Massachusetts General Hospital: Depressive Disorder, Major trials

The registry lists 79 Depressive Disorder, Major studies with Massachusetts General Hospital as lead sponsor. 8 are open to participants now and 33 have results posted.

Early Phase 1 1Phase 1 1Phase 2 14Phase 3 4Phase 4 12No phase 48(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Oral Thiamine (Vitamin B1) for Depression in Children and AdolescentsNot yet recruitingNCT07793071Phase 2
• Stress Management and Meditative Movements for Asian Americans With Depression and Physical SymptomsRecruitingNCT07610928Not applicable
• Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via InfliximabRecruitingNCT06136546Phase 2
• Adapting the Tumor Board Model for Mental Illness and CancerRecruitingNCT05837598Not applicable
• Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIVRecruitingNCT05570812Phase 2
• Targeting Specific Brain Networks to Treat Specific Symptoms in DepressionRecruitingNCT05523817Not applicable
• Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With DepressionRecruitingNCT05450432Phase 4
• Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric PopulationsRecruitingNCT04296604Not applicable
• Therapist-Guided Smartphone-Delivered CBT for MDDCompletedNCT05386329Not applicableResults posted
• Vagus Nerve Stimulation: Integration of Behavior and Cardiac ModulationCompletedNCT04467164Not applicableResults posted
• Impact of Transcutaneous Vagal Nerve Stimulation on Stress Response in Major DepressionCompletedNCT04448327Not applicableResults posted
• Improving Attentional and Cognitive Control in the Psychological Treatment of Intrusive ThoughtsCompletedNCT04225624Not applicableResults posted
• Bridge: Proactive Psychiatry Consultation and Case Management for Patients With CancerCompletedNCT03360695Not applicableResults posted
• Transcranial Laser Therapy, Continuous and Pulsed Light, for Major Depressive Disorder (ELATED-3)CompletedNCT02959307Not applicableResults posted
• Augmentation of Treatment-Resistant Depression With An Analog of the Neuroactive Steroid AllopregnanoloneCompletedNCT02900092Not applicableResults posted
• Integrated Smoking Cessation Treatment for Smokers With Serious Mental IllnessCompletedNCT02845440Not applicableResults posted
• Hyperthermic Yoga for Depressive SymptomsCompletedNCT02607514Not applicableResults posted
• Omega-3 Fatty Acids for Major Depressive Disorder With High Inflammation: A Personalized ApproachCompletedNCT02553915Phase 2/3Results posted
• Ketamine for Depression: An MRI StudyCompletedNCT02544607Phase 4Results posted
• Investigation of Brain Network Dynamics in DepressionCompletedNCT01931995Not applicableResults posted
• Low-Dose Naltrexone (LDN) for Depression Relapse and RecurrenceCompletedNCT01874951Phase 2Results posted
• Neurobiological Bases of Placebo Response in Major Depressive DisorderTerminatedNCT01787240Phase 4Results posted
• Ketamine Versus Placebo for Treatment Resistant Major Depressive DisorderCompletedNCT01667926Not applicableResults posted
• Ketamine Infusion for Treatment-resistant Major Depressive DisorderCompletedNCT01582945Not applicableResults posted
• Stimulant Enhancement of Well-Being Therapy for DepressionTerminatedNCT01478113Not applicableResults posted
• Study of Probiotic GanedenBC30 for Irritable Bowel Syndrome and Major Depressive DisorderTerminatedNCT01337609Phase 4Results posted
• Efficacy and Safety of Cranial Electrical Stimulation (CES) for Major Depressive Disorder (MDD)CompletedNCT01325532Not applicableResults posted
• N-methyl-D-aspartate Antagonist (Ketamine) Augmentation of Electroconvulsive Treatment for Severe Major DepressionTerminatedNCT01260649Phase 4Results posted
• Pilot Study of Open-label Placebo to Treat Major Depressive DisorderCompletedNCT01103271Phase 2Results posted
• Seroquel Alone Versus Seroquel With an SSRI for Depression With Psychotic SymptomsTerminatedNCT00955474Phase 4Results posted
• Quantitative Electroencephalogram (QEEG) Predictors of Response to Psychotherapy Versus Antidepressant Treatment in DepressionCompletedNCT00824044Phase 4Results posted
• Open Label Extension Assessing the Tolerability of BCI-024 in Combination With BCI-049 in Patients With Major Depressive Disorder (MDD)CompletedNCT00731653Phase 2Results posted
• Efficacy and Safety Study of a Combination Product [Drug:BCI-024 (Buspirone) and Drug:BCI-049 (Melatonin)] to Treat Major Depressive Disorder (MDD)CompletedNCT00705003Phase 2Results posted
• A Double-Blind, Placebo-Controlled Study of Aripiprazole Adjunctive to Antidepressant TherapyCompletedNCT00683852Phase 3Results posted
• Ziprasidone Augmentation of SSRIs for Patients With Major Depressive Disorder (MDD) That do Not Sufficiently Respond to Treatment With SSRIsCompletedNCT00633399Phase 2Results posted
• A 12-Week, Placebo Controlled Trial of Ziprasidone as Monotherapy for Major Depressive DisorderCompletedNCT00555997Phase 2Results posted
