A Phase 4 interventional study of propofol 1mg/kg and Dexmedetomidine in Emergence Delirium, Anesthesia, sponsored by Pakistan Institute of Medical Sciences. Recruiting at 1 site in Pakistan. Open to participants aged 2 Years to 12 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-02.
Sponsored by Pakistan Institute of Medical Sciences · Phase 4, Interventional, and Prevention
This is a clinical study for comparing the efficacy of two drugs i.e propofol and dexmedetomidine in prevention of a group of post operative abnormal behaviours that can occur after sevoflurane anesthesia in children and we will measure this by a special scale which is used to evaluate these behavioural changes.
A randomized clinical trial in which we will compare a single dose propofol with a single dose of dexmedetomodine given at the end of surgery after sevoflurane _based anesthesia to prevent post operative emergence agitation which is a group of behaviours consisting of confusion , disorientation,hyperactivity and even physical harm to themselves and others. this behavioural response is assessed by a score which is called peadriatric anesthesia emergence delerium scale (PEAD) which consist of 5-itms and 5-point scale ,ranging from not at all to extremely.the total score range from 0 to 20,with higher scores indicating more svere emergence agitation . In this study , the PEAD score will be recorded at 0,5,10,15,and 30 minutes after the child reach the recovery room ,and score greater than 10 at any of these readings will be taken as emergence agitation or delerium.
751 studies on the registry are indexed under Emergence Delirium; 262 are open to participants now.
This study's planned enrollment of 114 is close to the median of 120 across 464 interventional studies indexed under Emergence Delirium.
Browse Emergence Delirium studies →Pakistan Institute of Medical Sciences is the lead sponsor of 55 studies on the registry; 25 are open to participants now.
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1- age 2-12 years 2-elective inguinal hernia repair under general anesthesia
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Exclusion Criteria:
Drug: propofol 1mg/kg
Drug: Dexmedetomidine
Drug page: Propofol
1mg/kg propofol given 10 minutes before the end of surgery
0.3mcg/kg of dexmedetomidine to group D patients will be given after dilution with 10ml of 0.9%saline over 1 min given 10 minutes before extubation
Emergence Delirium PAED score
Time frame: PAED score will be calculated upon arrival in Post Anesthesia care unit then at 5,10,15,30 minutes interval
Plan to share: No — Ethical committe doesnt allow
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Studies of the drugs tested here: Propofol · Dexmedetomidine
Pakistan Institute of Medical Sciences