Syncope clinical trials
The registry lists 201 studies for Syncope across more than 10 countries. 36 are recruiting or about to start. 93 of them are mainly about Syncope (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-03. Counting its narrower condition Syncope, Vasovagal too: 256 studies, 55 open.
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Who runs them
Biotronik SE & Co. KG (9) · Istituto Auxologico Italiano (7) · Abbott Medical Devices (6) · Medtronic Cardiac Rhythm and Heart Failure (5) · University of Calgary (5) · National Institute of Neurological Disorders and Stroke (NINDS) (4) · Ottawa Hospital Research Institute (4) · NHS Lothian (3)
What is being tested here
Drugs under test in Syncope studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Ondansetron | 1 | 0 | 1 |
| Ampreloxetine | 0 | 3 | 3 |
| Clobazam | 0 | 2 | 2 |
| Midodrine | 0 | 1 | 2 |
| QCC374 | 0 | 0 | 2 |
| Mirabegron | 0 | 0 | 1 |
| Acarbose | 0 | 0 | 1 |
| Ajmaline | 0 | 0 | 1 |
| Propranolol | 0 | 0 | 1 |
| Metoprolol | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Dec 2026Study of Ondansetron in the Prevention of Sleep Syncope: The Nineth Prevention of Syncope Trial (POST9) · Phase 3 · University of Calgary
- Nov 2026Cardioneuroablation for Reflex Syncope and Exercise Capacity · Centre of Postgraduate Medical Education
- Dec 2026Syncope Trial to Understand Tilt Testing or ECG Recording Tenth Prevention of Syncope Trial · University of Calgary
- Dec 2026Global Approach to Faint and Falls · Istituto Auxologico Italiano
- Mar 2027Head-to-Head (H2H) Comparison of Ambulatory Cardiac ECG Monitors in Japan · iRhythm Technologies, Inc.
- Apr 2027The Effect of Water Carbonation on Orthostatic Tolerance · Simon Fraser University
- May 2027Observation of Clinical Routine Care for Patients With BIOTRONIK Implantable Cardiac Monitors (ICMs) · Biotronik SE & Co. KG
- Jun 2027Assesment of the Clinical Benefit of Provocation on Tilt-table in SYNCope Patients, TiltSYNC-trial · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
- Jul 2027REmote Cardiac MOnitoring of At-risk SYNCope Patients After Emergency Department Discharge -RCT · Ottawa Hospital Research Institute
- Sep 2027Canadian Prehospital Syncope Risk Score (Prehospital CSRS) · Venkatesh Thiruganasambandamoorthy
Who these studies take
Of the 26 Syncope studies recruiting now, 17 (65%) set no upper age limit and 4 (15%) stop at 75 or younger. 3 (12%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 3 (12%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (4%) | 1 (4%) |
| 18 | 22 (85%) | 22 (85%) |
| 30 | 23 (88%) | 23 (88%) |
| 40 | 24 (92%) | 24 (92%) |
| 50 | 25 (96%) | 25 (96%) |
| 65 | 24 (92%) | 24 (92%) |
| 75 | 22 (85%) | 22 (85%) |
| 85 | 20 (77%) | 20 (77%) |
Across all 201 studies, recruiting or not: 20% stop at 75 or younger and 19% at 65; 23% take children; <1% are for women only and 1% for men only; 13% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Syncope studies take
Of 48 interventional studies with no phase under Syncope, half reached primary completion within 28 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 28 mo13–52 · 48 studies | — | 39 mo13–52 · 39 studies |
| Observational | 34 mo13–… · 44 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Newly registered2
- Whole-Body Point-of-Care Ultrasound in Older Adults Presenting to the Emergency Department After a FallOct 21, 2026NCT07886164
- Head-to-Head (H2H) Comparison of Ambulatory Cardiac ECG Monitors in JapanOct 13, 2026NCT07870837
Studies
Recruiting first, then most recently updated. Showing 50 of 201. Browse all 201 → or search them.
