Depressive Disorder, Major: all 2,805 studies
Page 1 of 29. Open to participants first (565), then studies with results posted, then the rest; newest registration first within each.
- Neural Mechanisms of Real-world Emotions and InternalizingRecruitingNCT07891624Not applicable
- Testing a Non-Deceptive Placebo Intervention for Subclinical Depressive SymptomsNot yet recruitingNCT07889908Not applicable
- Evaluation of a Multi-Layered Digital Phenotyping, Digital Safety Plan, and Pharmacogenomic Intervention for Suicide Prevention in Adults With DepressionRecruitingNCT07885722Not applicable
- French Minds Cohort: a French Longitudinal and Multimodal Cohort of Patients With Major Mood Disorders, Psychotic Disorders, Autism Spectrum Disorders, and Healthy ControlsRecruitingNCT07881016Not applicable
- Digital Phenotypes for Predicting Depression_ValidationEnrolling by invitationNCT07880015
- Dual Neuromodulation for Depression: Boosting TMS With tESNot yet recruitingNCT07879924Not applicable
- A Mobile App to Support Mood, Daily Routines and Medication Adherence in Adults With Severe Mental IllnessNot yet recruitingNCT07879131Not applicable
- Comparing 10 Hz rTMS and iTBS for Adolescent DepressionRecruitingNCT07873060Not applicable
- EEG-Guided Transcranial Magnetic Stimulation for Adults With DepressionNot yet recruitingNCT07862205Not applicable
- Brief Psychoanalytic Therapy Versus Cognitive Behavioral Therapy for Major Depressive DisorderNot yet recruitingNCT07857629Not applicable
- Effect of TMS Treatment on Defense Mechanisms and Functionality in Patients With DepressionNot yet recruitingNCT07853989
- Predictors of Treatment Outcome in Major Depressive DisorderNot yet recruitingNCT07853365
- Precision Depression Adalimumab TrialRecruitingNCT07845604Phase 2
- Personalized Accelerated iTBS Versus Sham for Major Depressive DisorderNot yet recruitingNCT07843875Not applicable
- Helping Kentuckians Overcome Depression and Opioid Addiction With Brain StimulationNot yet recruitingNCT07842601Not applicable
- Home-Based Randomized Trial of Spaced Transcranial Direct Current Stimulation for Treatment-Resistant DepressionNot yet recruitingNCT07834762Not applicable
- Amygdala-Targeted Transcranial Temporal Interference Stimulation for Major Depressive Disorder: A Randomized Sham-Controlled Trial of Clinical Efficacy and Neurobiological MechanismsNot yet recruitingNCT07829575Not applicable
- Longitudinal Effects of Brain Stimulation on Decision-Making and Reward LearningNot yet recruitingNCT07823218
- Study on iTBS Regulating the Reward Circuit Function to Improve Anhedonia in DepressionRecruitingNCT07813169Not applicable
- Intramuscular Ketamine for Suicidal Patients in the Evanston Hospital Emergency Department for Suicidal DistressEnrolling by invitationNCT07810023Not applicable
- Individual Narratives of Stimulation (ECT and TMS)Not yet recruitingNCT07807930
- Evaluation of an 8-week Behavior Skills-based Virtual Reality Program for Adolescents With Depression. (MDD)Not yet recruitingNCT07807735Not applicable
- Evaluation of the Acceptability, Feasibility and Exploration of the Efficacy of an Integrated Care Pathway CARIBOUNot yet recruitingNCT07806825Not applicable
- Individualized fMRI-guided TMS for DepressionNot yet recruitingNCT07804459Early Phase 1
- Behavioural Activation Therapy and Ketamine for Treatment-Resistant DepressionNot yet recruitingNCT07801703Phase 2/3
- Prescribing the Right Agent for Depression in AdultsNot yet recruitingNCT07796295Not applicable
- Oral Thiamine (Vitamin B1) for Depression in Children and AdolescentsNot yet recruitingNCT07793071Phase 2
- REWIRE: Real-world Engagement With Interventional and Rejoyn EffectivenessNot yet recruitingNCT07792252
- Adjunctive Probiotic Therapy in Major Depressive Disorder (ProMOOD)Not yet recruitingNCT07786285Not applicable
- Single Day of Ultra-accelerated TMS With a Single Dose of NRX-101Not yet recruitingNCT07785102Early Phase 1
- Early Detection of Perinatal Depression With Wearable TechnologyNot yet recruitingNCT07784244Not applicable
- Precision Closed-loop Brain-Computer Interface Neuromodulation for Treatment-Resistant DepressionNot yet recruitingNCT07783906Not applicable
