Drug
Pilocarpine clinical trials
Also written AGN-190584, Salagen and VUITY.
- studies test it
- 38
- open now
- 5
- in phase 3
- 13
- first study started
- 1998
Keep track of what changes. Save the Pilocarpine studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Brand
Development codes
Other names
Combined with it in one product
Studies by the year they started
38 studies that test it; most in 2019 (5)
| Year | Studies |
|---|---|
| 1998 | 2 |
| 2002 | 1 |
| 2003 | 2 |
| 2004 | 2 |
| 2005 | 1 |
| 2006 | 1 |
| 2009 | 2 |
| 2011 | 1 |
| 2015 | 2 |
| 2016 | 4 |
| 2018 | 2 |
| 2019 | 5 |
| 2020 | 1 |
| 2021 | 3 |
| 2022 | 4 |
| 2023 | 1 |
| 2024 | 2 |
| 2025 | 2 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 3
- Phase 1
- 5
- Phase 2
- 1
- Phase 3
- 13
- Phase 4
- 3
- No phase
- 13
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 13 · Other 25
Roxane Laboratories (4) · Allergan (3) · Ocuphire Pharma, Inc. (2) · Optall Vision (2) · Maastricht University Medical Center (2) · Astellas Pharma Europe B.V. (2) · Montefiore Medical Center (2) · Al-Azhar University (1)
Often tested with
Tested in the same studies.
Phentolamine (2) · Brimonidine (2) · Lubricant Eye Drops (1) · Tropicamide (1) · Proxymetacaine (1) · Cevimeline (1) · Ibuprofen (1) · ASP6282 (1)
Studies
Open first, then newest update. How each study uses Pilocarpine is read from its arms, and is right about nine times in ten.
Testing it · 38
- Pilocarpine Use After Kahook GoniotomyRecruitingPhase 3Montefiore Medical CenterNCT03933631Written as Pilocarpine
- Quality of Life in Presbyopic Patients Who Are Treated With QlosiRecruitingPhase 4Southern College of OptometryNCT07113210Written as pilocarpine HCL ophthalmic solution
- Adjusted Study Protocol: Within-Subject Paired-Eye Design Comparing Pilocarpine 0.1%, Phentolamine 0.75%, and Combination Therapy for Cyclopentolate Reversal in ChildrenNot yet recruitingNot applicableMansoura UniversityNCT07012512Written as Pilocarpine 0.1%
- Safety and Efficacy Study of Pilocarpine HCl Ophthalmic Solution in Participants With PresbyopiaNot yet recruitingPhase 3CSPC Ouyi Pharmaceutical Co., Ltd.NCT06451666Written as Pilocarpine HCl Ophthalmic Solution
- Xerostomia in Patients With a Life-limiting Condition or FrailtyNot yet recruitingPhase 3Maastricht University Medical CenterNCT05506137Written as Pilocarpine
- Safety and Efficacy of Nyxol Eye Drops as a Single Agent and With Adjunctive Low-Dose Pilocarpine Eye Drops in Subjects With PresbyopiaCompletedPhase 3Ocuphire Pharma, Inc.NCT05646719Written as Low dose pilocarpine
- Safety and Efficacy of Nyxol With Pilocarpine Eye Drops in Subjects With PresbyopiaCompletedPhase 2Ocuphire Pharma, Inc.NCT04675151Written as Pilocarpine
- Efficacy of Pilocarpine As a Secretagogue Versus Artificial Tears for the Treatment of Dry EyeCompletedNot applicableAl-Azhar UniversityNCT06752278Written as Pilocarpine
- A Study to Assess Safety and Efficacy in Participants Age 40 to 55 With Presbyopia (Old Eye) Who Receive AGN-190584 in Both Eyes Twice DailyCompletedPhase 3AllerganNCT04983589Written as Pilocarpine HCl
- Wearing-Off Period of Pharmacological Dilation and AnisocoriaCompletedPhase 4Prisma Health-UpstateNCT05238233Written as 1% Pilocarpine
- Pharmacological Treatment of PresbyopiaStatus unknownEarly Phase 1Shahid Beheshti University of Medical SciencesNCT05564832Written as Pilocarpine 1.25% Eye drop
- Morphological Changes of Ciliary Body and Trabecular MeshworkStatus unknownNot applicableYune ZhaoNCT05352854Written as 0.5% pilocarpine eye drops
