Premenstrual Syndrome clinical trials
The registry lists 177 studies for Premenstrual Syndrome across more than 10 countries. 32 are recruiting or about to start. 152 of them are mainly about Premenstrual Syndrome (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12. Counting its narrower condition Premenstrual Dysphoric Disorder too: 203 studies, 39 open.
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Status
Who runs them
Cairo University (15) · National Institute of Mental Health (NIMH) (5) · Riphah International University (5) · Saglik Bilimleri Universitesi (4) · Kırklareli University (4) · Wyeth is now a wholly owned subsidiary of Pfizer (3) · Eastern Mediterranean University (3) · Kutahya Health Sciences University (3)
What is being tested here
Drugs under test in Premenstrual Syndrome studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 9
- Nov 2026Dose-Response Effects of a 6-Week Progressive Resistance Training Program on Premenstrual Syndrome in Adolescent Girls · Riphah International University
- Dec 2026Self-Acupressure for Primary Dysmenorrhea and Premenstrual Symptoms · Nigde Omer Halisdemir University
- Jan 2027Integrated Core Stability Exercises and Yoga Program on Premenstrual Syndrome · Mansoura University
- Jan 2027A Clinical Trial to Evaluate the Effects of the Kaia Relief - Cycle System on Premenstrual Symptom Severity, Menstrual Discomfort, and Overall Well-Being in Premenopausal Women. · Vivance Group
- Jan 2027CREST: Samphire Guided Care Program on Wellbeing, Work Productivity, and Quality of Life · Samphire Group, Inc.
- Feb 2027THE EFFECT OF A REFLEXOLOGY PROGRAM ON PREMENSTRUAL SYNDROME SYMPTOMS, QUALİTY OF LİFE AND GENERAL COMFORT · Dokuz Eylul University
- May 2027The Effects of Manual Lymphatic Drainage and Self-Manual Lymphatic Drainage · Izmir Democracy University
- Jun 2027The Effect of Mandala Coloring, Sleep Quality, Anxiety With Premenstrual Syndrome · Kırklareli University
- Jul 2027Cohort Study of Honghua Xiaoyao Tablets in the Treatment of Premenstrual Syndrome Based on Target Trial Emulation Framework · Lianxin Wang
Who these studies take
Of the 11 Premenstrual Syndrome studies recruiting now, 0 (0%) set no upper age limit and 11 (100%) stop at 75 or younger. 0 (0%) take children under 18. 11 (100%) are for women only and 0 (0%) for men only; 9 (82%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 11 (100%) | 0 (0%) |
| 30 | 10 (91%) | 0 (0%) |
| 40 | 7 (64%) | 0 (0%) |
| 50 | 3 (27%) | 0 (0%) |
| 65 | 1 (9%) | 0 (0%) |
| 75 | 0 (0%) | 0 (0%) |
| 85 | 0 (0%) | 0 (0%) |
Across all 177 studies, recruiting or not: 81% stop at 75 or younger and 81% at 65; 8% take children; 97% are for women only and 0% for men only; 51% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Premenstrual Syndrome studies take
Of 87 interventional studies with no phase under Premenstrual Syndrome, half reached primary completion within 5 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 5 mo3–10 · 87 studies | — | 5 mo2–12 · 76 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 14, 2026.
Newly registered2
- Integrated Core Stability Exercises and Yoga Program on Premenstrual SyndromeOct 22, 2026NCT07889141
- A Clinical Trial to Evaluate the Effects of the Kaia Relief - Cycle System on Premenstrual Symptom Severity, Menstrual Discomfort, and Overall Well-Being in Premenopausal Women.Oct 15, 2026NCT07876050
Studies
Recruiting first, then most recently updated. Showing 50 of 177. Browse all 177 → or search them.
