Drug
Fluoxetine clinical trials
Also written Prozac, Sarafem and LY110140.
How each study uses Fluoxetine is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study
Get an email when these change. Save the Fluoxetine studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Approvals
The first approval found in each region, with its record
- United States
- 29 Dec 1987 · SARAFEM · NDA 018936 (FDA, Drugs@FDA)
- European Union
- Not in EMA's list of EU-wide authorisations
From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out
How studies write it
Studies that test it under each name
Studies by the year they started
159 studies that test it; most in 2001 (14)
| Year | Studies |
|---|---|
| 1990 | 1 |
| 1994 | 2 |
| 1995 | 2 |
| 1996 | 2 |
| 1997 | 2 |
| 1998 | 7 |
| 1999 | 3 |
| 2000 | 5 |
| 2001 | 14 |
| 2002 | 2 |
| 2003 | 3 |
| 2004 | 3 |
| 2005 | 8 |
| 2006 | 5 |
| 2007 | 5 |
| 2008 | 3 |
| 2009 | 9 |
| 2010 | 7 |
| 2012 | 7 |
| 2013 | 8 |
| 2014 | 8 |
| 2015 | 8 |
| 2016 | 3 |
| 2017 | 4 |
| 2018 | 3 |
| 2019 | 3 |
| 2020 | 7 |
| 2021 | 4 |
| 2022 | 4 |
| 2023 | 2 |
| 2024 | 5 |
| 2025 | 7 |
| 2026 | 3 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 18 · Other 142
New York State Psychiatric Institute (8) · Eli Lilly and Company (7) · University of Pittsburgh (6) · Massachusetts General Hospital (4) · Shanghai Mental Health Center (4) · University of California, Los Angeles (4) · University of Oxford (4) · National Institute of Mental Health (NIMH) (4)
Often tested with
Tested in the same studies.
Sertraline (7) · Olanzapine (7) · Citalopram (6) · Venlafaxine (5) · Bupropion (5) · Fluvoxamine (4) · Duloxetine (4) · Aripiprazole (4)
Related medicines
As reviewed, each with the page that says it.
Coming up
From the study records. Dates are the sponsors’ own estimates and often move.
Reaching primary completion within a year · 14
Studies that test Fluoxetine.
- Dec 2026Evaluation of Fluoxetine and Cytotoxic Lysosomal Stress in Glioma (FLIRT)Early Phase 1 · Duke University
- Dec 2026Fluoxetine on Emotional Experience (FLEX) StudyNot applicable · University of Oxford
- Dec 2026Sequenced Treatment Alternatives to Relieve Adolescent Depression (STAR-AD)Phase 1/2 · First Affiliated Hospital of Chongqing Medical University
- Jan 2027Finding Treatments for COVID-19: A Trial of Antiviral Pharmacodynamics in Early Symptomatic COVID-19 (PLATCOV)Phase 2 · University of Oxford
- Mar 2027Can Immediate Post-injury Fluoxetine Improve the Recovery Trajectories of Victims in Bodily Trauma?Phase 4 · University of Florida
- Apr 2027Study of Dextromethorphan in OCD and Related DisordersPhase 2 · Stanford University
- May 2027Identifying and Treating Depression in the Orthopaedic Trauma PopulationPhase 4 · Wake Forest University Health Sciences
- Jun 2027Evaluation of Fluoxetine for Refractory Constipation With Somatic Symptom Disorder FeaturesPhase 2 · Zhifeng Zhao, PhD
- Jul 2027Fluoxetine for the Modification of Colorectal Tumor Immune Cells Before Surgery in Patients With Colorectal CancerPhase 1 · Jonsson Comprehensive Cancer Center
- Jul 2027Fluoxetine and Understanding Social ExperiencesNot applicable · University of Oxford
Studies
Open first, then newest update. How each study uses Fluoxetine is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing it · 160
- Study of Neuro-Cognitive Correlates of Pediatric Anxiety DisordersRecruitingPhase 2National Institute of Mental Health (NIMH)NCT00018057Written as Fluoxetine
