Mydriasis clinical trials
The registry lists 37 studies for Mydriasis across more than 10 countries. 4 are recruiting or about to start. 19 of them are mainly about Mydriasis (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-30.
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Who runs them
Eyenovia Inc. (5) · Opus Genetics, Inc (4) · Khon Kaen University (3) · Assistance Publique - Hôpitaux de Paris (2) · Aristotle University Of Thessaloniki (2) · Carmel Medical Center (1) · Tel-Aviv Sourasky Medical Center (1) · The University of Texas Medical Branch, Galveston (1)
What is being tested here
Drugs under test in Mydriasis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Phentolamine | 0 | 3 | 4 |
| Tropicamide | 0 | 3 | 4 |
| Phenylephrine | 0 | 3 | 4 |
| Ketorolac | 0 | 1 | 2 |
| Brimonidine | 0 | 0 | 1 |
| Lidocaine | 0 | 0 | 1 |
| Atropine | 0 | 0 | 1 |
| Epinephrine | 0 | 0 | 1 |
| Prednisolone acetate | 0 | 0 | 1 |
| Prednisolone | 0 | 0 | 1 |
Drug classes tested here Antimuscarinics 5
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The study
- Mar 2027The Correlation Between Pupil Size and Retinal Nerve Fibers Changes in Pseudoexfoliation Syndrome. · Assiut University
Who these studies take
Of the 3 Mydriasis studies recruiting now, 0 (0%) set no upper age limit and 1 (33%) stop at 75 or younger. 1 (33%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (67%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (33%) | 1 (33%) |
| 18 | 2 (67%) | 2 (67%) |
| 30 | 2 (67%) | 2 (67%) |
| 40 | 2 (67%) | 2 (67%) |
| 50 | 2 (67%) | 2 (67%) |
| 65 | 2 (67%) | 2 (67%) |
| 75 | 2 (67%) | 2 (67%) |
| 85 | 0 (0%) | 0 (0%) |
Across all 37 studies, recruiting or not: 32% stop at 75 or younger and 27% at 65; 38% take children; 0% are for women only and 0% for men only; 43% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 37 of 37. search them.
- Cochlear Implanted Listening Effort and Hearing AttentionRecruitingNCT04733950Not applicable1 country
- Comparing Efficacy and Safety of CTO0303 in Pediatric SubjectsRecruitingNCT06609525Phase 2/31 country
- The Correlation Between Pupil Size and Retinal Nerve Fibers Changes in Pseudoexfoliation Syndrome.Not yet recruitingNCT06588816
- Sutureless Intrascleral Intraocular Lens Fixation and Modified Iris Cerclage PupilloplastyRecruitingNCT05829122Not applicable1 country
- Safety and Efficacy of Nyxol (0.75% Phentolamine Ophthalmic Solution) to Reverse Pharmacologically-Induced Mydriasis (MIRA-3)CompletedNCT05134974Phase 31 country
- Safety and Efficacy of Ophthalmic Phentolamine Mesylate to Reverse Pharmacologically Induced MydriasisCompletedNCT04024891Phase 21 country
- Safety and Efficacy of Nyxol (0.75% Phentolamine Ophthalmic Solution) to Reverse Pharmacologically-Induced MydriasisCompletedNCT04620213Phase 31 country
- Nyxol (0.75% Phentolamine Ophthalmic Solution) to Reverse Pharmacologically-Induced Mydriasis in Pediatric SubjectsCompletedNCT05223478Phase 31 country
- Pharmacodynamics of a Fixed Dose Combination of 0.34% Tropicamide and 2.5% Phenylephrine Hydrochloride, Eye Drop, SolutionCompletedNCT07075224Phase 1/21 country
- Comparison of 4 Methods of Eye Drops for Pupil Dilation in Diabetic PatientsCompletedNCT07495670Not applicable1 country
- Comfort Level in Premature Infants Undergoing Retinopathy of Prematurity ScreeningCompletedNCT07016984Not applicable1 country
- Efficacy and Safety of Mydriatic Microdrops for Retinopathy Of Prematurity ScreeningCompletedNCT05043077Phase 41 country
- Evaluation of Pupil Dilation Speed With the MAP DispenserCompletedNCT04907474Phase 41 country
- The Effect of Eyedrop Size on Pupillary Dilation Using the Nanodropper Bottle AdapterCompletedNCT06689904Not applicable1 country
- Safety and Efficacy of Fixed Combination Phenylephrine-Tropicamide for Pupil DilationCompletedNCT06217796Phase 41 country
- Efficacy Mydrane ® for Cataract Surgery in Patients With Concomitant Primary Open Angle Glaucoma.CompletedNCT05925894Not applicable1 country
- The Effects of Mydriatic Eye Drops in Retinopathy of Prematurity ExaminationsCompletedNCT058804331 country
- Study of the Safety, Efficacy and PK of EYN-1601 in Dilation of the PupilCompletedNCT02946125Phase 21 country
- Efficacy and Safety of Mydriatic Microdrops Compared With Standard Drops for Retinopathy of Prematurity (ROP) Screening: a Pilot Randomized Clinical TrialCompletedNCT04623684Phase 41 country
- Safety and Efficacy of Phenylephrine 2.5%-Tropicamide 1% Microdose Ophthalmic Solution for Pupil DilationCompletedNCT03751098Phase 31 country
- Safety and Efficacy of Phenylephrine 2.5%-Tropicamide 1% Microdose Ophthalmic Solution for Pupil DilationCompletedNCT03751631Phase 31 country
- Stimulation and Validation of the Pupillary Dilation for the Detection of Pain in Analgosedated Patients Under Mechanically Ventilation in Intensive Care UnitStatus unknownNCT04078113Not applicable1 country
- Effect of Intracameral Injection of Mydriatic Plus Anaesthetic Combination on Corneal Endothelial Count in PhacoCompletedNCT04396301Phase 31 country
- Subconjunctival Atropine and Intracameral Epinephrine for Pupil Dilation in PhacoemulsificationStatus unknownNCT03638726Phase 41 country
- The Effect of Brimonidine on Intraocular Pressure When Dilating Routine PatientsCompletedNCT03139708Phase 11 country
- Interest of a Tetanus Test at a Fixed Remifentanil Concentration Before Laryngoscopy and Skin IncisionCompletedNCT02884310Phase 4
- "Eye Protection After Mydriatic Use for ROP Screening: Impact on Vitals Signs and Pain Scores"CompletedNCT01860534Not applicable1 country
- Intracameral Mydriasis Versus Topical Mydriasis in Cataract SurgeryTerminatedNCT00690222Not applicable1 country
- Lidocaine Usage for Pupil Dilatation (Mydriasis)CompletedNCT01170130Not applicable
- Topical 0.4% Ketorolac and Vitreoretinal SurgeryCompletedNCT00576329Phase 2/31 country
- Evaluation of the FIM - a Non Invasive Device for Temporarily and Quick Pupil Dilation (Mydriasis)Status unknownNCT01946828Not applicable1 country
- Comparison of Instillation and Packing in Mydriasis for Premature InfantsCompletedNCT00877175Phase 41 country
- Single Dose of 1% Tropicamide and 10% Phenylephrine for Pupillary DilationCompletedNCT00120432Phase 31 country
- 2.5% and 10% Phenylephrine for Mydriasis in Diabetic Patients With Darkly Pigmented IridesCompletedNCT00501878Phase 41 country
- Effect of Anti-inflammatory Topical Prednisolone, Nepafenac and Ketorolac in Intra-operative Mydriasis in FacetectomiesStatus unknownNCT00865540Phase 41 country
- Preoperative Cataract Pupillary Dilation: Inpatient At The Ambulatory Surgery Center vs Outpatient Dilation Prior To Arrival At The Ambulatory Surgery CenterCompletedNCT01169688Not applicable
- CLAIR -FO: Clinical Trial of Ophthalmic Insert Mydriasert® Versus Reference TreatmentTerminatedNCT00642135Phase 31 country