Chronic Cough clinical trials
The registry lists 142 studies for Chronic Cough across more than 10 countries. 39 are recruiting or about to start. 109 of them are mainly about Chronic Cough (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-05.
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Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
Merck Sharp & Dohme LLC (7) · McMaster University (7) · Afferent Pharmaceuticals, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (6) · University of Montana (5) · GlaxoSmithKline (5) · Mayo Clinic (5) · Bellus Health Inc. - a GSK company (4) · Bayer (4)
What is being tested here
Drugs under test in Chronic Cough studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 9, phase 3 first
- Aug 2027A 24-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough - China Extension · Phase 3 · GlaxoSmithKline
- Dec 2026Efficacy of Two Doses of Duloxetine and Amitriptyline in Subjects With Refractory Chronic Cough · Mayo Clinic
- Dec 2026China Chronic Cough Registry: a Multicenter, Prospective, Observational Study · The First Affiliated Hospital of Guangzhou Medical University
- Jan 2027A Study to Investigate the Efficacy and Safety of SC0032, a Magnesium Salt Oral Spray, in Adults With Refractory or Unexplained Chronic Cough · Sensory Cloud, Inc.
- Mar 2027Sputum Cytometry Guided Management for the Elimination of Chronic Cough in Patients With ILD · McMaster University
- Mar 2027Efficacy of Behavioral Therapy for Chronic Refractory Cough · Assiut University
- Jun 2027Stimulation of the Larynx to Treat Unexplained Chronic Cough · University of Minnesota
- Jun 2027Efficacy of Intramuscular Steroid Injection for Chronic Cough. · Medical University of South Carolina
- Sep 2027The Effect of Nalbuphine Extended-Release (NAL ER) on Cough in Participants With Refractory Chronic Cough (RCC) · Trevi Therapeutics
Who these studies take
Of the 30 Chronic Cough studies recruiting now, 10 (33%) set no upper age limit and 11 (37%) stop at 75 or younger. 3 (10%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 5 (17%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (7%) | 2 (7%) |
| 18 | 24 (80%) | 24 (80%) |
| 30 | 27 (90%) | 27 (90%) |
| 40 | 27 (90%) | 27 (90%) |
| 50 | 27 (90%) | 27 (90%) |
| 65 | 26 (87%) | 26 (87%) |
| 75 | 22 (73%) | 22 (73%) |
| 85 | 14 (47%) | 14 (47%) |
Across all 142 studies, recruiting or not: 32% stop at 75 or younger and 17% at 65; 11% take children; 1% are for women only and 1% for men only; 22% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Chronic Cough studies take
Of 25 phase 2 interventional studies under Chronic Cough, half reached primary completion within 11 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 11 mo10–21 · 25 studies | — | — |
| Interventional, no phase | 20 mo7–48 · 20 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting1
Studies
Recruiting first, then most recently updated. Showing 50 of 142. Browse all 142 → or search them.
- Office-Based Superior Laryngeal Nerve Block for Treatment of Neurogenic CoughRecruitingNCT046423521 country
- The Effect of Nalbuphine Extended-Release (NAL ER) on Cough in Participants With Refractory Chronic Cough (RCC)RecruitingNCT07671924Phase 22 countries
- Feasibility, Acceptability, and Safety Trial of Brief, Breath Control-Focused Acceptance and Commitment Therapy in Adults With Chronic CoughRecruitingNCT07566117Not applicable1 country
- A 2x2 Factorial, Randomized, Open-label Trial to Evaluate Neuromodulators and Cough Control Therapy in Patients With Refractory or Unexplained Chronic CoughNot yet recruitingNCT07288528Phase 41 country
- A Study to Investigate the Efficacy and Safety of SC0032, a Magnesium Salt Oral Spray, in Adults With Refractory or Unexplained Chronic CoughRecruitingNCT07690059Phase 21 country
- Sputum Cytometry Guided Management for the Elimination of Chronic Cough in Patients With ILDRecruitingNCT05086432Not applicable1 country
- Canadian Consortium on Airway Mucus Occlusions in Asthma, COPD and Chronic CoughRecruitingNCT068587481 country
- Mechanisms of Change in Behavioral Cough Suppression Therapy for Refractory Chronic CoughRecruitingNCT06960759Phase 21 country
- Biomarkers and Respiratory Omics as New CHildren Opportunities - Study of Clinical Outcomes and Predictivity EvaluationRecruitingNCT072325501 country
- Efficacy of Intramuscular Steroid Injection for Chronic Cough.RecruitingNCT06634823Early Phase 11 country
- Remodelling of the Lower Airways in Chronic CoughRecruitingNCT076598601 country
- A 24-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough - China ExtensionRecruitingNCT07650084Phase 31 country
- Stimulation of the Larynx to Treat Unexplained Chronic CoughRecruitingNCT05273190Not applicable1 country
- Finnish Children´s Protracted CoughRecruitingNCT07582549Phase 31 country
- Effects of Energy Versus Mechanical Surgical Devices on Postoperative CoughNot yet recruitingNCT07524712Not applicable1 country
- Efficacy of Behavioral Therapy for Chronic Refractory CoughRecruitingNCT07488598Not applicable1 country
- A Phase 2 Study of HW091077 in Participants With Refractory Chronic Cough Or Unexplained Chronic Cough (RCC/UCC).Not yet recruitingNCT07483489Phase 2
- Comprehensive Analysis of the Swallowing Mechanism Using High-resolution Manometry With ImpedanceNot yet recruitingNCT07365046Not applicable1 country
- Efficacy of Two Doses of Duloxetine & Amitriptyline in Interstitial Lung Disease-related CoughRecruitingNCT05120934Phase 21 country
- Efficacy of Two Doses of Duloxetine and Amitriptyline in Subjects With Refractory Chronic CoughRecruitingNCT05110144Phase 21 country
- Wenjuanxing-Based Multidimensional Etiologic Screening and Clinical Validation of Chronic Cough in ChildrenNot yet recruitingNCT073066371 country
- A Prospective, Randomized, Double-blind Study on the Effects of Different Anesthesia Strategies on Postoperative Cough in Patients Undergoing Video-assisted Thoracoscopic Surgery.Not yet recruitingNCT07190664Not applicable
- Validation of a Questionnaire to Measure Cough SeverityRecruitingNCT066698971 country
- Cough Management Wellness App for Refractory or Unexplained Chronic CoughRecruitingNCT07070895Not applicable1 country
- The Safety, Feasibility, and Repeatability of Inhaled ATP Cough ChallengesRecruitingNCT07085975Phase 11 country
- An Observational Study Using Novel Questionnaire to Characterize Cough Phenotypes in Patients With Chronic CoughRecruitingNCT063764481 country
- Investigating the Role of ATP Production by Airway Epithelium in Patients With Refractory and Unexplained Chronic Cough (RCC/UCC).RecruitingNCT066006461 country
- A Non-pharmacological Cough Control TherapyRecruitingNCT04767074Not applicable1 country
- China Chronic Cough Registry: a Multicenter, Prospective, Observational StudyNot yet recruitingNCT068623621 country
- Neuroinflammatory Interactions of ATP and P2X3 Receptor in the Airways of Chronic Cough PatientsRecruitingNCT062861631 country
- The Real-world Treatment Satisfaction by Gefapixiant in RCCRecruitingNCT06542484Not applicable1 country
- Chronic COUGH Management in Interstitial Lung DisEaseNot yet recruitingNCT06782893Not applicable1 country
- Group Telehealth Behavioral Cough Suppression TherapyRecruitingNCT06706765Early Phase 11 country
- Effects of Vagus Nerve Pulmonary Branch Block on Postoperative Cough After VATS Lung ResectionRecruitingNCT06500949Not applicable1 country
- Effect of Gefapixant on Cough-related Brain Activity in Patients With Chronic CoughRecruitingNCT05813223Early Phase 11 country
- Single-center Clinical Study on the Safety and Effect of Bronchoscopic Cryotherapy in Patients With Chronic CoughRecruitingNCT06378671Not applicable1 country
- A Phase Ib/II Clinical Study in Patients With Refractory Chronic CoughNot yet recruitingNCT06213363Phase 1/2
- Individualized Diagnosis and Treatment of Extraesophageal Reflux in Patients With Chronic CoughRecruitingNCT04984304Not applicable1 country
- Analysis of the Reliability and Validity of the Chinese Version of CC-QoLRecruitingNCT053620971 country
- Cross-sectional Characterization of Idiopathic BronchiectasisCompletedNCT012640552 countries
- Etiology Analysis of Chronic Cough After COVID-19 Infection and Research on the Efficacy of ICS or ICS/LABACompletedNCT065039391 country
- Inhaled vs Intranasal Corticosteroids for Chronic Cough in Upper Airway Cough SyndromeCompletedNCT07777796Not applicable1 country
- A Study to Investigate the Difference In Blood Levels of Camlipixant Between Different Camlipixant Formulation PrototypesWithdrawnNCT07684586Phase 11 country
- Impact of Refractory Chronic Cough on Activities of Daily Living and Response to Acute High-intensity ExerciseTerminatedNCT067661751 country
- A 52-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic CoughCompletedNCT05599191Phase 315 countries
- A 24-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic CoughActive, not recruitingNCT05600777Phase 313 countries
- Study to Assess the Efficacy, Safety, and Tolerability of NOC-110 in Adults With Refractory or Unexplained Chronic CoughActive, not recruitingNCT06504446Phase 26 countries
- Chronic Cough and Small Fiber NeuropathyTerminatedNCT03787511Not applicable1 country
- COllaboration REsearch on Chronic Cough (COREC): a French Multicenter DatabaseTerminatedNCT048829431 country
- Refractory Chronic Cough Improvement Via NAL ER (RIVER)CompletedNCT05962151Phase 22 countries