An interventional study of Academic Performance Feedback in Major Depression, Generalized Anxiety and Emotions, sponsored by University of Miami. Recruiting at 1 site in United States. Open to participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-23.
Sponsored by University of Miami · Not applicable, Interventional, and Basic science
This study utilizes mobile health methods, including smartphone technology, subjective self-reports measures of emotion, behavioral tasks, functional Magnetic Resonance Imaging (fMRI), physiological measures of attention and arousal, and measures of health and social support to identify neural mechanisms associated with individual differences in the temporal course of emotional responses. The aim of this project is to utilize real-world and personally relevant events as stimuli to better understand how the temporal course of emotional responses relate to risk for developing mental disorders.
2,805 studies on the registry are indexed under Depressive Disorder, Major; 565 are open to participants now.
This study's planned enrollment of 144 is above the median of 80 across 2,338 interventional studies indexed under Depressive Disorder, Major.
Browse Depressive Disorder, Major studies →University of Miami is the lead sponsor of 838 studies on the registry; 164 are open to participants now.
Of its 114 completed or terminated interventional studies of FDA-regulated products, 96 (84%) have results posted.
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Participants undergo up to six study visits during one academic semester, including baseline and post-examination MRI assessments. During MRI sessions, participants anticipate and receive actual midterm examination grades while neural and physiological responses are measured. Participants also complete repeated mobile mood assessments and self-report measures throughout the semester.
Behavioral: Academic Performance Feedback
Participants receive personally relevant academic performance feedback (actual midterm examination grades) during fMRI assessments. During each scan session, participants undergo a period of grade anticipation followed by disclosure of their exam grade while neural activity, physiological responses, and emotional experiences are assessed. The intervention is administered during repeated MRI sessions conducted over a single academic semester.
Mean Duration of fMRI-Derived Negative Emotional Brain States
Mean duration, measured in seconds, of fMRI-derived negative emotional brain states identified using hidden Markov modeling of default mode and salience network activity during academic performance feedback assessments.
Time frame: Baseline and end of academic semester (approximately 17 weeks)
Plan to share: Yes — The proposed research will generate data including self-report, structured interviews, and FMRI measures from young adults. Data will be publicly shared via datalad.org within 1 year after data collection is completed. Data will be linked to one another and connected to code via github. This approach is the currently recommended approach by the Center for Reproducible Neuroscience at Stanford. Code will be uploaded to the lab's github page.
Supporting information: Study protocol, Analytic code
Time frame: 1 year after study is completed
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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