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RecruitingNCT01617382HIPECUpdated Sep 3, 2026

Register With Patients in Which Hyperthermic Intra-Peritoneal Chemotherapy (HIPEC) Was Performed

An observational study in Peritoneal Carcinomatosis, Pseudomyxoma Peritonei and Peritoneal Mesothelioma, sponsored by Universitaire Ziekenhuizen KU Leuven. Recruiting at 1 site in Belgium. Per ClinicalTrials.gov, last updated 2026-09-03.

Sponsored by Universitaire Ziekenhuizen KU Leuven · Observational

From the registry’s dates

  • Started May 2012; still recruiting 14 years 6 months later.
Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
125
Sex
All
01

Study summary

The purpose of this study is to register the follow-up data of patients who, because of a peritoneal surface malignancy, will undergo cytoreductive surgery and HIPEC.

Read the detailed description

To register the follow-up data of patients who, because of a peritoneal surface malignancy, will undergo cytoreductive surgery and HIPEC. In this surgical intervention, the abdominal cavity is macroscopically cleared of tumor, by removing all visible tumor nodules, and is subsequently rinsed with hyperthermic (heated) chemotherapy, aiming to destroy all residual invisible tumor cells that might have stayed behind after the debulking.

The eventual aim of this procedure is to improve the prognosis/survival of patients with malignancies localized on the peritoneal surface.

02

Conditions studied

  • Peritoneal Carcinomatosis
  • Pseudomyxoma Peritonei
  • Peritoneal Mesothelioma

Keywords

  • HIPEC
  • Hyperthermic (heated) chemotherapy after debulking
03

In context

Peritoneal Neoplasms

249 studies on the registry are indexed under Peritoneal Neoplasms; 55 are open to participants now.

This study's planned enrollment of 125 is above the median of 100 across 43 observational studies indexed under Peritoneal Neoplasms.

Browse Peritoneal Neoplasms studies →

Lead sponsor

Universitaire Ziekenhuizen KU Leuven is the lead sponsor of 963 studies on the registry; 267 are open to participants now.

Of its 5 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients with peritoneal carcinomatosis of colorectal origin, patients with pseudomyxoma peritonei (type DPAM or PMCA) and patients with peritoneal mesothelioma who are planned to undergo cytoreductive surgery and HIPEC because of a peritoneal surface malignancy.

Eligibility criteria

Inclusion Criteria:

  • Patients with peritoneal carcinomatosis of colorectal origin, patients with pseudomyxoma peritonei (type DPAM or PMCA) and patients with peritoneal mesothelioma who are planned to undergo cytoreductive surgery and HIPEC because of a peritoneal surface
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Cancer (malignancy)

Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.

Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.

05

Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
125 participants (estimated)

Groups and cohorts

  • Registry

    Patients with peritoneal carcinomatosis of colorectal origin, patients with pseudomyxoma peritonei (type DPAM or PMCA) and patients with peritoneal mesothelioma who are planned to undergo cytoreductive surgery and HIPEC because of a peritoneal surface malignancy

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What researchers measure

Primary outcomes

  1. To improve the prognosis/survival of patients with malignancies localized on the peritoneal surface.

    Time frame: Follow-up over a time period of at least 5 years

07

Study locations

1 of 1 sites recruiting
  • University Clinics Gasthuisberg
    Leuven, Flemish Brabant 3000, Belgium
    Recruiting
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Started May 2012 (actual). Primary completion is estimated for Dec 2028, 199 months after the start.

Of 23 observational studies under Peritoneal Neoplasms, half reached primary completion within 71 months of starting (the median), counting those still running; a quarter within 23. This study's planned 199 months is above that.

How these figures are worked out, and which studies are left out of them.

Registered
Jun 8, 2012
First posted
Jun 12, 2012
StartActual
May 2012
Primary completionEst.
Dec 2028
CompletionEst.
Dec 2028
Last update
Sep 3, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Sep 3, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT01617382
Responsible party
Sponsor
First posted
Jun 12, 2012
Start date
May 2012
Primary completion
Dec 2028 (estimated)
Completion
Dec 2028 (estimated)
Last update
Sep 3, 2026

Study contacts

Isabelle B Terrasson
Contact
isabelle.terrasson@uzleuven.be
+32 16 340837
André JL D'Hoore, PhD
principal investigator · University Clinics Gasthuisberg Department of Abdominal Surgery

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

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