- Evaluation of Fluoxetine for Refractory Constipation With Somatic Symptom Disorder FeaturesNot yet recruitingPhase 2Zhifeng Zhao, PhDNCT06506136Written as Fluoxetine
- Fluoxetine for the Modification of Colorectal Tumor Immune Cells Before Surgery in Patients With Colorectal CancerRecruitingPhase 1Jonsson Comprehensive Cancer CenterNCT06225011Written as Fluoxetine
- Identifying and Treating Depression in the Orthopaedic Trauma PopulationRecruitingPhase 4Wake Forest University Health SciencesNCT05976347Written as Fluoxetine 20 MG
- Study of Dextromethorphan in OCD and Related DisordersRecruitingPhase 2Stanford UniversityNCT04899687Written as Fluoxetine
- Can Immediate Post-injury Fluoxetine Improve the Recovery Trajectories of Victims in Bodily Trauma?RecruitingPhase 4University of FloridaNCT06046859Written as Fluoxetine
- Psilocybe Cubensis Mushrooms With or Without Fluoxetine for Refractory DepressionRecruitingPhase 1/2Federal University of Latin American IntegrationNCT06898606Written as Fluoxetine
- SSRI Antidepressant Fluoxetine Improving Immunotherapy Efficacy in Advanced Hepatobiliary Malignancy Patients With Depression and AnxietyRecruitingPhase 2First Affiliated Hospital of Wenzhou Medical UniversityNCT07174947Written as Fluoxetine (drug)
- The Psychiatric and Cognitive Phenotypes in Velocardiofacial SyndromeRecruitingPhase 4The Chaim Sheba Medical CenterNCT00768820Written as methylphenidate, fluoxetin, risperidone
- TDM-Guided Treatment With SSRIs in Hospitalized Adults and ChildrenRecruitingPhase 4Poznan University of Medical SciencesNCT07478796Written as Fluoxetine
- Fluoxetine and Understanding Social ExperiencesNot yet recruitingNot applicableUniversity of OxfordNCT07456501Written as Fluoxetine
- Fluoxetine on Emotional Experience (FLEX) StudyRecruitingNot applicableUniversity of OxfordNCT07424781Written as Fluoxetine
- Finding Treatments for COVID-19: A Trial of Antiviral Pharmacodynamics in Early Symptomatic COVID-19 (PLATCOV)RecruitingPhase 2University of OxfordNCT05041907Written as Fluoxetine
- Sequenced Treatment Alternatives to Relieve Adolescent Depression (STAR-AD)RecruitingPhase 1/2First Affiliated Hospital of Chongqing Medical UniversityNCT05814640Written as Fluoxetine
- The Friendship Bench Plus TrialRecruitingNot applicableUniversity of BernNCT06384209Written as Fluoxetine
- Disposition Kinetics of Dolutegravir Among People Living With HIV With Major Depression in NigeriaNot yet recruitingPhase 4University of IbadanNCT07110831Written as Fluoxetine
- Rapid Improvement of Depression of Fluoxetine Combined With ATPRecruitingPhase 2Nanfang Hospital, Southern Medical UniversityNCT05431413Written as Experimental group: Fluoxetine and ATP
- The Effects of Fluoxetine and/or DHEACompletedEarly Phase 1University of Maryland, BaltimoreNCT03228732Written as Fluoxetine
- Clinical Trials to Evaluate Metformin to Treat Depression in People Living With HIVWithdrawnPhase 2University of MinnesotaNCT07007221Written as Fluoxetine
- Improving Outcomes in Depression in Primary Care in a Low Resource SettingActive, not recruitingPhase 3Harvard Medical School (HMS and HSDM)NCT05944926Written as Antidepressant medication (fluoxetine)
See all 160 studies that test Fluoxetine →
Given beside what is tested · 16 — Fluoxetine is usual care or a partner of the new treatment
- Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder PatientsRecruitingPhase 3Tanta UniversityNCT06860958Written as Fluoxetine
- Dapagliflozin in DepressionRecruitingPhase 1/2Tanta UniversityNCT07239011Written as Fluoxetine
