An interventional study of Open Nephrectomy and Laparoscopic Nephrectomy in Postoperative Delirium (POD) After Nephrectomy, sponsored by Alexandria University. Completed at 1 site in Egypt. Open to participants aged 65 Years to 85 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-23.
Sponsored by Alexandria University · Not applicable, Interventional, and Supportive care
A prospective comparative clinical trial of postoperative delirium incidence in open versus laparoscopic nephrectomy
788 studies on the registry are indexed under Emergence Delirium; 250 are open to participants now.
This study's enrollment of 134 is above the median of 120 across 491 interventional studies indexed under Emergence Delirium.
Browse Emergence Delirium studies →Alexandria University is the lead sponsor of 586 studies on the registry; 128 are open to participants now.
Of its 13 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
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- Patients scheduled to undergo elective nephrectomy for benign or malignant renal conditions.
American Society of Anesthesiologists (ASA) physical status classification I, II, or III.
New York Heart Association (NYHA) functional classification class I or II.
Exclusion Criteria:
Documented history of dementia, neurological diseases, psychiatric illness, or active drug/psychotropic substance abuse prior to admission.
Preoperative hepatic encephalopathy grade III or IV.
Severe visual or hearing impairments that preclude effective patient communication.
Emergency nephrectomy procedures.
Inability or refusal to provide written informed consent.
Patients undergo traditional open elective nephrectomy under standard general anesthesia. Postoperative analgesia includes regular IV ketorolac and morphine patient-controlled analgesia (PCA) for 48 hours
Procedure: Open Nephrectomy
Patients undergo laparoscopic elective nephrectomy under standard general anesthesia. Postoperative analgesia follows the identical standardized protocol (IV ketorolac + morphine PCA).
Procedure: Laparoscopic Nephrectomy
Open nephrectomy
Laparoscopic Nephrectomy
Incidence of Postoperative Delirium
The presence or absence of delirium will be assessed using the Confusion Assessment Method (CAM). For patients who screen positive via CAM, delirium severity will be graded using the Delirium Index (DI). The DI scores 7 domains from 0 (absent) to 3 (severe), with a total score range of 0 to 21 (higher scores indicate worse severity.
Time frame: Once daily on Postoperative Days (POD) 1, 2, and 3.
Postoperative Pain Intensity at Rest and During Movement
Evaluated using the Visual Analog Scale (VAS), ranging from 0 cm (no pain) to 10 cm (worst possible pain
Time frame: Postoperative Days (POD) 1, 2, and 3.
Cumulative Postoperative Analgesic Consumption
Total intravenous morphine consumption (mg) via the Patient-Controlled Analgesia (PCA) device and total rescue IV morphine boluses (0.05 mg/kg) administered for breakthrough pain (VAS \> 4).
Time frame: Postoperative Days (POD) 1, 2, and 3.
Postoperative Functional Recovery Milestones
Time to first time sitting out of bed (hours), time to first ward ambulation (hours), time to first passage of flatus (hours), and overall length of hospital stay (days).
Time frame: From end of surgery up to hospital discharge (monitored daily, up to an estimated 14 days).
Intraoperative Hemodynamic and Anesthetic Depth Parameters
Mean Arterial Pressure (MAP in mmHg), Heart Rate (HR in bpm), Bispectral Index (BIS value), Oxygen Saturation (SpO2 percentage), and Arterial Blood Gas measurements (pH, PaO2 in mmHg, PaCO2 in mmHg).
Time frame: Baseline (Pre-induction, T1), 45 minutes intraoperatively (T2), 90 minutes intraoperatively (T3), and 10 minutes before the end of surgery (T4).
Plan to share: Undecided
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in May 2026. You cannot join it, but the record below documents what was studied.
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