Diabetes Mellitus, Type 1 clinical trials
The registry lists 3,754 studies for Diabetes Mellitus, Type 1 across more than 10 countries. 600 are recruiting or about to start. 3,345 of them are mainly about Diabetes Mellitus, Type 1 (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-13.
ClinicalTrials.gov finds 4,671 studies for Diabetes Mellitus, Type 1. How that becomes 3,751 here
This page counts the studies the registry files under Diabetes Mellitus, Type 1, and those it files under no condition that list Diabetes Mellitus, Type 1themselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 4,671Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −69List Diabetes Mellitus, Type 1 as a condition, but the registry did not file them under itMost often written as “Type1diabetes” (27), “Diabete Type 1” (9), and “Type1 Diabetes Mellitus” (8). The registry filed them under other conditions only, most often Diabetes Mellitus (22) and Hypoglycemia (14).
- −889Match it another way157 name it in the title, 5 in a keyword, and 727 by a synonym or other text the search reads.
- 3,713Counted here and found by its search142 of them list Diabetes Mellitus, Type 1 in their own words; the registry filed them under no condition.
- +38
Counted here, but its search does not find them
- Interleukin-2 Therapy of Autoimmunity in Diabetes (ITAD)NCT03782636
- A Trial of Diabetes-educated Psychologist to Improve HbA1c and Reduce Diabetes-related DistressNCT03753997
- Bridging the Gap to Adult Diabetes CareNCT03781973
- Mechanisms for Restoration of Hypoglycemia AwarenessNCT03738852
- Safe Use of New Technologies in Diabetes in FlightNCT06408558
- A Evaluation of Systematic Intensive Therapy Using CGM/FGM in Clinical Diabetes CareNCT03474393
- Search for a Link Between the Different Variables for Glycaemia and Oxidative Stress or Impaired HDL FunctionNCT02862860
- Diluted Insulin in Young Children: Bigger Volumes for Smaller PatientsNCT03666065
- Specialized Technology Education for Pumps & Pens in Underserved Populations With DiabetesNCT04550585
- A Pilot Test of t:Slim X2 With Control-IQ TechnologyNCT03368937
- Unannounced Meal Handling of Advanced Closed Loop Insulin Delivery in Monitored ConditionNCT04479826
- Physical Exercise in Normobaric Hypoxia and Normoxia in Type 1 Diabetic PatientsNCT04450745
- Real-time Reminders To Decrease Late or Missed Meal BolusesNCT03970889
- A Study of LY900014 in a Medtronic PumpNCT03760640
- Safety and Efficacy of 7-day Wear Infusion Set vs. Control Infusion Set.NCT04208282
- Comparative Study Between Two Models of a Non-invasive Glucose Monitoring DeviceNCT03530644
- Adolescence and Diabetes:Can an Automated Closed Loop System Improve Control ?NCT03300934
- The Monitoring StudyNCT02969863
- A Trial to Evaluate the Pharmacokinetic and Pharmacodynamic Properties of BioChaperone® Insulin Lispro, Fiasp® and NovoRapid® Delivered by an Insulin PumpNCT03179332
- Comparison of Closed-loop Operation After Morning Meal With and Without Carbohydrate CountingNCT01519102
- 3,751The count on this page
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Status
Who runs them
Novo Nordisk A/S (225) · Eli Lilly and Company (74) · University of Virginia (73) · Sanofi (64) · University of Colorado, Denver (58) · Yale University (50) · Medtronic Diabetes (48) · Steno Diabetes Center Copenhagen (47)
What is being tested here
Drugs under test in Diabetes Mellitus, Type 1 studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Semaglutide | 11 | 8 | 16 |
| Sotagliflozin | 6 | 5 | 14 |
| Verapamil | 5 | 2 | 8 |
| Tirzepatide | 5 | 4 | 7 |
| Insulin | 4 | 8 | 51 |
| Insulin Lispro | 3 | 14 | 65 |
