Insulin Resistance clinical trials
The registry lists 2,969 studies for Insulin Resistance across more than 10 countries. 338 are recruiting or about to start. 713 of them are mainly about Insulin Resistance (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its narrower condition Metabolic Syndrome too: 4,764 studies, 640 open.
ClinicalTrials.gov finds 5,081 studies for Insulin Resistance. How that becomes 2,966 here
This page counts the studies the registry files under Insulin Resistance, and those it files under no condition that list Insulin Resistancethemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 5,081Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −1,775Filed under a narrower condition, counted on its own pageMetabolic Syndrome 1,775
- −4List Insulin Resistance as a condition, but the registry did not file them under itMost often written as “Systemic Insulin Resistance” (1), “Type 2 Diabetes Mellitus With Features of Insulin Resistance” (1), and “Obesity-Associated Insulin Resistance” (1). The registry filed them under other conditions only, most often Diabetes Mellitus, Type 2 (2) and Non-alcoholic Fatty Liver Disease (1).
- −336Match it another way267 name it in the title, 10 in a keyword, and 59 by a synonym or other text the search reads.
- 2,966The count on this page5 of them list Insulin Resistance in their own words; the registry filed them under no condition.
Get an email when these change. Save the Insulin Resistance studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
University of Aarhus (45) · Massachusetts General Hospital (44) · Maastricht University Medical Center (44) · University of Copenhagen (37) · Pennington Biomedical Research Center (35) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (35) · Stanford University (33) · University of Alabama at Birmingham (27)
What is being tested here
Drugs under test in Insulin Resistance studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Metformin | 8 | 25 | 120 |
| Insulin | 8 | 11 | 84 |
| Semaglutide | 8 | 6 | 11 |
| Insulin, Regular, Human | 4 | 3 | 29 |
| Empagliflozin | 4 | 4 | 10 |
| Tirzepatide | 4 | 0 | 4 |
| Pioglitazone | 2 | 5 | 47 |
| Glucagon | 2 | 1 | 14 |
| Human Growth Hormone | 2 | 0 | 12 |
| Probiotic | 2 | 0 | 7 |
Drug classes tested here GLP-1 receptor agonists 13 open · SGLT2 inhibitors 4 open · Corticosteroids 2 open · DPP-4 inhibitors 1 open · Diuretics 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Jan 2027A Clinical Trial to Evaluate The Effects of Semaglutide and Empagliflozin Combined to Automated Insulin Delivery on Diabetes Control in Adults Living With Type 1 Diabetes · Phase 3 · McGill University Health Centre/Research Institute of the McGill University Health Centre
- Jan 2027Alleviating Carbohydrate Counting for Patients with Type-1 Diabetes Using a Closed Loop System with Weekly Subcutaneous Semaglutide · Phase 3 · McGill University Health Centre/Research Institute of the McGill University Health Centre
- Feb 2027Fiber and Metformin Combination Therapy in Adolescents With Severe Obesity and Insulin Resistance · Phase 3 · University of Alberta
- Feb 2027Effect of a Multidomain Intervention Plus Turmeric on the Prevention of Cognitive Decline in People Over 55 Years of Age With Insulin Resistance. · Phase 3 · Instituto Mexicano del Seguro Social
- Mar 2027Effect of Metformin Use on Weight Loss in Obese, Non-diabetic People (MOWRI) · Phase 3 · University Of Nigeria Teaching Hospital
- Nov 2026Effect of Daily Erythritol Versus Sucrose Intake Over 5 Weeks on Glucose Tolerance in Adolescents · University Hospital, Basel, Switzerland
- Nov 2026SIRAKI 02 Posthoc Analysis. · Hospital Universitari de Bellvitge
- Nov 2026Role of Metformin on Muscle Health of Older Adults · University of Utah
- Nov 2026Effects of Sweetener Consumption on Risk Factors for Heart Disease in Prediabetic Subjects · Charite University, Berlin, Germany
- Nov 2026Continuous Glucose Monitoring By DExcom iN PEople Followed for Type 2 DIabeTes on Insulin Therapy in the Kingdom of Saudi Arabia · DexCom, Inc.
