An observational study in Postoperative Delirium, Emergency Surgery, sponsored by Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-11-10.
Sponsored by Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization · Observational
This prospective observational study aims to evaluate whether the modified Surgical APGAR Score (mSAS), calculated at the end of surgery from the lowest intraoperative heart rate, lowest mean arterial pressure, estimated blood loss, and operation time, can predict postoperative delirium in adult patients undergoing emergency surgery. Postoperative delirium is assessed with the CAM-ICU-7 on postoperative days 1, 2, 3, and 5. As a secondary aim, the relationship between postoperative delirium and major complications and mortality within 30 days after surgery is investigated.
Patients aged 18 years or older undergoing emergency surgery in any surgical specialty at Istanbul Prof. Dr. Cemil Tascioglu City Hospital were enrolled after written informed consent. Preoperative data (age, sex, ASA physical status, diagnosis, planned operation, surgical specialty, pre-induction Glasgow Coma Scale, and anesthesia technique) were recorded. Intraoperative heart rate and mean arterial pressure were obtained from anesthesia monitor trend data (heart rate at 1-minute intervals; mean arterial pressure at 1-minute intervals with invasive monitoring and 5-minute intervals with non-invasive monitoring). Estimated blood loss was calculated from suction canister contents, irrigation fluids, and blood-soaked gauze/sponges. Operation time was defined as the interval from induction of anesthesia to the end of surgery. The mSAS was calculated for each patient at the end of surgery.
Postoperative delirium and its severity were assessed by the investigator using the CAM-ICU-7 on postoperative days 1, 2, 3, and 5 in both ICU and ward patients, supported by observations of caregivers. The SOFA score was calculated from the worst values in the first 24 postoperative hours. Length of hospital stay, ICU admission and length of ICU stay, and 24th-hour Glasgow Coma Scale were recorded. Patients were followed for 30 days for major complications and mortality using hospital records, clinical notes, and telephone interviews after discharge.
751 studies on the registry are indexed under Emergence Delirium; 262 are open to participants now.
This study's enrollment of 424 is above the median of 162 across 279 observational studies indexed under Emergence Delirium.
Browse Emergence Delirium studies →Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization is the lead sponsor of 87 studies on the registry; 15 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Adult patients undergoing emergency surgery in any surgical specialty at a tertiary city hospital in Istanbul, Türkiye.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Adults aged 18 years or older undergoing emergency surgery in any surgical specialty, in whom the modified Surgical APGAR Score was calculated at the end of surgery.
Other: Modified Surgical APGAR Score assessment
Calculation of the modified Surgical APGAR Score at the end of surgery using the lowest intraoperative heart rate, lowest mean arterial pressure, estimated blood loss, and operation time. No intervention is applied to the patient.
Incidence of postoperative delirium
Presence of postoperative delirium assessed with the Confusion Assessment Method for the Intensive Care Unit-7 (CAM-ICU-7), analyzed according to modified Surgical APGAR Score risk group.
Time frame: Postoperative days 1, 2, 3, and 5
Severity of postoperative delirium
CAM-ICU-7 total score (0-7); higher scores indicate more severe delirium.
Time frame: Postoperative days 1, 2, 3, and 5
Incidence of major postoperative complications
Includes ICU admission, unplanned intubation, mechanical ventilation within 48 hours, unplanned reoperation, blood transfusion, surgical site infection, new-onset arrhythmia, myocardial infarction, pneumonia, sepsis/septic shock, bacteremia, acute kidney injury, pulmonary embolism, deep vein thrombosis, postoperative inotrope/vasopressor requirement, and cardiac arrest requiring CPR.
Time frame: Within 30 days after surgery
All-cause mortality
Death from any cause.
Time frame: Within 30 days after surgery
Length of hospital stay
Number of postoperative days in hospital.
Time frame: Within 30 days after surgery
Length of ICU stay
Number of days in the intensive care unit.
Time frame: Up to 30 days after surgery
Duration of mechanical ventilation
Number of days on mechanical ventilation.
Time frame: Up to 30 days after surgery
SOFA score
Sequential Organ Failure Assessment score calculated from the worst values in the first 24 postoperative hours.
Time frame: First 24 hours after surgery
Plan to share: No — Individual participant data will not be shared due to institutional data protection regulations.
No publications or documents are linked to this record.
Ran from May 2025 to primary completion in May 2026, 11 months.
Of 181 non-industry observational studies under Emergence Delirium, half reached primary completion within 21 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 43. This study's 11 months is below that.
Counting every sponsor, half of 181 studies reached it within 21 months; a quarter within 10 and three quarters within 43.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Nov 2026. You cannot join it, but the record below documents what was studied.
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Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization