Methadone: all 164 studies that test it

Page 1 of 2. Open to participants first (28), then studies with results posted, then the rest; newest registration first within each.

• Intraoperative Methadone for the Management of Postoperative Pain in Patients With Head and Neck CancersRecruitingNCT07857655Phase 4
• Subcutaneous Methadone for Cesarean Analgesia: a Non Inferiority Study Using QoR-10Not yet recruitingNCT07777029Not applicable
• A Study of Ulonivirine (MK-8507) and Methadone in Healthy Volunteers (MK-8507-019)RecruitingNCT07595263Phase 1
• Methadone for Enhanced Postoperative Analgesia in Intermediate-Risk Noncardiac Surgery (MELODY)Not yet recruitingNCT07565870Phase 3
• Methadone Rapid RestartNot yet recruitingNCT07546396Phase 4
• Methadone for Post-operative Spine SurgeryRecruitingNCT07517679Phase 4
• Methadone in the Management of Post-Operative Pain in Total Knee ReplacementRecruitingNCT07485803Phase 4
• Methadone in THA for Post-op Pain and Opioid ReductionRecruitingNCT07227064Phase 3
• Methadone in TKA for Post-op Pain and Opioid ReductionRecruitingNCT07226076Phase 3
• Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility StudyRecruitingNCT07222072Phase 4
• Optimizing Perioperative Analgesia to Lower Pain Following Cleft Palate SurgeryRecruitingNCT06962306Phase 4
• MethaLoad Dose-Finding StudyRecruitingNCT06877858Phase 1
• Pain Control and Quality of Recovery After Intravenous Methadone Versus Intravenous Remifentanil in Craniotomy SurgeryRecruitingNCT06810336Early Phase 1
• Sufentanil Infusion vs Intravenous Methadone for Postoperative Analgesia Following Head and Neck Dissection With Free Flap or Rotational ReconstructionRecruitingNCT06784999Phase 4
• Intrathecal Morphine Versus Intravenous Methadone for Postoperative Analgesia Following Retroperitoneal Lymph Node Dissection.RecruitingNCT06593665Phase 3
• Optimization of Pediatric Tonsillectomy to IMprove AnaLgesiaRecruitingNCT06576830Phase 4
• The Effects of One-time Intraoperative Methadone During Laparoscopic Hysterectomy in Reducing Opioid Prescription.RecruitingNCT06536517Phase 2
• Methadone Versus Intrathecal Hydromorphone for Postoperative Pain Relief in Gynecologic Cancer Undergoing SurgeryRecruitingNCT06525740Phase 4
• Pain Control and Quality of Recovery After Intravenous Methadone Versus Intrathecal Morphine in Major Abdominal SurgeryRecruitingNCT06387303Early Phase 1
• PO Methadone Ortho OutpatientNot yet recruitingNCT06351215Phase 3
• Office-based Methadone Versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder Treatment.RecruitingNCT06323824Phase 4
• Intraoperative Methadone for the Prevention of Postoperative PainRecruitingNCT05831345Phase 3
• Interaction of CYP2B6 Genotype and Efavirenz With Methadone and Tizanidine PKRecruitingNCT05789173Early Phase 1
• Methadone to Treat Painful Chemotherapy Induced Peripheral NeuropathyRecruitingNCT05786599Phase 2/3
• Divided or Single Exposure (DOSE) StudyRecruitingNCT05459402Phase 2/3
• Intraoperative Methadone for Postoperative Pain in Patients Undergoing TonsillectomyRecruitingNCT05445856Phase 4
• Effect of Methadone and Hydromorphone on the QT Interval After Anesthesia and SurgeryRecruitingNCT03893734Phase 4
• Methadone and Quality of Postoperative RecoveryRecruitingNCT03168958Phase 4
• Impact of Methadone on Prolonged Mechanical Ventilation in Patients on Continuous Treatment With OpioidsTerminatedNCT06110546Phase 4Results posted
• Randomized, Double-Blind, Placebo-Controlled Trial of REL-1017 as Adjunctive Treatment for MDDTerminatedNCT06011577Phase 3Results posted
• Single Dose IV Methadone for Post-Op PainCompletedNCT05425420Phase 1/2Results posted
• Pediatric Pain Optimization After TonsillectomyCompletedNCT05244226Phase 2Results posted
• A Study to Assess the Efficacy and Safety of REL-1017 as Monotherapy for Major Depressive Disorder (MDD)CompletedNCT05081167Phase 3Results posted
• Methadone and Medication AbortionTerminatedNCT04941443Phase 4Results posted
