Coma clinical trials
The registry lists 138 studies for Coma across more than 10 countries. 35 are recruiting or about to start. 54 of them are mainly about Coma (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09. Counting its narrower condition Brain Death too: 210 studies, 45 open.
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Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
Assistance Publique - Hôpitaux de Paris (9) · Massachusetts General Hospital (5) · Hospices Civils de Lyon (5) · University Hospital, Toulouse (3) · University of California, Los Angeles (3) · Life Recovery Systems (3) · Rijnstate Hospital (3) · University Hospital, Bordeaux (3)
What is being tested here
Drugs under test in Coma studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Sodium Lactate | 1 | 0 | 1 |
| Amantadine | 0 | 0 | 2 |
| Methylphenidate | 0 | 0 | 1 |
| Acetaminophen | 0 | 0 | 1 |
| Ibuprofen | 0 | 0 | 1 |
| Minocycline | 0 | 0 | 1 |
| Rocuronium | 0 | 1 | 1 |
| Exenatide | 0 | 0 | 1 |
| Alanylglutamine | 0 | 0 | 1 |
| Apomorphine | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 5
- Dec 2026fNIRS for Disorders of Consciousness · University of California, Los Angeles
- Dec 2026Rapid-Response EEG in Children With Suspected Status Epilepticus · Children's Hospital at Montefiore
- Feb 2027Brain-injured Patients Extubation Readiness Study · University Hospital, Clermont-Ferrand
- Apr 2027Safety and Efficacy of Enhanced Recovery After Surgery in Neurocritical Care · Shanghai 6th People's Hospital
- Aug 2027Neuroprognostication Bias: A Collaboration to Reduce the Impact of Self-fulfilling Prophecy in Cardiac ARrEst · Boston Medical Center
Who these studies take
Of the 22 Coma studies recruiting now, 13 (59%) set no upper age limit and 5 (23%) stop at 75 or younger. 4 (18%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 4 (18%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (14%) | 3 (14%) |
| 18 | 20 (91%) | 20 (91%) |
| 30 | 20 (91%) | 20 (91%) |
| 40 | 20 (91%) | 20 (91%) |
| 50 | 20 (91%) | 20 (91%) |
| 65 | 20 (91%) | 20 (91%) |
| 75 | 19 (86%) | 19 (86%) |
| 85 | 15 (68%) | 15 (68%) |
Across all 138 studies, recruiting or not: 20% stop at 75 or younger and 13% at 65; 14% take children; 1% are for women only and 0% for men only; 13% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Coma studies take
Of 39 interventional studies with no phase under Coma, half reached primary completion within 39 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 39 mo17–54 · 39 studies | — | 39 mo17–54 · 39 studies |
| Observational | 34 mo14–60 · 24 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Started recruiting2
Newly registered1
- Minimal Sedation Versus Standard Continuous Sedation After Out-of-Hospital Cardiac ArrestOct 26, 2026NCT07895771
Studies
Recruiting first, then most recently updated. Showing 50 of 138. Browse all 138 → or search them.
- Assessment of Structural Brain Changes Related to Anoxic Coma Using High-field and Very Low Field Mobile MRIRecruitingNCT07177755Not applicable1 country
- The Coma Family Program (COMA-F): A Resilience Program for Caregivers of Patients With Severe Acute Brain InjuryRecruitingNCT07331324Not applicable1 country
- Minimal Sedation Versus Standard Continuous Sedation After Out-of-Hospital Cardiac ArrestRecruitingNCT07895771Not applicable1 country
- Pediatric Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (P-ICECAP)RecruitingNCT05376267Not applicable5 countries
- The EBC Recovery StudyRecruitingNCT047125911 country
- Kinetics and Prognostic Value of NeuroFilament Light in Post-cardiac Arrest: A Prospective Multicenter StudyNot yet recruitingNCT077606361 country
- Prognostication of Recovery in Early Disorders of Consciousness StudyEnrolling by invitationNCT07074678Not applicable1 country
- Multimodal Assessment and Prognosis in Disorders of Consciousness After Severe Brain Injury (CyDoC-MAP)Not yet recruitingNCT077368201 country
- Circadian Rhythmicity During Coma AwakeningRecruitingNCT06245434Not applicable1 country
- Vagus Nerve Stimulation in Patients in Comatose StateRecruitingNCT07719595Not applicable1 country
- Treatment of ELectroencephalographic STatus Epilepticus After Cardiopulmonary Resuscitation-2 (TELSTAR-2)RecruitingNCT06549426Not applicable2 countries
- Combined Whole-brain Structural and Functional MRI for the Prediction of Neurological Recovery After Cardiac ArrestRecruitingNCT06617377Not applicable1 country
- Promoting Recovery After Brain Injury Using Focused UltrasoundRecruitingNCT07277309Not applicable1 country
- fNIRS for Disorders of ConsciousnessRecruitingNCT074853611 country
