sponsor of 57 studies on the registry; 9 are open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
An allergy, or another reaction of the immune system, to a substance. “Hypersensitivity to the study drug” means a known allergic reaction to it — not every side effect a medicine can have.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Hypersensitivity
An allergy, or another reaction of the immune system, to a substance. “Hypersensitivity to the study drug” means a known allergic reaction to it — not every side effect a medicine can have.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Children will receive paracetamol alone, as a single dose of paracetamol syrup (15 mg/kg) orally.
Drug: Paracetamol
Children will receive paracetamol as a single dose of paracetamol syrup (15 mg/kg) orally, and cold sponging will be performed immediately following paracetamol administration for 15 minutes, using room-temperature water (approximately 25°C) to sponge the forehead, arms, and legs.
Combination Product: Paracetamol+Cold Sponging
Children will receive paracetamol alone, as a single dose of paracetamol syrup (15 mg/kg) orally.
Children will receive paracetamol as a single dose of paracetamol syrup (15 mg/kg) orally, and cold sponging will be performed immediately following paracetamol administration for 15 minutes, using room-temperature water (approximately 25°C) to sponge the forehead, arms, and legs.
Fever reduction
Achievement of a temperature \<38°C within 60 minutes will be considered as the reduction in fever and effectiveness of the treatment.
Time frame: 60 minutes
Change in heart rate
The change in the heart rate will be compared between the two groups.
Time frame: 60 minutes
Change in respiratory rate
The change in the respiratory rate will be compared between the two groups.
Time frame: 60 minutes
Plan to share: No — Data can be shared on a reasonable request.
No publications or documents are linked to this record.
Start is estimated for Mar 2026; primary completion for Aug 2026, 5 months later.
Of 66 non-industry interventional studies with no phase under Fever, half reached primary completion within 17 months of starting (the median), counting those still running; a quarter within 7 and three quarters within 30. This study's planned 5 months is below that.
Counting every sponsor, half of 74 studies reached it within 16 months; a quarter within 6 and three quarters within 30.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Feb 2026. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Acetaminophen
Muhammad Aamir Latif