• Investigating the Effectiveness of Telepsychiatry for Treating Major Depression in a Chinese American Nursing HomeCompletedNCT00505518Not applicableResults posted
• Brain GABA Levels and Treatment Response in Major Depressive DisorderCompletedNCT00464711Phase 4Results posted
• Acamprosate Added to Escitalopram and Behavioral Treatment for Comorbid Depression and AlcoholismCompletedNCT00452543Phase 4Results posted
• Safety and Effectiveness of Omega 3-Fatty Acids, EPA Versus DHA, for the Treatment of Major DepressionCompletedNCT00361374Phase 3Results posted
• Biological Markers of Response to Treatment in Major Depressive DisorderCompletedNCT00361218Phase 3Results posted
• Specialized Pro-resolving Lipid Mediators and Treatment Resistant DepressionActive, not recruitingNCT05774665Phase 2
• Clinical Validation of Samsung SmartwatchActive, not recruitingNCT05767593
• The Effects of Psilocybin on Self-Focus and Self-Related Processing in Treatment Resistant MDDWithdrawnNCT05381974Phase 2
• Peripheral Neuroimmune Mechanisms of HyperthermiaStatus unknownNCT05366270Not applicable
• Effects of Respiratory-Gated Transcutaneous Vagal Nerve Stimulation in Major Depression (Phase 1)CompletedNCT04607226Not applicable
• Waitlist-Control Trial of Smartphone CBT for Major Depressive Disorder (MDD)WithdrawnNCT04594616Not applicable
• Mechanism of Action of Transcranial Magnetic StimulationActive, not recruitingNCT04278521Not applicable
• Mild-Intensity Whole Body Hyperthermia (WBH) for Major Depressive DisorderSuspendedNCT03787290Phase 2
• Waitlist-Control Trial of Smartphone CBT for Major Depressive Disorder (MDD), WithdrawnWithdrawnNCT03769350Not applicable
• Comparative Effectiveness of Pharmacogenomics for Treatment of DepressionCompletedNCT03749629Not applicable
• Xenon Inhalation Therapy for Major Depressive Disorder and Bipolar DisorderCompletedNCT03748446Early Phase 1
• The Role of Cognitive Control in the Transdiagnostic Conceptualization of "Intrusive Thoughts"CompletedNCT03414619Not applicable
• Adapted Cognitive Behavioral Treatment for Depression in Patients With Moderate to Severe Traumatic Brain InjuryCompletedNCT03307070Not applicable
• Translational Investigation of Gestational Environment on Neurobehavioral Function in ChildrenCompletedNCT02715778
• Proactive Psychiatry Consultation for Patients With Cancer and Severe Mental IllnessCompletedNCT02594696Not applicable
• Noninvasive Physiologic Sensors to Assess DepressionCompletedNCT02568865
• Mood Patient Powered Research Network (MoodNetwork)CompletedNCT02453438
• Self Focus in Bipolar Disorder: A Functional Magnetic Resonance Imaging (fMRI) StudyCompletedNCT02253225
• The Effects of Vilazodone on Glutamate in the Anterior Cingulate Cortex in Anxious Unipolar DepressivesWithdrawnNCT02028026Phase 4
• Trial of a Positive Psychology Intervention in Major Depressive DisorderCompletedNCT02004145Not applicable
• Effectiveness and Acceptability of MoodGYM in Treating Depressive Symptoms in Chinese AmericansCompletedNCT01851967Not applicable
• Ketamine and Scopolamine Infusions for Treatment-resistant Major Depressive DisorderWithdrawnNCT01613820Not applicable
• ON/OFF Stimulation and Reward Motivation in Patients With Deep Brain StimulatorsCompletedNCT01590862Not applicable
• Complex Dynamic Systems in Mood DisordersCompletedNCT01583569
• Potential Use Of Brain Network Activation Analysis to Diagnose Major DepressionTerminatedNCT01579942
• ON/OFF Stimulation and Impulsivity in Patients With Deep Brain StimulatorsWithdrawnNCT01506206
• Mindfulness Based Cognitive Therapy for Chronic Pain and Comorbid Unipolar DepressionStatus unknownNCT01473615Not applicable
• Internet-Based Depression Screening for College StudentsCompletedNCT01326793Not applicable
• Risks for Insulin Resistance and Metabolic Syndrome Between Major Depressive Disorder (MDD) or MDD With Psychotic FeaturesTerminatedNCT01310140
• Tai Chi Training for Treating Depressed Chinese AmericansCompletedNCT01263730Not applicable
• Computerized Information-Processing Bias Retraining in Depressed AdolescentsCompletedNCT01147913Phase 2
• Photobiomodulation to Alter Cerebral Blood Flow and to Affect the Emotional Status of Patients With Major DepressionCompletedNCT00961454Phase 1
• Cognitive Deficits in Major Depressive Disorder and Bipolar Disorder, Depressed Type: Prevalence and Improvement With Treatment of Depressive SymptomsCompletedNCT00844974Not applicable
• Neural Correlates of Psychodynamic Psychotherapy for DepressionCompletedNCT00812227Not applicable
• Exploring a Potential Blood Test to Diagnose Major Depressive DisorderCompletedNCT00705185
• Biochemical Brain Changes Correlated With The Antidepressant Effect Of Thyroid HormonesCompletedNCT00562367Not applicable
• A Study of 6(S)-5-MTHF Among Serotonin Reuptake Inhibitor(SSRI)-Resistant Outpatients With Major Depressive Disorder (MDD)CompletedNCT00321152Phase 4
• Quantitative EEG (QEEG) as a Predictor of Treatment Outcome in DepressionCompletedNCT00157547Phase 4