Persistent Vegetative State clinical trials
The registry lists 88 studies for Persistent Vegetative State across more than 10 countries. 20 are recruiting or about to start. 28 of them are mainly about Persistent Vegetative State (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-05.
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Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
Hangzhou Normal University (11) · University of Liege (10) · Hospices Civils de Lyon (5) · Xijing Hospital (4) · Hadassah Medical Organization (2) · University of Basel (2) · Casa Colina Hospital and Centers for Healthcare (2) · Hospitales Nisa (2)
What is being tested here
Drugs under test in Persistent Vegetative State studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Apomorphine | 1 | 1 | 3 |
| Amantadine | 0 | 0 | 2 |
| RPH201 | 0 | 0 | 2 |
| Zolpidem | 0 | 0 | 1 |
| Dexmedetomidine | 0 | 0 | 1 |
| Midazolam | 0 | 0 | 1 |
| Phenobarbital | 0 | 0 | 1 |
| Levetiracetam | 0 | 0 | 1 |
| Lacosamide | 0 | 0 | 1 |
| Valproic Acid | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 8, phase 3 first
- Dec 2026Apomorphine in Severe Brain-injured Patients · Phase 3 · University of Liege
- Dec 2026fNIRS for Disorders of Consciousness · University of California, Los Angeles
- Feb 2027Temporal Interference Stimulation for Disorders of Consciousness · Centre Hospitalier Universitaire de Liege
- Apr 2027Neurological and Physiological Effects of Animal-assisted Therapy for Patients in a Minimally Conscious State · University of Basel
- May 2027Multimodal Neuroprognostication in Disorders of Consciousness · Assistance Publique - Hôpitaux de Paris
- Jun 2027AI-Assisted Precision Hyperbaric Oxygen Therapy Based on Dynamic BIS-EEG Feedback for Patients With Disorders of Consciousness · Boston Intelligent Medical Research Center, Shenzhen United Scheme Technology Co., Ltd.
- Nov 2027Auditory Processing in DOC Patients · BDH-Klinik Hessisch Oldendorf
- Nov 2027Assessment of Consciousness With CRS-R and SECONDs · BDH-Klinik Hessisch Oldendorf
Who these studies take
Of the 12 Persistent Vegetative State studies recruiting now, 5 (42%) set no upper age limit and 2 (17%) stop at 75 or younger. 1 (8%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (8%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 12 (100%) | 12 (100%) |
| 30 | 12 (100%) | 12 (100%) |
| 40 | 12 (100%) | 12 (100%) |
| 50 | 12 (100%) | 12 (100%) |
| 65 | 12 (100%) | 12 (100%) |
| 75 | 10 (83%) | 10 (83%) |
| 85 | 6 (50%) | 6 (50%) |
Across all 88 studies, recruiting or not: 34% stop at 75 or younger and 17% at 65; 23% take children; 0% are for women only and 0% for men only; 11% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Persistent Vegetative State studies take
Of 23 interventional studies with no phase under Persistent Vegetative State, half reached primary completion within 35 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 35 mo17–72 · 23 studies | — | — |
| Observational | 36 mo21–60 · 16 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Newly registered2
- Restoring AwarenessNov 5, 2026NCT07918274
- Temporal Interference Stimulation for Disorders of ConsciousnessOct 14, 2026NCT07874178
Studies
Recruiting first, then most recently updated. Showing 50 of 88. Browse all 88 → or search them.
- Restoring AwarenessNot yet recruitingNCT07918274Phase 2
- Temporal Interference Stimulation for Disorders of ConsciousnessNot yet recruitingNCT07874178Not applicable
- AI-Assisted Precision Hyperbaric Oxygen Therapy Based on Dynamic BIS-EEG Feedback for Patients With Disorders of ConsciousnessNot yet recruitingNCT07855848Not applicable1 country
- Prognostication of Recovery in Early Disorders of Consciousness StudyEnrolling by invitationNCT07074678Not applicable1 country
- Multimodal Assessment and Prognosis in Disorders of Consciousness After Severe Brain Injury (CyDoC-MAP)Not yet recruitingNCT077368201 country
- Promoting Recovery After Brain Injury Using Focused UltrasoundRecruitingNCT07277309Not applicable1 country
- fNIRS for Disorders of ConsciousnessRecruitingNCT074853611 country
- mindBEAGLE: Unlocking Functional Communication for Patients With Disorders of ConsciousnessEnrolling by invitationNCT06426602Not applicable1 country
- Neurorehabilitation in Patients With Disorders of Consciousness: Multidimensional Ambispective Study on the Impact of Single and Combined ApproachesRecruitingNCT073855081 country
- Ultrasound Stimulation for Patients in a Disorder of ConsciousnessRecruitingNCT06939348Not applicable1 country
- Effectiveness of tTIs for Improving Consciousness in Patients With DoCRecruitingNCT07539740Not applicable1 country
