An interventional study of Intervention and Placebo in Fatigue, Low Mood and Mental Clarity, sponsored by Ancestral Supplements, LLC. Active, not recruiting at 1 site in United States. Open to participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-23.
Sponsored by Ancestral Supplements, LLC · Not applicable, Interventional, and Treatment
This is a randomized, triple-blind, placebo-controlled clinical trial evaluating the effects of the Ancestral Supplements Grass Fed Beef Liver oral supplement on energy, mood, and mental clarity over 12 weeks. One hundred male and female participants aged 18-50 who report concerns regarding energy levels, mood, and mental clarity will be enrolled and randomized equally into an intervention arm (beef liver supplement) or a placebo arm.
Participants will take their assigned product once daily and complete self-reported questionnaires at Baseline, Week 4, Week 8, and Week 12. Blood testing (iron panel) will be conducted at Baseline and Week 12 at a local Quest Diagnostics Clinic. The primary objective is to evaluate the product's effects on energy and mood; the secondary objective is to assess participants' perceptions of the product's effects on energy, mood, and mental clarity, including happiness, anxiety, well-being, brain fog, and concentration.
1,912 studies on the registry are indexed under Fatigue; 381 are open to participants now.
This study's enrollment of 100 is above the median of 53 across 1,479 interventional studies indexed under Fatigue.
Browse Fatigue studies →This is the only study on the registry with Ancestral Supplements, LLC as lead sponsor.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Dietary Supplement: Intervention
Dietary Supplement: Placebo
Participants receive the Ancestral Supplements Grass Fed Beef Liver supplement (Grass Fed Liver \[Bovine\], 3000 mg per serving of 6 capsules) taken once daily, with a graduated dose escalation from 1 capsule/day over the first 18 days up to the full serving of 6 capsules/day, for 12 weeks.
Participants receive a matched placebo product (microcrystalline cellulose and natural food color) taken once daily using the same dosing regimen as the intervention arm, for 12 weeks. The taste and appearance of the placebo are matched to the test product.
Change in Iron Status
Change in blood iron levels assessed via iron panel blood test (Quest Diagnostics, iron test code 001339)
Time frame: Baseline and Week 12
Change in Energy Levels
Change in self-reported energy levels assessed via self-reported questionnaire
Time frame: Baseline, Week 4, Week 8, and Week 12
Change in Mood
Change in self-reported mood assessed via self-reported questionnaire
Time frame: Baseline, Week 4, Week 8, and Week 12
Change in Self-Reported Vitality
Change in perceived vitality related to energy, mood, focus, and mental clarity assessed via self-reported questionnaire
Time frame: Baseline, Week 4, Week 8, and Week 12
Change in Self-Reported Happiness
Change in perceived happiness assessed via self-reported questionnaire
Time frame: Baseline, Week 4, Week 8, and Week 12
Change in Self-Reported Anxiety
Change in perceived anxiety assessed via self-reported questionnaire
Time frame: Baseline, Week 4, Week 8, and Week 12
Change in Self-Reported Well-being
Change in perceived well-being assessed via self-reported questionnaire
Time frame: Baseline, Week 4, Week 8, and Week 12
Change in Self-Reported Brain Fog
Change in perceived brain fog assessed via self-reported questionnaire
Time frame: Baseline, Week 4, Week 8, and Week 12
Change in Self-Reported Concentration
Change in perceived concentration assessed via self-reported questionnaire
Time frame: Baseline, Week 4, Week 8, and Week 12
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is active, not recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.