Hypoglycemia clinical trials
The registry lists 706 studies for Hypoglycemia across more than 10 countries. 94 are recruiting or about to start. 221 of them are mainly about Hypoglycemia (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 2 narrower conditions too, such as Congenital Hyperinsulinism: 730 studies, 95 open.
ClinicalTrials.gov finds 966 studies for Hypoglycemia. How that becomes 706 here
This page counts the studies the registry files under Hypoglycemia, and those it files under no condition that list Hypoglycemiathemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 966Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −23Filed under a narrower condition, counted on its own pageCongenital Hyperinsulinism 22 · Nesidioblastosis 1
- −50List Hypoglycemia as a condition, but the registry did not file them under itMost often written as “Neonatal Hypoglycemia” (15), “Hypoglycemia Unawareness” (12), and “Fear of Hypoglycemia” (5). The registry filed them under other conditions only, most often Diabetes Mellitus, Type 1 (20) and Premature Birth (7).
- −187Match it another way118 name it in the title, 17 in a keyword, and 52 by a synonym or other text the search reads.
- 706The count on this page42 of them list Hypoglycemia in their own words; the registry filed them under no condition.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
Institut de Recherches Cliniques de Montreal (27) · Steno Diabetes Center Copenhagen (17) · Joslin Diabetes Center (15) · University of Minnesota (13) · Insel Gruppe AG, University Hospital Bern (12) · Yale University (11) · Zealand Pharma (11) · Jaeb Center for Health Research (10)
What is being tested here
Drugs under test in Hypoglycemia studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Avexitide | 3 | 1 | 10 |
| Fluorodopa F 18 | 2 | 0 | 2 |
| Atropine | 2 | 0 | 2 |
| Glucagon | 1 | 7 | 30 |
| Insulin Glargine | 1 | 1 | 9 |
| Insulin Aspart | 1 | 1 | 8 |
| Glucose | 1 | 1 | 6 |
| Ersodetug | 1 | 2 | 4 |
| Glucagon-Like Peptide 1 | 1 | 0 | 4 |
| Dapagliflozin | 1 | 0 | 4 |
Drug classes tested here SGLT2 inhibitors 1 open · GLP-1 receptor agonists 13 · DPP-4 inhibitors 12 · Bronchodilators 5 · Opioid antagonists 4
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Sep 2027A Phase 3 Study of Ersodetug in Patients With Tumor Hyperinsulinism · Phase 3 · Rezolute
- Nov 2026A Study of LY3938577 in Participants With Type 2 Diabetes Previously Treated With Basal Insulin · Eli Lilly and Company
- Nov 2026Dumping Syndrome and Esophageal Atresia · University Hospital, Lille
- Nov 2026Hypoglycemia and the Gut Microbiome · Joslin Diabetes Center
- Nov 2026GlycoQuest: An AI-Adaptive CGM-Integrated Serious Game for Pediatric Type 1 Diabetes · Shifa International Hospital
- Nov 2026DiGESTnewborn Study · Cambridge University Hospitals NHS Foundation Trust
- Dec 2026Mechanisms of Hypoglycemia in Patients Without Diabetes · Joslin Diabetes Center
- Dec 2026Closed Loop Glucose Control in a Simulated ICU Setting · Ideal Medical Technologies
- Dec 2026Pilot Study Evaluating Safety of ExOlin® in Patients With Poorly Controlled Type 1 Diabetes · Defymed
- Dec 2026A Study of the Effect of ZT-01 on Night-time Hypoglycemia in Type 1 Diabetes · Zucara Therapeutics Inc.
Who these studies take
Of the 59 Hypoglycemia studies recruiting now, 23 (39%) set no upper age limit and 31 (53%) stop at 75 or younger. 18 (31%) take children under 18. 3 (5%) are for women only and 0 (0%) for men only; 14 (24%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 12 (20%) | 12 (20%) |
| 18 | 49 (83%) | 46 (78%) |
| 30 | 47 (80%) | 44 (75%) |
| 40 | 47 (80%) | 44 (75%) |
| 50 | 43 (73%) | 41 (69%) |
| 65 | 41 (69%) | 39 (66%) |
| 75 | 31 (53%) | 29 (49%) |
| 85 | 27 (46%) | 25 (42%) |
Across all 706 studies, recruiting or not: 58% stop at 75 or younger and 45% at 65; 23% take children; 3% are for women only and 4% for men only; 21% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Hypoglycemia studies take
Of 24 phase 2 interventional studies under Hypoglycemia, half reached primary completion within 12 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 20 mo7–105 · 21 studies | — | — |
| Phase 2 | 12 mo8–31 · 24 studies | — | — |
| Phase 3 | 14 mo4–29 · 17 studies | — | — |
| Phase 4 | 20 mo5–35 · 18 studies | — | — |
| Interventional, no phase | 17 mo7–33 · 175 studies | — | 18 mo8–33 · 169 studies |
| Observational | 22 mo12–52 · 53 studies | — | 22 mo12–52 · 52 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 12, 2026.