- Anterior Segment Imaging With Ultrahigh-resolution OCT in Patients With Glaucoma and PEX - a Pilot StudyStatus unknownNot applicableMedical University of ViennaNCT02865473Written as Pilocarpine
- Pilocarpine After Combined Cataract/Trabectome SurgeryWithdrawnPhase 3Montefiore Medical CenterNCT04005079Written as Pilocarpine
- A Phase 3 Efficacy Study of Pilocarpine HCl Ophthalmic Solution (AGN-190584) in Participants With PresbyopiaCompletedPhase 3AllerganNCT03857542Written as Pilocarpine HCl Ophthalmic Solution
- Efficacy Study of Pilocarpine HCl Ophthalmic Solution (AGN-190584) in Participants With PresbyopiaCompletedPhase 3AllerganNCT03804268Written as Pilocarpine HCl Ophthalmic Solution
- Compound to Control Presbyopia SymptomsCompletedPhase 1Optall VisionNCT05006898Written as PBO to control presbyopia symptoms
- Comparison of a Compound With Pilocarpine and Brimonidine to Improve Near Vision in Healthy Presbyopic PatientsStatus unknownPhase 1Optall VisionNCT05001243Written as Pilocarpine Hydrochloride
- Oral Pilocarpine in the Treatment of the Dry Eye of Patients With Sjogrens SyndromeCompletedPhase 3Federal University of São PauloNCT04470479Written as Pilocarpine Hydrochloride
- Measuring Sweat Glucose of Patients With Diabetes - The ENGAGE StudyTerminatedNot applicableUniversity of California, San DiegoNCT03460964Written as Pilocarpine
See all 38 studies that test Pilocarpine →
Given in every arm · 2 — Pilocarpine is usual care beside what is tested
- (Study: Vertex IIS) Does Ivacaftor Alter Wild Type CFTR-Open Probability In The Sweat Gland Secretory Coil?CompletedNot applicableRichard Barry MossNCT02310789Written as Pilocarpine Nitrate 5%
- Laser Peripheral Iridotomy Plus Laser Peripheral Iridoplasty for Primary Angle ClosureStatus unknownNot applicableSun Yat-sen UniversityNCT02613013Written as Pilocarpine
As the comparator · 3 — what is tested is compared with Pilocarpine
- Evaluation of NV701 (Pilocarpine 1.25%) Compared With Vuity (Pilocarpine 1.25%) on Pupil Size in Subjects With PresbyopiaCompletedEarly Phase 1Novus Vision LLCNCT06783686Written as Pilocarpine 1.25% Eye drop
- Travoprost 0.004% Versus Pilocarpine 1% in Patients With Chronic Angle Closure Glaucoma (CACG)CompletedPhase 4Alcon ResearchNCT00762645Written as Pilocarpine 1%
- Acupuncture-Like Transcutaneous Electrical Nerve Stimulation (ALTENS) or Pilocarpine in Treating Early Dry Mouth in Patients Undergoing Radiation Therapy for Head and Neck CancerCompletedPhase 2/3Radiation Therapy Oncology GroupNCT00656513Written as Pilocarpine
Codes
What other systems call Pilocarpine · ClinicalTrials.gg INT008021
- MeSH (NLM) D010862PilocarpineConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 01MI4Q9DI3PILOCARPINEConfirmed FDA, NLM, Wikidata
- RxNorm 8328Confirmed FDA, Wikidata
- Wikidata Q411461pilocarpineConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C62068PilocarpineOne source FDA
- DrugBank DB01085One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D010862 | Pilocarpine | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 01MI4Q9DI3 | PILOCARPINE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 8328 | — | Confirmed FDA, Wikidata |
| Wikidata | Q411461 | pilocarpine | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C62068 | Pilocarpine | One source FDA |
| DrugBank | DB01085 | — | One source Wikidata |
Also registered as pilocarpine hydrochloride (UNII 0WW6D218XJ · RxNorm 235426) and pilocarpine nitrate (UNII M20T465H6J · RxNorm 103244).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.