- Clinical Study to Evaluate the Possible Efficacy of Dapagliflozin and Atorvastatin in Patients With Major Depressive DisordersCompletedPhase 2Tanta UniversityNCT05792540Written as Fluoxetine 20 mg
- A Multicenter Clinical Study on Shuganjieyu Capsule Combined With Fluoxetine in the Treatment of DepressionCompletedNot applicablePeking UniversityNCT05361330Written as Fluoxetine
- Magnesium Supplementation With Fluoxetine for Cognitive Function in DepressionCompletedNot applicableHasanuddin UniversityNCT07521358Written as Fluoxetine (drug)
- Clinical Study on the Safety and Efficacy of Dental Pulp Mesenchymal Cells in the Treatment of DepressionStatus unknownNot applicableCAR-T (Shanghai) Biotechnology Co., Ltd.NCT05127369Written as fluoxetine hydrochloride capsule
- TDCS in Pediatric and Teenage Patients With Major Depressive Disorder During COVID-19 PandemicStatus unknownPhase 2/3El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco SuarezNCT04780152Written as Fluoxetine Tablets
- Effectiveness of Stepped Care Versus Best Available Care for Bulimia NervosaCompletedNot applicableUniversity of MinnesotaNCT00733525Written as Fluoxetine
- A Study of Olanzapine and Fluoxetine for Treatment-resistant DepressionTerminatedPhase 3Eli Lilly and CompanyNCT01687478Written as Fluoxetine
- Safety and Tolerability of Oral OPC-34712 as Adjunctive Therapy in Adults With Major Depressive Disorder (the Orion Trial)CompletedPhase 3Otsuka Pharmaceutical Development & Commercialization, Inc.NCT01360866Written as Fluoxetine
- Improving Sleep and Psychological Functioning in People With Depression and InsomniaCompletedPhase 4Wake Forest University Health SciencesNCT00247624Written as Fluoxetine
- Sequential Treatment of Pediatric MDD to Increase Remission and Prevent RelapseCompletedNot applicableUniversity of Texas Southwestern Medical CenterNCT00612313Written as Fluoxetine
- A Positron Emission Topographic (PET) Study on Depression Patient With ElectroacupunctureCompletedNot applicableThe University of Hong KongNCT01479920Written as Fluoxetine
- Combination of Antidepressants and Fingolimod Relapsing-remitting Multiple Sclerosis (RRMS) Patients With DepressionTerminatedPhase 4Novartis PharmaceuticalsNCT01436643Written as Fluoxetine
- Interpersonal Psychotherapy for Treatment Resistant DepressionStatus unknownNot applicableHospital de Clinicas de Porto AlegreNCT01896349Written as fluoxetine
- Electroacupuncture Combined With Antidepressants for Post-stroke DepressionCompletedNot applicableThe University of Hong KongNCT01174394Written as Fluoxetine
As the comparator · 25 — what is tested is compared with Fluoxetine
- Vortioxetine in the Elderly vs. Selective Serotonin Reuptake Inhibitors (SSRIs): a Pragmatic AssessmentCompletedPhase 4Azienda Ospedaliera Universitaria Integrata VeronaNCT03779789Written as Fluoxetine
- Active Reference (Fluoxetine) Fixed-dose Study of Vortioxetine in Paediatric Participants Aged 7 to 11 Years With Major Depressive Disorder (MDD)CompletedPhase 3H. Lundbeck A/SNCT02709655Written as Fluoxetine 20mg/day
- Comparison of Fluoxetine Versus Citalopram Therapy to Control Postmenopausal Vasomotor SyndromeCompletedNot applicableHospital Regional 1o de OctubreNCT05346445Written as Fluoxetine 20 MG
- Efficacy, Safety, and Tolerability of Levomilnacipran ER in Pediatric Patients (7-17 Years) With Major Depressive DisorderCompletedPhase 3AllerganNCT03569475Written as Fluoxetine
- Acupuncture for Ischemic Post-stroke DepressionCompletedNot applicableFirst Teaching Hospital of Tianjin University of Traditional Chinese MedicineNCT02472613Written as Fluoxetine