Started recruiting1
- Hypoglycemia Prevention in High-Risk Type 2 Diabetes PatientsOct 14, 2026NCT06746714
Results posted1
Newly registered4
- Inter-Arm Differences in Continuous Glucose Monitor Readings in Adults With DiabetesNov 5, 2026NCT07920341
- Relationship Between Insulin Dose and Complications in Type 1 DiabetesNov 2, 2026NCT07911033
- Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PAL-119 in Healthy Volunteers and Adult Participants With Type 1 or Type 2 DiabetesOct 28, 2026NCT07901595
- Hypoglycemia Risk Assessment in Elderly and Senile Female Patients With Type 2 Diabetes MellitusOct 21, 2026NCT07887334
Studies
Recruiting first, then most recently updated. Showing 50 of 706. Browse all 706 → or search them.
- An Expanded Access Protocol to Provide Avexitide in Patients With Post-Bariatric HypoglycemiaAvailableNCT075828741 country
- Clinical and Basic Investigations Into Known and Suspected Congenital Disorders of GlycosylationRecruitingNCT020897891 country
- Inter-Arm Differences in Continuous Glucose Monitor Readings in Adults With DiabetesNot yet recruitingNCT07920341Not applicable1 country
- Effect of Mizagliflozin on Hypoglycemia in Patients With Post-Bariatric HypoglycemiaRecruitingNCT07760961Phase 21 country
- Relationship Between Insulin Dose and Complications in Type 1 DiabetesNot yet recruitingNCT079110331 country
- Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PAL-119 in Healthy Volunteers and Adult Participants With Type 1 or Type 2 DiabetesNot yet recruitingNCT07901595Phase 1/2
- Washed Microbiota Transplantation for Type 1 Diabetes MellitusRecruitingNCT062566141 country
- Preoperative Fasting and Perioperative Outcomes in Children Undergoing Elective CircumcisionNot yet recruitingNCT07876583
- Diagnosing and Treating Low Blood Sugar LevelsRecruitingNCT000012761 country
- Study of the Safety and Efficacy of Pancreatic Endocrine Cells in Adult Patients With Type 1 DiabetesNot yet recruitingNCT07581197Phase 1/2
- Dietary, Medication, and Endoscopic Interventions for Post-Bariatric HypoglycemiaNot yet recruitingNCT07878494Not applicable1 country
- Improving Islet Transplantation Outcomes With Gastrin for Type I DiabetesRecruitingNCT03746769Phase 1/21 country
- The Real-World Control-IQ Glycemic Control and Quality of Life Study in Type 1 Diabetes in FranceRecruitingNCT072111261 country
- Hypoglycemia Prevention in High-Risk Type 2 Diabetes PatientsRecruitingNCT06746714Not applicable1 country
- Intermediate-Size Cohort EAP for Ersodetug in Patients With Inadequately Controlled Hypoglycemia Related to a TumorAvailableNCT072629701 country
- Enhancing Shared Decision-making to Guide Care for People With Dementia and DiabetesRecruitingNCT05643144Not applicable1 country
- A Phase 3 Study of Ersodetug in Patients With Tumor HyperinsulinismRecruitingNCT06881992Phase 35 countries
- Evaluation of the Psychometric Properties of the Turkish Version of the Hypoglycaemia Self-Care Behaviour ScaleEnrolling by invitationNCT073166991 country
- FEAR of HYPOGLYCEMIA in PATIENTS WITH DIABETESRecruitingNCT073299851 country
- Post-Prandial Carbohydrate Metabolism in Individuals With and Without Post-Bariatric Surgery Hypoglycemia (PBH)RecruitingNCT07818707Phase 41 country
- Comparing Glycemic Outcomes of Carbohydrate Counting vs. Fixed Mealtime Insulin Dosing in Hospitalized Patients With HyperglycemiaNot yet recruitingNCT07808398Not applicable
- Alcohol After Bariatric Surgery 2RecruitingNCT062577711 country
- A Safety, Tolerability, and Efficacy Study of VX-880 and VX-017 in Participants With Type 1 DiabetesRecruitingNCT04786262Phase 310 countries
