A Phase 3 interventional study of Sevoflurane and Isoflurane in Delirium on Emergence, sponsored by Mayo Clinic. Recruiting at 1 site in United States. Open to participants aged 2 Years to 7 Years. Per ClinicalTrials.gov, last updated 2025-12-16.
Sponsored by Mayo Clinic · Phase 3, Interventional, and Treatment
The purpose of this study is to measure the incidences of pediatric emergence delirium between the group receiving Isoflurane and the group receiving Sevoflurane plus intravenous push dexmedetomidine.
763 studies on the registry are indexed under Emergence Delirium; 241 are open to participants now.
This study's planned enrollment of 400 is above the median of 120 across 475 interventional studies indexed under Emergence Delirium.
Browse Emergence Delirium studies →Mayo Clinic is the lead sponsor of 3,218 studies on the registry; 670 are open to participants now.
Of its 445 completed or terminated interventional studies of FDA-regulated products, 313 (70%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Drug: Isoflurane
Drug: Sevoflurane
Subjects will receive standard of care anesthesia Sevoflurane, with intravenous push Dexmedetomidine
Subjects will receive standard of care anesthesia Isoflurane
Number of subjects with emergence delirium
Total number of subjects with a Pediatric Anesthesia Emergence Delirium (PAED) score of \> 10. The PAED scale consists of 5 criteria that are scored using a 5-point scale. The scores of each criterion are added to make a total score. The maximum achievable total score is 20.
Time frame: Within 1 hour after dropped off by anesthesiology team
Post Anesthesia Care Unit (PACU) length of stay
Number of hours spent in PACU during recovery
Time frame: Post-procedural (0-4 hours after anesthesiology drop off)
Plan to share: No
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