- mindBEAGLE: Unlocking Functional Communication for Patients With Disorders of ConsciousnessEnrolling by invitationNCT06426602Not applicable1 country
- Recovery Trajectory for Coma and Disorders of ConsciousnessRecruitingNCT076140741 country
- Ultrasound Stimulation for Patients in a Disorder of ConsciousnessRecruitingNCT06939348Not applicable1 country
- Evaluation and Optimization of Telephone Triage Using Artificial Intelligence (AI) Models for the Detection of Demands for Time-dependent Pathology at the Emergency and Urgent Care Coordination Center (CCUE).RecruitingNCT072476691 country
- SeeMe: Using Automated Facial Tracking to Detect Voluntary Behavior in Brain InjuryRecruitingNCT07560631Not applicable1 country
- NEURO - Prognostication Using Late Somatosensory Evoked - PotentialsNot yet recruitingNCT07506928Not applicable1 country
- Sodium Lactate in Severe TBINot yet recruitingNCT06701760Phase 2
- Neuroprognostication Bias: A Collaboration to Reduce the Impact of Self-fulfilling Prophecy in Cardiac ARrEstRecruitingNCT032610892 countries
- Predictive Outcome in Comatose PatientsRecruitingNCT053214591 country
- Brain-injured Patients Extubation Readiness StudyRecruitingNCT04080440Not applicable1 country
- Emotional and Neutral Sounds for Neurophysiological Prognostic Assessment of Critically Ill Patients With a Disorder of ConsciousnessRecruitingNCT057407351 country
- Vagal Nerve Stimulation to Treat Disorders of ConsciousnessNot yet recruitingNCT07077135Not applicable1 country
- The Safety and Efficacy of Median Nerve Electrical Stimulation for Improving Neurological Function Prognosis in Patients With Cardiac ArrestNot yet recruitingNCT06696690Not applicable1 country
- Safety and Efficacy of Enhanced Recovery After Surgery in Neurocritical CareRecruitingNCT06241482Not applicable1 country
- A Study of Transcutaneous Electrical Stimulation As a Noxious Stimulus for the Glasgow Coma ScaleEnrolling by invitationNCT06681779Not applicable1 country
- Rapid-Response EEG in Children With Suspected Status EpilepticusRecruitingNCT065646621 country
- Evaluation of EEG Power Spectrum in Patients With Traumatic ComaNot yet recruitingNCT063211461 country
- The Effect of Auditory and Tactile Stimuli in Traumatic ComaNot yet recruitingNCT05195606Not applicable
- A New Approach in Intensive Care Unit Consciousness Assessment: FIVE ScoreNot yet recruitingNCT060367321 country
- Short-term Cervical Spinal Cord Stimulation in Patients With Disorders of Consciousness After Intracerebral HemorrhageRecruitingNCT05922644Not applicable1 country
- Imaging of the Neural Correlates of Arousal and AwarenessNot yet recruitingNCT04575454Not applicable1 country
- Lassa Fever Clinical Course and Prognostic Factors in NigeriaCompletedNCT036555611 country
- Effect of Virtual Reality Simulation on Nursing Students' Knowledge and Skill Performance in Respiratory Physical ExaminationCompletedNCT06536361Not applicable1 country
- Influence of Cooling Duration on Efficacy in Cardiac Arrest PatientsCompletedNCT04217551Not applicable1 country
- Feasibility of the Comfort Measures Only Time Out (CMOT)Active, not recruitingNCT05861323Not applicable1 country
- Comprehensive Observations and Multidisciplinary Approaches in the Management of Unconscious PatientsCompletedNCT062651681 country
- Predicting Mortality in Patients With Return of Spontaneous Circulation After Cardiac ArrestCompletedNCT070200911 country
- Direct or Subacute Coronary Angiography in Patients With Out of Hospital Cardiac Arrest Without Coma.TerminatedNCT04876222Not applicable2 countries
- Palpatory and Ultrasonographic Assessment of Tissue Compressibility: Validation and Learning Effects in Phantom ModelsActive, not recruitingNCT073867821 country
- Cracking Coma: Towards EEG and MRI Based Precision Medicine After Cardiac ArrestCompletedNCT033083051 country
- Effectiveness of Familiar Voices and Nature Sounds Among Critically Ill Comatose PatientsCompletedNCT06470802Not applicable1 country
- Neurological Complications and ICU Workload After Emergency Repair of Acute Type A Aortic DissectionCompletedNCT071676281 country
- Longitudinal Study of the Default-mode Network Connectivity in Brain Injured Patients Recovering From ComaCompletedNCT016209571 country
- Antiseizure Medication in Seizure Networks at Early Acute Brain InjuryTerminatedNCT06081283Phase 41 country
- Stimulant Therapy Targeted to Individualized Connectivity Maps to Promote ReACTivation of ConsciousnessActive, not recruitingNCT03814356Phase 11 country
- Beneficial Effects of Music on Cognition and Consciousness LevelCompletedNCT02742506Not applicable1 country