- Assessment of Consciousness With CRS-R and SECONDsRecruitingNCT074560201 country
- Auditory Processing in DOC PatientsNot yet recruitingNCT074556821 country
- Neurological and Physiological Effects of Animal-assisted Therapy for Patients in a Minimally Conscious StateRecruitingNCT06931665Not applicable1 country
- Measuring Brain Complexity to Detect and Predict Recovery of Consciousness in the ICURecruitingNCT06568536Not applicable1 country
- Apomorphine in Severe Brain-injured PatientsRecruitingNCT05213169Phase 2/32 countries
- Transcranial Temporal Interference Stimulation In Severely Brain Injured Patients With Disorders of ConsciousnessRecruitingNCT06851156Not applicable1 country
- Characterization of the Sleep-Wake Cycle in Traumatic Brain Injury Patients with a Disorder of ConsciousnessNot yet recruitingNCT06766513Not applicable1 country
- Multimodal Neuroprognostication in Disorders of ConsciousnessRecruitingNCT045347771 country
- CONNECT-ME: Consciousness in Neurocritical Care Cohort Study Using fMRI and EEGRecruitingNCT026442651 country
- Study of Conscious Behavior Under Low-frequency Deep Brain Stimulation in Chronic and Severe Post-coma Disorders of ConsciousnessCompletedNCT01718249Not applicable1 country
- Window On the BrainCompletedNCT06693492Not applicable1 country
- Closed-loop tDCS in Patients in Minimally Conscious StateCompletedNCT03810079Not applicable1 country
- Transcutaneous Auricular Vagal Nerve Stimulation for Post-coma Patients With Disorders of ConsciousnessCompletedNCT04065386Not applicable1 country
- Longitudinal Study of the Default-mode Network Connectivity in Brain Injured Patients Recovering From ComaCompletedNCT016209571 country
- Antiseizure Medication in Seizure Networks at Early Acute Brain InjuryTerminatedNCT06081283Phase 41 country
- Beneficial Effects of Music on Cognition and Consciousness LevelCompletedNCT02742506Not applicable1 country
- Therapeutic Effects of Animal-assisted Therapy for Patients in a Minimally Conscious StateCompletedNCT03910959Not applicable1 country
- Emotion Assessment to Study Consciousness in Awakening PatientsCompletedNCT03706170Not applicable1 country
- Excitatory Prefrontal Weak Current Stimulation in Vegetative PatientsCompletedNCT04614792Not applicable1 country
- Survival and Predictive Factors of Clinical Outcome in Patients With Acquired Brain InjuryCompletedNCT059689111 country
- Eye Tracking Technology in the Diagnosis of Neurological PatientsCompletedNCT055369211 country
- Clinical Validity of the Minimally Conscious State "Plus" and "Minus"CompletedNCT059546501 country
- The Use of LIFUP in Chronic Disorders of ConsciousnessCompletedNCT04921683Not applicable1 country
- Vagus Nerve Stimulation to Augment Recovery From Minimally Conscious or Persistently Vegetative States After Traumatic Brain InjuryWithdrawnNCT01260090Phase 2/31 country
- Information of the Coma Recovery Scale-Revised for Neurobehavioral State and Recovery of Consciousness PredictionCompletedNCT058191771 country
- Development of a Point of Care System for Automated Coma PrognosisStatus unknownNCT038264071 country
- Cerebellar iTBS in Patients With Disorders of ConsciousnessStatus unknownNCT05558930Not applicable1 country
- Brain Network Characteristics in Patients With Disorders of ConsciousnessStatus unknownNCT055586701 country
- Detection of Arousal With Facial Micro-expression in Severe Brain-damaged PatientTerminatedNCT03023657Not applicable1 country
- Chinese Validation of the Simplified Evaluation of CONsciousness Disorders(SECONDs)CompletedNCT05496985Not applicable1 country
- The Prognostic Value of Pupil Near Response in UWS PatientsCompletedNCT02832492
- Validation of the Chinese Version of the SECONDsCompletedNCT04687553Not applicable1 country
- Simultaneously PET/MRI in Prolonged DOC PatientsCompletedNCT041646801 country
- A Promising Tool for Predicting Consciousness Evolution in Prolonged Disorders of ConsciousnessCompletedNCT02948660Phase 21 country
- Treating Severe Brain-injured Patients With ApomorphineStatus unknownNCT03623828Phase 21 country
- Neural, Behavioural, and Clinical Effects of tDCS in PDOC; Feasibility StudyStatus unknownNCT04248946Not applicable1 country
- Use of Analgesic Treatment to Reduce Signs of Pain in Patients With Disorders of Consciousness.CompletedNCT04330547Phase 11 country
- Aiming for a Better Understanding and Improvement of the Diagnosis and Prognosis of Patients With Disorders of Consciousness Through Multimodal ObservationsStatus unknownNCT047984564 countries
- The Effects of Olfactory Stimulation on Diagnosis and Prognosis of DOC PatientsCompletedNCT037320921 country