- A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes MellitusRecruitingNCT06575426Phase 1/21 country
- Implementation of Networked Continuous Glucose Monitoring With Telemetry Within the Intensive Care Unit (ICU-TeleCGM)Not yet recruitingNCT077691381 country
- Comparison of Hormonal Response to a Mixed-Meal Tolerance Test After Laparoscopic Roux-en-Y Gastric Bypass Versus Laparoscopic Sleeve Gastrectomy With Duodenojejunal Bypass in Patients With Super Morbid ObesityRecruitingNCT07747779Not applicable1 country
- The BRIGHT Study (Device Name: HALO System)Not yet recruitingNCT07745998Not applicable
- Safer Aging With Diabetes MonitoringRecruitingNCT06296485Not applicable1 country
- GlycoQuest: An AI-Adaptive CGM-Integrated Serious Game for Pediatric Type 1 DiabetesRecruitingNCT07726680Not applicable1 country
- Miniaturized Breath-based Sensor for the Detection of Hypo- and HyperglycemiaRecruitingNCT07696273Not applicable1 country
- Perioperative Hypoglycemia in Diabetic Patients Undergoing Vitrectomy: a Masked CGM Prospective Observational StudyNot yet recruitingNCT07696910
- Behavioural Problems and Cognition in Children With Hypoglycemia Unawareness in Type-1 Diabetes MellitusNot yet recruitingNCT06488469Not applicable1 country
- Impact of MEnstruation on Glycemic Response and Exercise In Females With Type 1 DiabetesRecruitingNCT06297980Not applicable1 country
- Closed Loop Glucose Control in a Simulated ICU SettingNot yet recruitingNCT07646067Not applicable
- Diabetes Clinical Decision SupportRecruitingNCT05447806Not applicable1 country
- Adapted Mindfulness Training for Diabetic Patients With Impaired Hypoglycemia AwarenessNot yet recruitingNCT07586527Not applicable
- Monitoring Exhaled Breath to Noninvasively Detect Glycemic EventsRecruitingNCT06893341Not applicable1 country
- Anakinra for the Treatment of Postprandial Hypoglycemia in a Patient With Total Gastrectomy and End-Stage Renal DiseaseNot yet recruitingNCT07580079Phase 21 country
- A Study of Glycemic Control in Left Ventricular AssistRecruitingNCT059331611 country
- Lower vs. Standard Insulin-Dextrose Doses for Treating Mild to Moderate Hyperkalemia in the Emergency DepartmentEnrolling by invitationNCT06724991Not applicable1 country
- Prebiotics in Patients With Type 1 DiabetesRecruitingNCT04963777Not applicable1 country
- A Study of the Effect of ZT-01 on Night-time Hypoglycemia in Type 1 DiabetesRecruitingNCT05762107Phase 22 countries
- 18F-L-Fluoro-DOPA PET/CT Scan Localization of Focal Pancreatic Lesions in Subjects With Hyperinsulinemic HypoglycemiaAvailableNCT019161481 country
- Developing a Colonoscopy Preparation Protocol for Patients With DiabetesNot yet recruitingNCT07526103Not applicable1 country
- Validation of Remote Photoplethysmography for Non-Invasive Estimation of Blood Glucose and HbA1cNot yet recruitingNCT075026901 country
- A Study of Endocrine, Metabolic, and Genetic Risk Factors of Pediatric Persistent Hypoglycemia at Sohag University HospitalNot yet recruitingNCT075333181 country
- Hypoglycemia Fear Affect Autonomic Function, Physical Activity, and Exercise Capacity in Type I DiabetesNot yet recruitingNCT075276761 country
- Effect of Ambient Temperature on Blood Glucose and Insulin Absorption in Adults With Type 1 DiabetesNot yet recruitingNCT07491133Not applicable1 country
- Efficacy and Safety of a Ketogenic Diet in Type 1 DiabetesRecruitingNCT06503809Not applicable1 country
- Cortisol and Obesity - A Vicious Cycle? Hypoglycemia After Bariatric Surgery - Association With Cortisol Metabolism?RecruitingNCT068966821 country