- Safety and Efficacy of Levomilnacipran ER in Adolescent Participants With Major Depressive DisorderCompletedPhase 3Forest LaboratoriesNCT02431806Written as Fluoxetine
- Active Reference (Fluoxetine) Fixed-dose Study of Vortioxetine in Paediatric Patients Aged 12 to 17 Years With Major Depressive Disorder (MDD)CompletedPhase 3H. Lundbeck A/SNCT02709746Written as Fluoxetine 20 mg/day
- The Activation on Prefrontal Cortex With Acupuncture and Moxibustion for Major Depressive Disorder: A Study of Functional Near Infrared SpectroscopyCompletedPhase 2Chengdu University of Traditional Chinese MedicineNCT04272476Written as Fluoxetine
- Safety and Efficacy of Vilazodone in Pediatric Patients With Major Depressive Disorder (VLZ-MD-22)CompletedPhase 3Forest LaboratoriesNCT02372799Written as Fluoxetine
- Randomized Clinical Trial of a Mindfulness Based Intervention in Generalized Anxiety DisorderCompletedNot applicableHospital de Clinicas de Porto AlegreNCT03072264Written as Fluoxetine
- Comparison of Acupuncture and Fluoxetine on Quality of Life in Menopausal WomenStatus unknownNot applicableGonabad University of Medical SciencesNCT02188225Written as fluoxetine
- A Study Of DVS SR In Treatment Of Children And Adolescent Outpatients With MDDCompletedPhase 3PfizerNCT01372150Written as fluoxetine
- Bupropion for Depression in ESRD Patients on HemodialysisTerminatedPhase 4University of ArkansasNCT02238977Written as Fluoxetine
- Comparison of Behavioral Activation and Antidepressant Medication in the Treatment of Adolescents With DepressionTerminatedNot applicableEmory UniversityNCT01740726Written as Fluoxetine
- A Study in the Treatment of Children and Adolescents With Major Depressive DisorderCompletedPhase 3Eli Lilly and CompanyNCT00849901Written as fluoxetine
- To Demonstrate the Relative Bioavailability of Fluoxetine Hydrochloride Capsules, 40 mgCompletedPhase 1SandozNCT00947076Written as Fluoxetine Hydrochloride Capsules, 40 mg (Prozac) (Eli Lilly)
- Deep Brain Stimulation of NAc/ALIC to Prevent Treatment-Refractory Obsessive Compulsive DisorderStatus unknownNot applicableTang-Du HospitalNCT02601677Written as Fluoxetine
- Magnetic Resonance Imaging Study of Cognitive-Behavior Therapy for Major Depressive DisorderStatus unknownPhase 4Nanjing Medical UniversityNCT01460212Written as SSRI antidepressants
- Cognitive Therapy for Recurrent DepressionCompletedPhase 3University of Texas Southwestern Medical CenterNCT00118404Written as Continuation phase fluoxetine
- Algorithm Guided Treatment Strategies for Major Depressive DisorderStatus unknownPhase 4Shanghai Mental Health CenterNCT01764867Written as Fluoxetine
Showing 20 of 25.
Codes
What other systems call Fluoxetine · ClinicalTrials.gg INT007512
- MeSH (NLM) D005473FluoxetineConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 01K63SUP8DFLUOXETINEConfirmed FDA, NLM, Wikidata
- RxNorm 4493Confirmed FDA, Wikidata
- Wikidata Q422244fluoxetineConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C506FluoxetineOne source FDA
- DrugBank DB00472One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D005473 | Fluoxetine | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 01K63SUP8D | FLUOXETINE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 4493 | — | Confirmed FDA, Wikidata |
| Wikidata | Q422244 | fluoxetine | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C506 | Fluoxetine | One source FDA |
| DrugBank | DB00472 | — | One source Wikidata |
Also registered as fluoxetine hydrochloride (UNII I9W7N6B1KJ · RxNorm 227224).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.