- Identifying Biomarkers of Response to Digital Interventions for Mood DisordersEnrolling by invitationNCT07783633Not applicable
- Study of Lurasidone as Adjunctive Treatment in Patients With Major Depressive Disorder With Inadequate Response to Antidepressant MonotherapyNot yet recruitingNCT07781293Phase 3
- The Medically Tailored Groceries and Mental Health StudyRecruitingNCT07779707Not applicable
- Home-Based Wearable rTMS Therapy for Moderate to Severe DepressionNot yet recruitingNCT07775586Not applicable
- A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive DisorderRecruitingNCT07775300Phase 3
- A Study to Evaluate BMS-986511 in Adults With Major Depressive DisorderNot yet recruitingNCT07772531Phase 2
- Role of Kynurenine Pathway and Its Metabolites in Depressive Disorders, Major Depressive Disorder is Suspected to Have the Greatest Burden by 2030,Kynurenine Pathway is Major Route Through Which the Essential Amino Acid Tryptophan is Metabolised and Activated in Time of Stress and Immune Activation.Not yet recruitingNCT07771517
- Accelerated Versus Standard Intermittent Theta Burst Stimulation for Major Depressive DisorderRecruitingNCT07768397Not applicable
- Optimizing Treatment for Depressed Parents of Children With Emotional and Behavioural ProblemsRecruitingNCT07749521Not applicable
- EEG Microstate Parameters and Neuroinflammatory Biomarkers in Patients With Treatment-Resistant Major Depressive Disorder Receiving ECTRecruitingNCT07748091
- A Study of Lumateperone Versus Placebo in Participants With Major Depressive DisorderNot yet recruitingNCT07747389Phase 3
- Assessing of Behavioral Risk and Response to Electromagnetic and Psychedelic TherapiesNot yet recruitingNCT07745569Phase 2
- Tracking Risk in Adolescents and Children for Early Identification of Common Mental DisordersNot yet recruitingNCT07744490
- Context-Guided Personalized iTBS for DepressionNot yet recruitingNCT07743398Not applicable
- Compare the Efficacy and Safety of KH607 Tablets Versus Vortioxetine Hydrobromide Tablets in Adult Patients With Major Depressive DisorderNot yet recruitingNCT07741331Phase 3
- A Study of KH607 as Monotherpy in Adults Participants With Major Depressive DisorderNot yet recruitingNCT07741240Phase 3
- EEG Microstate and Neuroinflammatory Biomarkers in Older Age Patients With Major Depressive Disorder Receiving ECTRecruitingNCT07740694
- Biomarkers and Pharmacogenomics for Precision Depression TherapyNot yet recruitingNCT07738497Not applicable
- iMORE+ Study: A Multi-Omics Cohort Study of Major Depressive DisorderNot yet recruitingNCT07735143
- Pregnenolone Treatment for Alcohol Use Disorder and Major Depressive DisorderNot yet recruitingNCT07734701Phase 2
- Augmented Depression Therapy (ADepT) Case SeriesNot yet recruitingNCT07733310Not applicable
- Probiotic IBNI617 for Moderate to Severe DepressionNot yet recruitingNCT07728253Not applicable
- Effectiveness of Clustered Versus Tapered Repetitive Transcranial Magnetic Stimulation (rTMS) as Maintenance Therapy Following Successful Acute rTMS Treatment in Patients With Depressive SyndromeNot yet recruitingNCT07727005Not applicable
- Temporal Interference Transcranial Alternating Current Stimulation for Major Depressive DisorderNot yet recruitingNCT07712159Not applicable
- Effect of Psilocybin and Structured Integrated Reframing Therapy on Gut-Brain Axis Biomarkers and Depression in Major Depressive DisorderRecruitingNCT07703722Phase 3
- Cannabidiol Oil for Treatment-Resistant Major DepressionRecruitingNCT07696871Phase 1/2
- Repeated Real-time Biofeedback With 7-Tesla MRI for Treatment of DepressionRecruitingNCT07694076Not applicable
- Effect of Psychobiotics With Standard Antiddepressants in Treatment of Major Depressive DisorderRecruitingNCT07691749Not applicable
- Pregnenolone for Cannabis Use Disorder and DepressionNot yet recruitingNCT07685964Phase 1/2
- Intern Health Study 2026Enrolling by invitationNCT07685925Not applicable
- Longitudinal Study on the Sustainability of Transcranial Magnetic Stimulation Protocols - BiomarkersRecruitingNCT07684911