Who these studies take
Of the 244 Insulin Resistance studies recruiting now, 54 (22%) set no upper age limit and 158 (65%) stop at 75 or younger. 30 (12%) take children under 18. 42 (17%) are for women only and 3 (1%) for men only; 113 (46%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 16 (7%) | 13 (5%) |
| 18 | 162 (66%) | 136 (56%) |
| 30 | 191 (78%) | 159 (65%) |
| 40 | 198 (81%) | 164 (67%) |
| 50 | 175 (72%) | 154 (63%) |
| 65 | 158 (65%) | 139 (57%) |
| 75 | 104 (43%) | 89 (36%) |
| 85 | 68 (28%) | 54 (22%) |
Across all 2,969 studies, recruiting or not: 70% stop at 75 or younger and 53% at 65; 13% take children; 13% are for women only and 9% for men only; 46% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Insulin Resistance studies take
Of 73 phase 4 interventional studies under Insulin Resistance, half reached primary completion within 21 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 24 mo13–67 · 65 studies | — | 26 mo14–80 · 51 studies |
| Phase 2 | 45 mo25–64 · 59 studies | — | 46 mo27–65 · 49 studies |
| Phase 2/3 | 18 mo10–53 · 15 studies | — | — |
| Phase 3 | 28 mo17–53 · 44 studies | — | — |
| Phase 4 | 21 mo9–44 · 73 studies | — | 29 mo9–57 · 63 studies |
| Interventional, no phase | 21 mo9–40 · 754 studies | 9 mo3–22 · 40 studies | 22 mo10–41 · 714 studies |
| Observational | 53 mo18–143 · 133 studies | — | 53 mo18–142 · 130 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting4
- Improving Sleep Health and Circadian Timing to Support Cardiometabolic Health in AdolescentsNov 5, 2026NCT07618117
- Food-i-Sense Analytics: Integrating AI Into Continuous Glucose Monitoring Data Analysis for Precision Nutrition.Nov 5, 2026NCT07626658
- Trial to Evaluate ALN-CIDEB in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)Nov 2, 2026NCT07854782
- Inositol and Metformin Administration in Mediterranean Diet and Low-Carbohydrate Diets in Women With PCOSOct 16, 2026NCT07770711
Results posted2
- Inositol Supplementation to Treat PCOS (INSUPP-PCOS)Oct 28, 2026NCT03864068
- The Effects of Glucagon on Hepatic MetabolismOct 14, 2026NCT05500586
Stopped2
- Probiotics and Insulin Resistance in Obese AsthmaticsTerminatedNov 5, 2026NCT05949255
- Metabolic Heterogeneity Underlying Hypertriglyceridemia: Hepatic Triglyceride Biosynthesis in Humans With Different Insulin Resistance PhenotypesTerminatedOct 27, 2026NCT05743868
Newly registered8
- Mechanisms of Fasting-Induced Insulin ResistanceNov 10, 2026NCT07928297
- Relacorilant in Patients With Poorly Controlled Type 2 Diabetes and Autonomous Cortisol SecretionNov 9, 2026NCT07925801
- Exercise and Protein to Reduce Muscle Loss During GLP-1-Based Treatment in Type 2 DiabetesNov 9, 2026NCT07926152
- Effect of Probiotics on Insulin Sensitivity in Overweight and Obese PregnancyNov 6, 2026NCT07921940
- Asprosin and miRNA Expression in Young Women With Metabolic SyndromeNov 4, 2026NCT07917364
Show 3 moreShow fewer
- The Effect of Liraglutide on Body Weight, Body Composition, Ectopic Lipid Accumulation and Insulin Sensitivity in Subjects With Overweight or Obesity Without DiabetesNov 3, 2026NCT07913685
- IGOB131 As A GLP-1 Modulator For Metabolic Disorders In Adults With ObesityOct 20, 2026NCT07884058
- Peripheral Vascular Effects of Insulin in ObesityOct 15, 2026NCT07874945
Studies
Recruiting first, then most recently updated. Showing 50 of 2,969. Browse all 2,969 → or search them.
- Trial of the Combination of Alpha-Lipoic Acid and Mirabegron in Women and in Men With ObesityNot yet recruitingNCT05713799Phase 21 country
- Mechanisms of Fasting-Induced Insulin ResistanceNot yet recruitingNCT07928297Not applicable
- Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55 >= Years Old: A Randomized Triple-Masked Controlled Clinical TrialRecruitingNCT06274749Not applicable1 country
- Genetic Studies of Insulin and DiabetesRecruitingNCT000019871 country
- Relacorilant in Patients With Poorly Controlled Type 2 Diabetes and Autonomous Cortisol SecretionNot yet recruitingNCT07925801Phase 1/21 country
- Exercise and Protein to Reduce Muscle Loss During GLP-1-Based Treatment in Type 2 DiabetesNot yet recruitingNCT07926152Not applicable1 country
- Impact of Dietary Fat and Menstrual Cycle Phases in Type 1 DiabetesNot yet recruitingNCT07278063Not applicable1 country
- Probiotics, Cognition and Metabolic Health in Young Adults With Overweight or ObesityRecruitingNCT07073781Not applicable1 country
- Improving Sleep Health and Circadian Timing to Support Cardiometabolic Health in AdolescentsRecruitingNCT07618117Not applicable1 country
- Trial to Evaluate ALN-CIDEB in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)RecruitingNCT07854782Phase 31 country