- Genetic Markers of Cardiovascular Disease in EpilepsyRecruitingNCT028248221 country
- Whole-Body Point-of-Care Ultrasound in Older Adults Presenting to the Emergency Department After a FallRecruitingNCT078861641 country
- Head-to-Head (H2H) Comparison of Ambulatory Cardiac ECG Monitors in JapanNot yet recruitingNCT07870837Not applicable1 country
- Biospecimen Repository for Cardiac Arrhythmias at the Cleveland ClinicRecruitingNCT009219861 country
- Cor360: Clinician-Facing Broad-Spectrum Cardiac Phenotyping and Risk Assessment Using COR® Wearable ECG to Inform Outcomes-Oriented Care PathwaysEnrolling by invitationNCT077759761 country
- AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable MonitorRecruitingNCT066990561 country
- The Effect of Water Carbonation on Orthostatic ToleranceRecruitingNCT05621460Not applicable1 country
- Assesment of the Clinical Benefit of Provocation on Tilt-table in SYNCope Patients, TiltSYNC-trialRecruitingNCT07459478Not applicable1 country
- In Hospital 24 Hour Observation of Syncope PatientsRecruitingNCT064723751 country
- Do QT-Prolonging Drugs Cause Major Adverse Cardiac Events in Hospitalized Adults?RecruitingNCT073742631 country
- REmote Cardiac MOnitoring of At-risk SYNCope Patients After Emergency Department Discharge -RCTRecruitingNCT05066347Not applicable1 country
- Observation of Clinical Routine Care for Patients With BIOTRONIK Implantable Cardiac Monitors (ICMs)RecruitingNCT040750849 countries
- POLish Registry of CArdioneuroablation and CArdioneuromodulationRecruitingNCT071963971 country
- Cardioneuroablation: Fragmented Atrial Potentials, Intracardiac Echocardiography and Computed TomographyRecruitingNCT06472102Not applicable1 country
- Implantable Loop Recorder and CardioneuroblationNot yet recruitingNCT071627401 country
- Canadian Prehospital Syncope Risk Score (Prehospital CSRS)Not yet recruitingNCT055601261 country
- AVEIR™ Leadless Pacemaker (LP) United Kingdom (UK) RegistryRecruitingNCT068544841 country
- Efficacy of a Right-sided Ablation of the Anterior Ganglionated Plexus for Neurally Mediated SyncopeRecruitingNCT04755101Not applicable1 country
- SW-RCT Implementation of Canadian Syncope Risk Score Based Practice RecommendationsRecruitingNCT04972071Not applicable1 country
- Effectiveness of a Wearable Hydration DeviceNot yet recruitingNCT06788795Phase 2
- COR-INSIGHT: Optimizing Cardiovascular and Cardiopulmonary Outcomes with AI-Driven Multiplexed Indications Using COR ECG WearableEnrolling by invitationNCT067635491 country
- Syncope Trial to Understand Tilt Testing or ECG Recording Tenth Prevention of Syncope TrialRecruitingNCT05776810Not applicable1 country
- Acutelines: a Large Data-/Biobank of Acute and Emergency MedicineRecruitingNCT046150651 country
- Remote Symptom Review in Patients With Implantable Diagnostic HolterRecruitingNCT06431828Not applicable1 country
- A Proof of Principle Study of Ondansetron for the Prevention of Vasovagal Syncope: The Eleventh Prevention of Syncope Trial (POST11)RecruitingNCT05755737Phase 21 country
- Study of Ondansetron in the Prevention of Sleep Syncope: The Nineth Prevention of Syncope Trial (POST9)Not yet recruitingNCT05657925Phase 31 country
- The Z Stitch Early Bed Rest Assessment StudyRecruitingNCT06087497Not applicable1 country
- Syncope-Asystole Latency Time in Tilt Table Test: The SALT-TILT StudyRecruitingNCT063562071 country
- Improving Management of Emergency Department Patients With Undifferentiated Syncope: Prospective Validation of the Canadian Syncope Risk ScoreEnrolling by invitationNCT055381431 country
- Cardioneuroablation for BradyarrhythmiaRecruitingNCT06288633Not applicable1 country
- Comparison of the Efficacy and Safety of Cardioneuroablation to Permanent Pacing in Patients With an Implanted Pacemaker for Symptomatic Bradycardia.RecruitingNCT05896592Not applicable1 country
- Essential Hypotension and Allostasis RegistryRecruitingNCT020184971 country
- Cardiac Autonomic Denervation for Cardio-inhibitory SyncopeNot yet recruitingNCT05572034Not applicable1 country
- Mobile Cardiac Outpatient Telemetry for Unexplained SyncopeNot yet recruitingNCT05957315Not applicable
- Global Approach to Faint and FallsRecruitingNCT057526821 country
- Registry of Device ImplantationRecruitingNCT033602271 country
- Creation of a Syncope Channel for Patients Admitted to the Emergency Department for Loss of Consciousness and Not Hospitalized: Etiological Predictivity (Before/After Study)CompletedNCT06503653Not applicable1 country
- Cardioneuroablation for Reflex Syncope and Exercise CapacityActive, not recruitingNCT06440291Not applicable1 country
- High-Sensitivity Troponin T Plasma Levels in Patients With Aortic Stenosis (Tyrolean Aortic Stenosis Study-2)CompletedNCT024484851 country
- Practical Approaches to Care in Emergency SyncopeCompletedNCT045334251 country
- Ambulatory Leadless Electrocardiogram Recorder Trial FeasibilityCompletedNCT058214651 country
- 7-Day MEMO Patch Monitoring for Arrhythmia Detection in Patients With PalpitationsCompletedNCT07728552Not applicable1 country
- A Warning Red Flag Classification System to Predict Risk of Vasovagal Event During Office HysteroscopyActive, not recruitingNCT070302181 country
- Quasi-Randomized Evaluation of the UCLA Next Day Clinic (NDC)CompletedNCT06526884Not applicable1 country
- Assert-IQ Implantable Cardiac Monitor (ICM) Post Market StudyCompletedNCT061726991 country
- Pediatric Adhesion and New Dermal Approach StudyCompletedNCT07118124Not applicable1 country
- Using Mirabegron to Increase BP in Patients With POTSCompletedNCT06133075Phase 21 country
- Arrhythmia Identification in Syncope Patients: ePatch® Versus 24h HolterTerminatedNCT06310707Not applicable2 countries
- ISSUE3: International Study on Syncope of Uncertain Etiology 3CompletedNCT00359203Phase 41 country
- ELIAS: Early Loop-Recorder in Suspected Arrhythmogenic SyncopeCompletedNCT00170261Phase 41 country