| Insulin Aspart | 2 | 26 | 85 |
| Liraglutide | 2 | 12 | 32 |
| Dapagliflozin | 2 | 8 | 21 |
| Metformin | 2 | 9 | 21 |
Drug classes tested here GLP-1 receptor agonists 19 open · SGLT2 inhibitors 9 open · Calcium channel blockers 5 open · Tyrosine kinase inhibitors (TKIs) 4 open · JAK inhibitors 3 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Nov 2026A Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obesity or Overweight · Phase 3 · Eli Lilly and Company
- Nov 2026A Long-Term Study of Tirzepatide (LY3298176) in Adults With Type 1 Diabetes and Obesity or Overweight · Phase 3 · Eli Lilly and Company
- Jan 2027A Clinical Trial to Evaluate The Effects of Semaglutide and Empagliflozin Combined to Automated Insulin Delivery on Diabetes Control in Adults Living With Type 1 Diabetes · Phase 3 · McGill University Health Centre/Research Institute of the McGill University Health Centre
- Jan 2027Alleviating Carbohydrate Counting for Patients with Type-1 Diabetes Using a Closed Loop System with Weekly Subcutaneous Semaglutide · Phase 3 · McGill University Health Centre/Research Institute of the McGill University Health Centre
- Jan 2027A Research Study to See How a Weekly Insulin, Insulin Icodec, Helps in Reducing the Blood Sugar Compared to Daily Insulin Glargine, Both in Combination With Insulin Aspart, in Adults With Type 1 Diabetes · Phase 3 · Novo Nordisk A/S
- Feb 2027Oral Verapamil Among Newly Diagnosed Children and Adolescents With Type 1 Diabetes · Phase 3 · Ain Shams University
- Apr 2027Cadisegliatin as Adjunctive Therapy to Insulin in Participants With Type 1 Diabetes · Phase 3 · vTv Therapeutics
- Jun 2027SGLT2i, Pioglitazone, and Ketone Production in T1D · Phase 3 · The University of Texas Health Science Center at San Antonio
- Sep 2027Impact of Metformin on Peripheral Arterial Calcification in Type 1 Diabetes · Phase 3 · Assistance Publique - Hôpitaux de Paris
- Oct 2027Type 1 Diabetes Impacts of Semaglutide on Cardiovascular Outcomes · Phase 3 · University of Colorado, Denver
Who these studies take
Of the 412 Diabetes Mellitus, Type 1 studies recruiting now, 128 (31%) set no upper age limit and 258 (63%) stop at 75 or younger. 185 (45%) take children under 18. 14 (3%) are for women only and 3 (1%) for men only; 64 (16%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 137 (33%) | 137 (33%) |
| 18 | 339 (82%) | 331 (80%) |
| 30 | 289 (70%) | 281 (68%) |
| 40 | 278 (67%) | 270 (66%) |
| 50 | 258 (63%) | 251 (61%) |
| 65 | 227 (55%) | 219 (53%) |
| 75 | 177 (43%) | 169 (41%) |
| 85 | 146 (35%) | 140 (34%) |
Across all 3,754 studies, recruiting or not: 67% stop at 75 or younger and 57% at 65; 40% take children; 2% are for women only and 2% for men only; 15% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Diabetes Mellitus, Type 1 studies take
Of 153 phase 1 interventional studies under Diabetes Mellitus, Type 1, half reached primary completion within 12 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 12 mo5–32 · 153 studies | 7 mo4–13 · 98 studies | 37 mo18–64 · 55 studies |
| Phase 1/2 | 57 mo31–93 · 44 studies | — | — |
| Phase 2 | 36 mo17–63 · 133 studies | 19 mo7–33 · 50 studies | 51 mo31–76 · 83 studies |
| Phase 2/3 | 23 mo12–41 · 19 studies | — | — |
| Phase 3 | 18 mo10–31 · 106 studies | 17 mo9–25 · 78 studies | — |
| Phase 4 | 22 mo12–38 · 74 studies | — | 25 mo13–46 · 62 studies |
| Interventional, no phase | 18 mo9–35 · 950 studies | 10 mo5–18 · 105 studies | 19 mo10–38 · 845 studies |
| Observational | 30 mo12–69 · 299 studies | 22 mo12–42 · 50 studies | 30 mo12–78 · 249 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 14, 2026.