• Safety of REL-1017 for Major Depressive DisorderCompletedNCT04855760Phase 3Results posted
• A Study to Assess the Efficacy and Safety of REL-1017 as Adjunctive Treatment for Major Depressive Disorder (MDD)TerminatedNCT04855747Phase 3Results posted
• A Study to Assess the Efficacy and Safety of REL-1017 as Adjunctive Treatment for Major Depressive Disorder (MDD)CompletedNCT04688164Phase 3Results posted
• Anti-retroviral Therapy, Medications for Opioid Use Disorder, Opioids and HIV Infection - Study 1TerminatedNCT04480554Phase 2Results posted
• Trial to Shorten Pharmacologic Treatment of Newborns With Neonatal Opioid Withdrawal Syndrome (NOWS)Active, not recruitingNCT04214834Phase 3Results posted
• Optimizing Outpatient Anesthesia (OSPREy-Outpatient Surgery Pain Relief Enhancement)CompletedNCT03726268Phase 4Results posted
• Methadone Demonstration Project With Neonatal Intensive Care Unit Infants Diagnosed With Neonatal Abstinence SyndromeTerminatedNCT03134703Phase 2Results posted
• Safety, Tolerability, PK Profile, and Symptom Response of a 7-Day Dosing With 25 mg or 50 mg Daily of REL-1017 in MDDCompletedNCT03051256Phase 2Results posted
• Intraoperative Methadone Administration for Improved Pain Control in Spinal Fusion PatientsTerminatedNCT02989597Phase 4Results posted
• Morphine Versus Methadone for Opiate Exposed Infants With Neonatal Abstinence SyndromeCompletedNCT02851303Phase 4Results posted
• Methadone vs. Fentanyl Administration on Postoperative Pain Control in Pediatric Patients Undergoing Cardiac SurgeryTerminatedNCT02747875Not applicableResults posted
• Effects of Doravirine (MK-1439) on Methadone Pharmacokinetics in Methadone-Maintained Participants (MK-1439-045)CompletedNCT02715700Phase 1Results posted
• Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) ProphylaxisCompletedNCT02625181Not applicableResults posted
• Perioperative Methadone Use to Decrease Opioid Requirement in Pediatric Spinal Fusion PatientsCompletedNCT02558010Phase 3Results posted
• A Randomized Trial of Interim Methadone and Patient Navigation Initiated in JailCompletedNCT02334215Not applicableResults posted
• Methadone in Ambulatory SurgeryCompletedNCT02300077Not applicableResults posted
• The Effects of Ketamine and Methadone on Postoperative Pain for LaminectomyTerminatedNCT02252432Phase 4Results posted
• A Trial Comparing Single Intra-op Dose of Methadone Versus Placebo in Patients Undergoing Spine SurgeryCompletedNCT02206685Phase 4Results posted
• Methadone and Hydromorphone For Spinal SurgeryCompletedNCT02107339Phase 4Results posted
• Adjunct Methadone to Decrease the Duration of Mechanical Ventilation in the Medical Intensive Care UnitTerminatedNCT02025855Phase 4Results posted
• Improving Outcomes in Neonatal Abstinence SyndromeCompletedNCT01958476Phase 3Results posted
• Comparison Between Methadone and Morphine for Neonatal Opiate WithdrawalCompletedNCT01804075Phase 4Results posted
• Methadone vs Magnesium in Spinal FusionCompletedNCT01795495Phase 2Results posted
• Treatment of Neonatal Abstinence SyndromeCompletedNCT01723722Phase 4Results posted
• The Effect of Choice of Intraoperative Opioid on Postoperative PainCompletedNCT01542645Phase 4Results posted
• Intraoperative Methadone vs Morphine for Postoperative Pain Control in Patients Undergoing Surgery of the TibiaTerminatedNCT01430182Not applicableResults posted
• A Study to Evaluate the Pharmacokinetic Effect of SCH 503034 (Boceprevir) on Methadone or Buprenorphine/Naloxone Plasma Concentrations (P08123)CompletedNCT01396005Phase 1Results posted
• Measuring the Amount of Methadone or Morphine in the Blood of Neonates, Infants & Children After Cardiac Surgery.CompletedNCT01094522Phase 1/2Results posted
• Methadone in Pediatric AnesthesiaCompletedNCT00921843Phase 4Results posted
• Methadone Versus Morphine for Orthopedic Surgery PatientsCompletedNCT00892606Phase 4Results posted
