Drug
Phentolamine clinical trials
Also written OraVerse.
- studies test it
- 38
- open now
- 10
- in phase 3
- 13
- first study started
- 2001
Keep track of what changes. Save the Phentolamine studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
38 studies that test it; most in 2024 (5)
| Year | Studies |
|---|---|
| 2001 | 1 |
| 2003 | 1 |
| 2005 | 1 |
| 2006 | 3 |
| 2007 | 1 |
| 2008 | 1 |
| 2011 | 1 |
| 2012 | 1 |
| 2015 | 1 |
| 2016 | 1 |
| 2017 | 4 |
| 2019 | 2 |
| 2020 | 2 |
| 2021 | 3 |
| 2022 | 3 |
| 2023 | 2 |
| 2024 | 5 |
| 2025 | 5 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 4
- Phase 1
- 3
- Phase 2
- 9
- Phase 3
- 13
- Phase 4
- 3
- No phase
- 7
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 18 · Other 20
Ocuphire Pharma, Inc. (11) · Novalar Pharmaceuticals, Inc. (4) · Opus Genetics, Inc (2) · Radboud University Medical Center (2) · University of Alberta (2) · Dalhousie University (2) · University of Missouri-Columbia (2) · Vanderbilt University Medical Center (1)
Often tested with
Tested in the same studies.
Propranolol (6) · Norepinephrine (4) · Phenylephrine (3) · Pilocarpine (2) · Nitroprusside (2) · Isoproterenol (2) · Alprostadil (1) · Papaverine (1)
Studies
Open first, then newest update. How each study uses Phentolamine is read from its arms, and is right about nine times in ten.
Testing it · 38
- OPI-NXYDLD-303 Safety and Efficacy of Phentolamine Ophthalmic Solution in Keratorefractive Surgery Participants With Decreased Mesopic Visual AcuityRecruitingPhase 3Opus Genetics, IncNCT07140783Written as 0.75% Phentolamine Ophthalmic Solution
- : Vascular Function in Health and DiseaseRecruitingPhase 1D. Walter WrayNCT02966665Written as Acetylcholine, Sodium Nitroprusside, Angiotensin-II, Norepinephrine, Phentolamine
- Sex Disparities in Hypoxic Vasodilation and Impact of ObesityRecruitingEarly Phase 1University of Missouri-ColumbiaNCT05219799Written as Phentolamine Mesylate
- Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex DifferencesRecruitingPhase 4University of AlbertaNCT05997732Written as Phentolamine Mesylate
- Sympathetic Vascular Transduction Across the Menopause Transition: Contributing MechanismsRecruitingEarly Phase 1University of Missouri-ColumbiaNCT06787066Written as Phentolamine Injection
- Effectiveness of Phentolamine Mesylate as a Reversing Agent for Local Anesthesia in ChildrenRecruitingPhase 3Cairo UniversityNCT05448807Written as OraVerse
- Pre-operative Phentolamine Vs Intraoperative Esmolol Efficacy for Hypotensive Anesthesia in Functional Endoscopic Sinus SurgeryNot yet recruitingNot applicableAin Shams UniversityNCT06620991Written as Phentolamine
- Intravenous Labetalol vs Phentolamine for the Management of Severe Preeclampsia.Not yet recruitingNot applicableAssiut UniversityNCT06385600Written as Phentolamine
- Efficacy of Phentolamine in Prevention of Contrast-Associated Acute Kidney Injury After Complex PCIRecruitingPhase 2/3Helwan UniversityNCT06286059Written as Phentolamine
- New Perspective on Exploring the Post-apneic BP Surge in Patients With OSARecruitingEarly Phase 1Xu JNCT06172998Written as Phentolamine Injection
- Phentolamine Mesylate vs. Diode Laser for Anaesthesia ReversalCompletedPhase 3sara nabilNCT05473858Written as OraVerse Injectable Product
- The Safety and Efficacy of Phentolamine Mesylate Ophthalmic Solution in Subjects With Severe Night Vision DisturbancesCompletedPhase 2Opus Genetics, IncNCT01703559Written as Phentolamine Mesylate Ophthalmic Solution 1.0%
- Safety and Efficacy of 0.75% Phentolamine Ophthalmic Solution in Subjects With Post-refractive Surgery Visual DisturbancesCompletedPhase 3Ocuphire Pharma, Inc.NCT06349759Written as phentolamine ophthalmic solution 0.75%, a non-selective alpha-1 and alpha-2 adrenergic antagonist
- Evaluate Efficacy and Safety of POS to Improve Distance-corrected Near Visual in Participants With PresbyopiaCompletedPhase 3Ocuphire Pharma, Inc.NCT06542497Written as 0.75% phentolamine ophthalmic solution
- The Role of the Adrenergic System in Hypoglycaemia Induced Inflammatory Response in People With Type 1 Diabetes and People Without Type 1 Diabetes-RAID-IICompletedNot applicableRadboud University Medical CenterNCT06422494Written as Phentolamine
- Safety and Efficacy of Nyxol Eye Drops as a Single Agent and With Adjunctive Low-Dose Pilocarpine Eye Drops in Subjects With PresbyopiaCompletedPhase 3Ocuphire Pharma, Inc.NCT05646719Written as Phentolamine Opthalmic Solution 0.75%
- Adrenergic System in Islet TransplantationCompletedEarly Phase 1University of PennsylvaniaNCT03079921Written as Phentolamine
- Role of Sympathetic Vasoconstriction on Insulin-Mediated Microvascular Recruitment and Glucose Uptake in ObesityActive, not recruitingPhase 1Vanderbilt University Medical CenterNCT03318094Written as Phentolamine
- Safety and Efficacy of Nyxol (0.75% Phentolamine Ophthalmic Solution) in Subjects With Dim Light Vision DisturbancesCompletedPhase 3Ocuphire Pharma, Inc.NCT04638660Written as Phentolamine Ophthalmic Solution 0.75%
- Safety and Efficacy of Nyxol With Pilocarpine Eye Drops in Subjects With PresbyopiaCompletedPhase 2Ocuphire Pharma, Inc.NCT04675151Written as Phentolamine Ophthalmic Solution 0.75%
Codes
What other systems call Phentolamine · ClinicalTrials.gg INT007999
- MeSH (NLM) D010646PhentolamineConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) Z468598HBVPHENTOLAMINEConfirmed FDA, NLM, Wikidata
- RxNorm 8153Confirmed FDA, Wikidata
- Wikidata Q420360phentolamineConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C62066PhentolamineOne source FDA
- DrugBank DB00692One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D010646 | Phentolamine | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | Z468598HBV | PHENTOLAMINE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 8153 | — | Confirmed FDA, Wikidata |
| Wikidata | Q420360 | phentolamine | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C62066 | Phentolamine | One source FDA |
| DrugBank | DB00692 | — | One source Wikidata |
Also registered as phentolamine mesylate (UNII Y7543E5K9T · RxNorm 227240).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.