Started recruiting5
- Can Mindfulness and Virtual Reality Reduce Stress in Young Adults With Type 1 Diabetes?Nov 12, 2026NCT07793097
- Cadisegliatin as Adjunctive Therapy to Insulin in Participants With Type 1 Diabetes Who Are Using Hybrid Closed Loop (HCL) SystemsNov 10, 2026NCT07616206
- Estimated Risk of Preeclampsia in the First Trimester and Its Association With Subclinical Atherosclerosis and Cardiovascular Risk in Women With Type 1 DiabetesNov 5, 2026NCT07479329
- Cardiometabolic Effects of Non-Nutritive Sweeteners (NNS) in Type 1 Diabetes (T1D)Oct 20, 2026NCT07434544
- The Impact of Early Automated Insulin Delivery (AID) Therapy on Diabetes Control and Comorbidities, and Cost-effectiveness of AID TreatmentOct 14, 2026NCT07423637
Results posted8
- T1D-CATCH Protocol: Collaboration Around Technology Using Community Health Workers for Young Adults With Type 1 DiabetesNov 12, 2026NCT05211869
- A Pilot Study of Fenofibrate to Prevent Kidney Function Loss in Type 1 DiabetesNov 10, 2026NCT04929379
- A Study of CT-868 in Type 1 Diabetes MellitusOct 28, 2026NCT06062069
- A Study to Learn How Well the Study Treatment Finerenone Works and How Safe it is in People With Long-term Decrease in the Kidneys' Ability to Work Properly (Chronic Kidney Disease) Together With Type 1 DiabetesOct 27, 2026NCT05901831
- Cardiovascular Risk Stratification in Young People With Type 1 DiabetesOct 22, 2026NCT05283538
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- Research on Optimizing the Use of Technology With EducationOct 22, 2026NCT05564481
- Reduction of Nocturnal Hypoglycemia and Hyperglycemia in the Home Using Predictive Algorithms, Pump Suspension, and Insulin Dosing in Children and Young AdolescentsOct 15, 2026NCT02714972
- Day and Night Closed-loop in Young People With Type 1 DiabetesOct 15, 2026NCT02925299
Stopped2
- Incretin Hormones in Type 1 Diabetes Mellitus;Effect of Metformin TreatmentWithdrawnNov 3, 2026NCT04177303
- Premixed Glucagon/Insulin Solution for Faster Insulin Absorption in Type 1 DiabetesTerminatedOct 19, 2026NCT06854861
Newly registered14
- Immunological Signatures of MASLD and MASH in Patients With Type 1 DiabetesNov 10, 2026NCT07927647
- Efficacy, Safety and Cardiovascular Protection of Mazdutide in Type 1 DiabetesNov 9, 2026NCT07924553
- Inter-Arm Differences in Continuous Glucose Monitor Readings in Adults With DiabetesNov 5, 2026NCT07920341
- Outpatient Pramlintide StudyNov 3, 2026NCT07914621
- Differentiating Heart Disease Between Adult-onset Autoimmune and Type 2 DiabetesNov 2, 2026NCT07911007
Show 9 moreShow fewer
- Relationship Between Insulin Dose and Complications in Type 1 DiabetesNov 2, 2026NCT07911033
- Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PAL-119 in Healthy Volunteers and Adult Participants With Type 1 or Type 2 DiabetesOct 28, 2026NCT07901595
- Lean Mass Changes With Semaglutide in Adults With Type 1 Diabetes and Overweight/Obesity.Oct 23, 2026NCT07891156
- MENA/Levant Epidemiological, Registry of Immunological & Clinical Traits (MERIT)Oct 23, 2026NCT07892651
- RIGHTEST iFree 2 CGM in Pregnant Women With Diabetes StudyOct 22, 2026NCT07889388
- A Phase 2 Two-Part Study of Oral PS1 in Healthy Volunteers and Adults With Newly Diagnosed Type 1 DiabetesOct 22, 2026NCT07889505
- Comprehensive Intervention to Promote Adjustment in Adolescents With Type 1 Diabetes and Their Parents During Transfer of Health Care ResponsibilityOct 21, 2026NCT07886307
- Verapamil In Preclinical Type 1 DiabetesOct 19, 2026NCT07880769
- Pancreas Transplant Alone in Uremia and Non-uremia PatientsOct 14, 2026NCT07872800
Studies
Recruiting first, then most recently updated. Showing 50 of 3,754. Browse all 3,754 → or search them.