- Regulated Stimulation for Optimized Network Activity and Therapeutic Equilibrium - MaintenanceNot yet recruitingNCT07684794Not applicable
- Accelerated iTBS for PTSD and DepressionRecruitingNCT07682207Not applicable
- Type D Personality and Life Satisfaction in Bipolar Disorder Type 2 and Major Depressive DisorderRecruitingNCT07679204
- Relationship of Peripheral Inflammatory and Neuroprotective Biomarkers With Response to Intermittent Theta Burst Stimulation in Treatment-Resistant DepressionRecruitingNCT07673913Not applicable
- Using Fenfluramine to Test the Serotonin Deficiency Theory of DepressionNot yet recruitingNCT07651293Not applicable
- Non-Coding RNAs Gene Expression in Psychiatric DisordersNot yet recruitingNCT07649993
- Sertraline Combined With Multi-Strain Probiotics for Adolescent DepressionRecruitingNCT07645157Phase 2
- Stronger Together: Antenatal Depressive Symptoms - Prevalence and Digital TreatmentNot yet recruitingNCT07639164Not applicable
- Serotonin Variants & Gut Microbiota in Mental HealthNot yet recruitingNCT07634458
- Magnesium Bisglycinate in Major Depressive DisorderRecruitingNCT07633080Not applicable
- Functional Electrical Stimulation for MDDNot yet recruitingNCT07629050Not applicable
- Youth Suicide Prevention: CAMS-BI vs. Safety Planning in a Randomized TrialNot yet recruitingNCT07628192Not applicable
- The Effects of Aerobic Exercise and Mindful Breathing on Individuals With Major Depressive Disorder in Saudi ArabiaNot yet recruitingNCT07625163Not applicable
- Lumateperone for Late-Life DepressionRecruitingNCT07623135Phase 3
- A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)RecruitingNCT07621237Phase 2
- AI-Supported Therapy for Depression and Anxiety Compared With Standard CBTNot yet recruitingNCT07620340Not applicable
- Comparing Outcomes of Theta Burst Stimulation in Depression Using Advanced PET ImagingNot yet recruitingNCT07620288Not applicable
- Flumazenil for Benzodiazepine Reversal in Electroconvulsive TherapyRecruitingNCT07619092Not applicable
- Student Precarity and PsychiatryNot yet recruitingNCT07618208
- Efficacy and Safety of Transcranial Temporal Interference Stimulation for DepressionNot yet recruitingNCT07612501Not applicable
- EEG Prediction and Clinical Efficacy of tDCS in Major DepressionRecruitingNCT07611773Not applicable
- Multimodal MRI Study of Acupuncture's Rapid Antidepressant Mechanisms and Response Prediction in DepressionNot yet recruitingNCT07611487Not applicable
- Stress Management and Meditative Movements for Asian Americans With Depression and Physical SymptomsRecruitingNCT07610928Not applicable
- A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With DepressionRecruitingNCT07610473Phase 2
- Validation of the CIDI 5.0 Against the SCID-5 for Lifetime Mental DisordersRecruitingNCT07604753
- Accelerated iTBS for Major DepressionRecruitingNCT07603804Not applicable
- Multimodal Pharmacological Study of Clinical Cohorts for Major Depressive DisorderNot yet recruitingNCT07602153
- Multi-site Feasibility of an Integrated Treatment for the Biology and Experience of Depression: The MULTIBED StudyNot yet recruitingNCT07596914Not applicable
- Regulated Stimulation for Optimized Network Activity and Therapeutic EquilibriumRecruitingNCT07594483Not applicable
- Synaptic Mechanisms of Intermittent Theta Burst Stimulation for Major Depressive DisorderNot yet recruitingNCT07593222Phase 1/2
- A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)RecruitingNCT07592689Phase 3
- Personalized Pharmaco-Lifestyle Interventions for Severe Mental Illnesses (LIFETRAIN)Not yet recruitingNCT07586150Not applicable
- Effect of Vitamin D Supplementation on Brain Waves in Female Major Depressive Disorder Patients With Hypovitaminosis DEnrolling by invitationNCT07579078Not applicable
- A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive DisorderRecruitingNCT07573176Phase 3
- tDCS: Sleep to Mood in Depression (S2M-D)RecruitingNCT07572526Not applicable
- Identification and Molecular Characterisation of Urban-environmental Stress Patterns Affecting Mental IllnessRecruitingNCT07571226
- Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT)RecruitingNCT07569198Phase 2