• Combination Pain Therapy in HIV NeuropathyTerminatedNCT00863057Phase 2Results posted
• Methadone in Pediatric and Adult Sickle Cell PatientsCompletedNCT00761085Not applicableResults posted
• Methadone, Morphine, or Oxycodone in Treating Pain in Patients With CancerTerminatedNCT00726830Not applicableResults posted
• Morphine Versus Methadone As First Line Strong Opioid for Cancer PainTerminatedNCT00634010Phase 3Results posted
• Study of D-Methadone in Patients With Chronic PainCompletedNCT00588640Phase 1/2Results posted
• Methadone Versus Morphine for Cancer-Related PainTerminatedNCT00573937Phase 2Results posted
• Role of Methadone As Co-Opioid AnalgesicTerminatedNCT00558870Phase 2Results posted
• Comparison of A Single Dose Combination of Methadone and Morphine With Morphine Alone for Treating Post-operative PainCompletedNCT00142519Phase 2Results posted
• A Clinical Trial in Healthy Participants to Study the Effect of a Single Dose of MK-8527 on Levels of Methadone (MK-8527-020)CompletedNCT07528508Phase 1
• Oral Methadone in Cardiac SurgeryActive, not recruitingNCT07221617Phase 4
• The Impact of Intraoperative Methadone on Postoperative Opioid UseWithdrawnNCT07092475Phase 3
• Reducing Pain With Methadone and Ketamine in Liver TransplantCompletedNCT06868589Phase 4
• A Study to Evaluate the Efficacy and Safety of REL-1017 As Adjunctive Treatment of Major Depressive Disorder (MDD)WithdrawnNCT06735079Phase 3
• Intravenous Methadone for Sternotomy Pain Control in Cardiac SurgeryCompletedNCT06728371Phase 3
• Perioperative Methadone Compared to Placebo in Elderly Hip Fracture PatientsCompletedNCT06086171Phase 4
• Intravenous Methadone in Perioperative Acute and Chronic Management in Chinese Adult Cardiac Surgical PatientsCompletedNCT05913284Phase 3
• Intraoperative Methadone for Postoperative Pain ControlWithdrawnNCT05845359Phase 4
• Perioperative Methadone in Hip Fracture PatientsCompletedNCT05581901Phase 4
• Understanding How Methadone Treatment During Surgery Affects Pain Levels and the Need for Pain Medications After SurgeryActive, not recruitingNCT05417100Phase 3
• Medication-assisted Treatment for Injecting Drug Users in VietnamCompletedNCT05368675Phase 4
• Methadone for 'Adenocarcinopathic' Pain TreatmentWithdrawnNCT05325164Phase 3
• Study of LYN-014 in Individuals With Opioid Use Disorder Who Are Stable on Methadone TherapyWithdrawnNCT05251376Phase 1
• Effectiveness and Safety of Methadone Versus Placebo for the Control of Neuropathic Pain in Different EtiologiesCompletedNCT05235191Phase 3
• Methadone Anesthesia For Kidney Transplant ReceptorsStatus unknownNCT04908345Phase 3
• Methadone for Spinal Fusion Surgery.TerminatedNCT04764825Phase 4
• Intraoperative Methadone in Children Undergoing SurgeryTerminatedNCT04680286Phase 3
• Influence of Aging on Perioperative Methadone DosingCompletedNCT04526236Phase 4
• Intraoperative Methadone for Postoperative Pain Control After Thoracic SurgeryTerminatedNCT04525898Phase 4
• Methadone in Cystectomy PatientsCompletedNCT04475029Not applicable
• A Proof of Concept, Phase 2, Double-blind, Randomized Trial With d-Methadone Product Versus PlaceboSuspendedNCT04145674Phase 2
• Clinical Effectiveness of Pre-operative Methadone in Single Level Lateral Transpsoas Interbody FusionsStatus unknownNCT04112550Phase 1
• Cognitive Function and Pain Threshold in People Who Are Methadone MaintainedCompletedNCT04027166Early Phase 1
• Postoperative Pain and Headache After CraniotomyWithdrawnNCT03908944Phase 2
• Clinical Effectiveness and Safety of Intraoperative Methadone in Patients Undergoing Laparoscopic HysterectomyStatus unknownNCT03908060Not applicable
• Safety, Tolerability, and Pharmacokinetics of Multiple Ascending Doses of REL-1017 (d-Methadone)CompletedNCT03638869Phase 1
• Safety, Tolerability and Pharmacokinetics of Single Ascending Doses of REL-1017 (d-Methadone)CompletedNCT03637361Phase 1

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