- Evaluation of MiniMed Next Generation Extended Wear Sensors and Algorithm in Patients With Type 1 and Type 2 DiabetesRecruitingNCT07864168Not applicable1 country
- A Study to Investigate Efficacy and Safety of Teplizumab Compared With Placebo in Participants 1 to 25 Years of Age With Stage 3 Type 1 DiabetesRecruitingNCT07088068Phase 320 countries
- Food Insecurity Reduction & Strategy TeamRecruitingNCT06329375Not applicable1 country
- Gastric Pathophysiology in DiabetesRecruitingNCT060681142 countries
- Thrive With Type 1 Diabetes 2026RecruitingNCT07522866Not applicable1 country
- CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Within 6 Months) Stage 3 Type 1 Diabetes (T1D)RecruitingNCT06783309Phase 1/21 country
- Outpatient Pramlintide StudyNot yet recruitingNCT07914621Not applicable
- Can Mindfulness and Virtual Reality Reduce Stress in Young Adults With Type 1 Diabetes?RecruitingNCT07793097Not applicable1 country
- To Study the Efficacy and Safety of Medtronic 780G Insulin Pump in People With Gastroparesis and Type 1 Diabetes.RecruitingNCT07287943Not applicable1 country
- Cadisegliatin as Adjunctive Therapy to Insulin in Participants With Type 1 Diabetes Who Are Using Hybrid Closed Loop (HCL) SystemsRecruitingNCT07616206Phase 21 country
- Immunological Signatures of MASLD and MASH in Patients With Type 1 DiabetesNot yet recruitingNCT079276471 country
- SMARTCLOTH. Design, Implementation and Study of the Effectiveness and Usability of a Digital Tablecloth for Self-management of Diet in Diabetic Patients.Enrolling by invitationNCT06623708Not applicable1 country
- Impact of Dietary Fat and Menstrual Cycle Phases in Type 1 DiabetesNot yet recruitingNCT07278063Not applicable1 country
- Long-Term Outcomes of Teplizumab in Routine Clinical CareRecruitingNCT073600804 countries
- Efficacy, Safety and Cardiovascular Protection of Mazdutide in Type 1 DiabetesNot yet recruitingNCT07924553Not applicable
- Prevalence and Factors Associated With Depression Among Children and Adolescents With Type 1 Diabetes MellitussNot yet recruitingNCT07925164
- Permissive Versus Strict Intrapartum Glucose Management in Type 1 and Type 2 Diabetes (PRISM)RecruitingNCT07293715Phase 41 country
- Real-World Study of Patients With Type 1 Diabetes Treated With Teplizumab as Part of Managed Access Programs (MAPs)RecruitingNCT074575806 countries
- Inter-Arm Differences in Continuous Glucose Monitor Readings in Adults With DiabetesNot yet recruitingNCT07920341Not applicable1 country
- Estimated Risk of Preeclampsia in the First Trimester and Its Association With Subclinical Atherosclerosis and Cardiovascular Risk in Women With Type 1 DiabetesRecruitingNCT074793291 country
- A Study of Baricitinib (LY3009104) for the Delay of Stage 3 Type 1 Diabetes in At-Risk Children and AdultsRecruitingNCT07222137Phase 319 countries
- A Study of Baricitinib (LY3009104) to Preserve Beta Cell Function in Children and Adults Newly Diagnosed With Type 1 Diabetes (BARICADE-PRESERVE)RecruitingNCT07222332Phase 320 countries
- CKM For Safe Use of SGLT2i in Type 1 DiabetesNot yet recruitingNCT07211802Phase 31 country
- C-Carbs: A CGM-guided Approach to Teaching Carb AwarenessRecruitingNCT07807280Not applicable1 country
- Differentiating Heart Disease Between Adult-onset Autoimmune and Type 2 DiabetesRecruitingNCT07911007Not applicable1 country