- Food-i-Sense Analytics: Integrating AI Into Continuous Glucose Monitoring Data Analysis for Precision Nutrition.RecruitingNCT076266581 country
- Asprosin and miRNA Expression in Young Women With Metabolic SyndromeRecruitingNCT079173641 country
- Tirzepatide for Treatment of CCCARecruitingNCT07734870Phase 21 country
- cfMSC Therapy for DiabetesNot yet recruitingNCT07495956Phase 1/21 country
- Genetics of Skeletal Muscle Insulin ResistanceRecruitingNCT07780513Not applicable1 country
- Intermittent Fasting Versus Carbohydrate Drinks Before SurgeryRecruitingNCT05760339Not applicable1 country
- The Effects of Glucagon on Hepatic Metabolism in People With Type 2 Diabetes After Caloric RestrictionNot yet recruitingNCT05499702Phase 21 country
- Metabolic Phenotyping in vEDSRecruitingNCT075164961 country
- Washed Microbiota Transplantation for Type 1 Diabetes MellitusRecruitingNCT062566141 country
- Taste Bud-Derived Stem Cells in HumansRecruitingNCT033661681 country
- Postprandial Glucose Handing in Contraceptive and IUD UsersRecruitingNCT071695911 country
- Study of the Effect of Innate on the Inflammatory Response to EndotoxinRecruitingNCT011434801 country
- Fiber and Metformin Combination Therapy in Adolescents With Severe Obesity and Insulin ResistanceRecruitingNCT04578652Phase 31 country
- Improving Glycemic Control With Electrical StimulationRecruitingNCT03947697Not applicable1 country
- IGOB131 As A GLP-1 Modulator For Metabolic Disorders In Adults With ObesityNot yet recruitingNCT07884058Phase 2
- Neuromuscular Electrical Stimulation: A Novel Treatment for Improving MetabolismRecruitingNCT06722391Not applicable1 country
- Inositol and Metformin Administration in Mediterranean Diet and Low-Carbohydrate Diets in Women With PCOSRecruitingNCT07770711Not applicable1 country
- Peripheral Vascular Effects of Insulin in ObesityNot yet recruitingNCT07874945Early Phase 1
- Assessing Trauma-related Links Between Affective and Metabolic SystemsNot yet recruitingNCT07862712Phase 41 country
- Interplay of Central and Peripheral Vascular Effects of Insulin in ObesityNot yet recruitingNCT07653464Early Phase 11 country
- Understanding Metabolism and Inflammation Risks for Diabetes in AdolescentsRecruitingNCT060074041 country
- Whole-Food Magnesium for Mental and Cardiometabolic HealthNot yet recruitingNCT07865351Not applicable
- Effects of Different Fish Oil Types on Type 2 Diabetes Risk Factors in High-Risk AdultsRecruitingNCT07575438Phase 21 country
- Think-Find-Solve Activities for Insulin Self-Management in Type 1 DiabetesRecruitingNCT07670572Not applicable1 country
- DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational DiabetesRecruitingNCT06445946Phase 41 country
- RESET-INSPIRE Study: Insulin Sensitivity & Population Intervention With Real-time Evaluation Using CGMRecruitingNCT078611911 country
- Multimodal Risk Factor Graph Mapping, Metabolic Subtyping, and Digital Intelligent Chronic Disease Management for Prediabetes: An Integrated Cohort and Case-Control Clinical StudyNot yet recruitingNCT07854002
- Effects of Pistachios on Postprandial Metabolic Responses in Adults With Overweight or ObesityRecruitingNCT07853898Not applicable1 country
- Gauging Outcomes of Total Milk Ingestion on Lipid and gControlRecruitingNCT07087184Not applicable1 country
- Tirzepatide in Obesity-Driven Endometrial CancerRecruitingNCT07065552Early Phase 11 country
- Role of Alpha-to-beta Cell Communication to Adapt Insulin Secretion to Insulin Resistance.RecruitingNCT07224334Phase 11 country
- Restoring Vascular and Insulin Function To Augment Anti-Amyloid Therapy in Alzheimer's DiseaseNot yet recruitingNCT07756294Phase 21 country
- PREdiabetes GLycemic Impact and Data EvaluationRecruitingNCT07599072Not applicable1 country
- A Study of PATAS Using Single Ascending Doses in Healthy Volunteers and Multiple Ascending Doses in Diabetic SubjectsRecruitingNCT07223333Phase 11 country
- Vericiguat and Reverse Remodeling Indices in Heart FailureRecruitingNCT07405944Phase 41 country
- DIabetes GLycemic Assessment in Newly Confirmed EpisodesRecruitingNCT07690163Not applicable1 country
- Effects of Hourly Stair-Climbing Exercise Snacks on Metabolic and Vascular Health in Adults With PrediabetesRecruitingNCT07847684Not applicable1 country
- Diabetes, Insulin, Gut, Enteric Supplementation TrialRecruitingNCT07682077Not applicable1 country
- Metabolic and Hormonal Parameters in Women With Polyendocrine Metabolic Ovarian SyndromeNot yet recruitingNCT07844785
- Insomnia and Insulin ResistanceRecruitingNCT07333586Not applicable1 country