- RIGHTEST iFree 2 CGM in Pregnant Women With Diabetes StudyRecruitingNCT07889388Not applicable1 country
- Relationship Between Insulin Dose and Complications in Type 1 DiabetesNot yet recruitingNCT079110331 country
- Supporting Medtronic 780G Insulin Pump Adoption in Latino Patients: A Spanish - Language Training InitiativeRecruitingNCT07720388Not applicable1 country
- Study of High Density Lipoprotein Function in Type 1 Diabetic Patients With NephropathyRecruitingNCT035121321 country
- Closed Loop and Education for Hypoglycemia Awareness RestorationRecruitingNCT06325202Not applicable3 countries
- Starting Technology in At Risk Type 1 Diabetes StudyRecruitingNCT06453928Not applicable1 country
- Cholesterol Lowering and Residual Risk in Diabetes, Type 1RecruitingNCT05641753Phase 41 country
- INfluenza VaccInation To Mitigate typE 1 DiabetesRecruitingNCT05585983Phase 41 country
- Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PAL-119 in Healthy Volunteers and Adult Participants With Type 1 or Type 2 DiabetesNot yet recruitingNCT07901595Phase 1/2
- Crosstalk Between Mucosal-Associated Invariant T (MAIT) Cells and the Gut Microbiota and Mucosa in the Development of Type 1 Diabetes in ChildrenRecruitingNCT050543611 country
- T1CARE: A Trial of a Novel Intervention to Address Social Determinants of Health in Young Adults With Type 1 DiabetesRecruitingNCT07059806Not applicable1 country
- Washed Microbiota Transplantation for Type 1 Diabetes MellitusRecruitingNCT062566141 country
- Clinical Study to Evaluate the Impact of the Accu-Chek SmartGuide CGM Solution on the Mean Change in Time in Range Compared With Self-Monitoring of Blood Glucose in Participants With Type 1 and Type 2 Diabetes MellitusRecruitingNCT06704672Not applicable2 countries
- Early Detection of Type 1 Diabetes in First Degree Relatives of Type 1 Diabetes Patients (DETECT T1D GULF)RecruitingNCT07038473Not applicable3 countries
- Lean Mass Changes With Semaglutide in Adults With Type 1 Diabetes and Overweight/Obesity.RecruitingNCT07891156Phase 2/31 country
- MENA/Levant Epidemiological, Registry of Immunological & Clinical Traits (MERIT)Not yet recruitingNCT078926511 country
- Mitigating DKA in Type 1 Diabetes for Safe Use of SGLT Inhibitors Using Dual Continuous Ketone and Glucose Monitoring.Not yet recruitingNCT07325201Phase 21 country
- A Phase 2 Two-Part Study of Oral PS1 in Healthy Volunteers and Adults With Newly Diagnosed Type 1 DiabetesNot yet recruitingNCT07889505Phase 2
- Changes in Person-reported Outcomes and Behavior Using the Accu-Chek SmartGuide CGM and Predict AppRecruitingNCT07814508Not applicable1 country
- Verapamil In Preclinical Type 1 DiabetesNot yet recruitingNCT07880769Phase 2/31 country
- Sleep Coach for Adolescents With Type 1 DiabetesRecruitingNCT06516614Not applicable1 country
- Cardiometabolic Effects of Non-Nutritive Sweeteners (NNS) in Type 1 Diabetes (T1D)RecruitingNCT07434544Not applicable1 country
- A Study of GNTI-122 in Adults Recently Diagnosed With T1DRecruitingNCT06919354Phase 11 country
- Denosumab for Type 1 DiabetesRecruitingNCT06524960Phase 1/21 country
- dApagliflozin SC0062 and Prevention of Renal Injury; a Randomized EvaluationNot yet recruitingNCT06072326Phase 22 countries