- Integrated Core Stability Exercises and Yoga Program on Premenstrual SyndromeNot yet recruitingNCT07889141Not applicable1 country
- A Clinical Trial to Evaluate the Effects of the Kaia Relief - Cycle System on Premenstrual Symptom Severity, Menstrual Discomfort, and Overall Well-Being in Premenopausal Women.RecruitingNCT07876050Not applicable1 country
- The Effects of Manual Lymphatic Drainage and Self-Manual Lymphatic DrainageNot yet recruitingNCT07814807Not applicable1 country
- THE EFFECT OF A REFLEXOLOGY PROGRAM ON PREMENSTRUAL SYNDROME SYMPTOMS, QUALİTY OF LİFE AND GENERAL COMFORTNot yet recruitingNCT07803497Not applicable
- The Effect of Mandala Coloring, Sleep Quality, Anxiety With Premenstrual SyndromeNot yet recruitingNCT07785622Not applicable1 country
- Self-Acupressure for Primary Dysmenorrhea and Premenstrual SymptomsRecruitingNCT07409337Not applicable1 country
- Menstrual Cycle Symptoms and Female HealthRecruitingNCT076992241 country
- Aerobic Exercises Versus Sub Occipital Myofascial Release on Memory Function in Females With Premenstrual Syndrome.Not yet recruitingNCT07684495Not applicable1 country
- CREST: Samphire Guided Care Program on Wellbeing, Work Productivity, and Quality of LifeRecruitingNCT076790741 country
- Effects of Somatic Movement Therapy vs Core Strengthening in Premenstrual SyndromeRecruitingNCT07642232Not applicable1 country
- Identification and Validation of Epigenetic Biomarkers of PMDDRecruitingNCT067715831 country
- Allopregnanolone and Dynamic GABA-A Receptor Plasticity in Selective Serotonin Reuptake Inhibitor Responsive Premenstrual Dysphoric DisorderRecruitingNCT06704594Phase 41 country
- Efficacy and Safety of Shatavari Root Extract for Premenstrual Syndrome in WomenNot yet recruitingNCT07441096Not applicable1 country
- Primary Dysmenorrhea and Comfort TheoryNot yet recruitingNCT07376759Not applicable
- Microdosing LSD in Women With Premenstrual DisordersNot yet recruitingNCT07189299Not applicable1 country
- Cohort Study of Honghua Xiaoyao Tablets in the Treatment of Premenstrual Syndrome Based on Target Trial Emulation FrameworkNot yet recruitingNCT07171814
- The Effect of Sensory Awareness Education on Female Students' Body Awareness and Premenstrual Symptom LevelsNot yet recruitingNCT07097181Not applicable1 country
- Moderate Aerobic Exercise for Managing Menstrual Cycle SymptomsRecruitingNCT07084714Not applicable1 country
- The Effect of Reflexology on Premenstrual Syndrome Symptoms, Pain and Quality of LifeNot yet recruitingNCT06961552Not applicable
- Effects of Yoga on Balance, Cognition, Posture, and Body Awareness in Premenstrual Syndrome (PMS)Enrolling by invitationNCT06785766Not applicable1 country
- Effect of Connective Tissue Massage on Premenstrual SyndromeNot yet recruitingNCT06621680Not applicable1 country
- Physical Activity in People With Borderline Personality Disorder (PABORD)Not yet recruitingNCT06461104Not applicable1 country
- The Effect of Su-Jok Application and Progressive Muscle Relaxation Exercises in Coping With Premenstrual SyndromeRecruitingNCT06296043Not applicable1 country
- Effect of Online Exercises for Premenstrual Syndrome on Couple's Stress and Family FunctionNot yet recruitingNCT06370429Not applicable1 country
- Premenstrual Syndrome and Laughter YogaNot yet recruitingNCT06382090Not applicable
- Progressive Muscle Relaxation Exercises on Premenstrual SyndromeNot yet recruitingNCT06208670Not applicable1 country
- Effects of Training Given to Cope With Premenstrual Syndrome and Mandala Activity on Premenstrual SymptomsRecruitingNCT06176313Not applicable1 country
- A Multidimensional Study of Premenstrual Syndrome and Body ImageRecruitingNCT061466731 country
- Prevalence of Premenstrual Syndrome in Women of Reproductive AgeNot yet recruitingNCT061172151 country
- The Relationship of Premenstrual Syndrome and Primary Dysmenorrhea With Severity of Temporomandibular DisordersNot yet recruitingNCT06052722Not applicable1 country
- The Effect of Laughter Yoga on Premenstrual Symptoms and Quality of Life in Midwifery StudentsNot yet recruitingNCT05859399Not applicable
- Effect of Sage Essential Oil Inhalation Aromatherapy on Premenstrual Symptoms and Quality of LifeNot yet recruitingNCT05823207Not applicable
- Study of Premenstrual Syndrome and Premenstrual DysphoriaCompletedNCT000011771 country
- THE EFFECT OF GUİDED IMAGERY ON PREMENSTRUAL SYNDROMECompletedNCT07202650Not applicable1 country
- The Efficacy of Lavender Herbal Tea in Premenstrual SyndromeCompletedNCT07737366Not applicable1 country
- The Effect of Progressive Muscle Relaxation Exercises on Premenstrual Syndrome, Anxiety, and Tendency to Violence in Young WomenCompletedNCT06909955Not applicable1 country
- Dose-Response Effects of a 6-Week Progressive Resistance Training Program on Premenstrual Syndrome in Adolescent GirlsActive, not recruitingNCT07754149Not applicable1 country
- Dual-Task Postural Stability in Women With Premstrual Syndrome: A Within-Subject Comparative StudyCompletedNCT078016511 country
- Effects of Foot Bath Therapy on Premenstrual Syndrome Symptoms, Quality of Life, and PainCompletedNCT07461051Not applicable1 country
- Effect of Health Belief Model-Based Peer Education on Premenstrual SyndromeCompletedNCT07789626Not applicable1 country
- Progressive Muscle Relaxation and Kinesio Taping for Premenstrual SyndromeCompletedNCT07791121Not applicable1 country
- A Clinical Study to Assess the Effect of a Dietary Supplement on Menstrual Cycle SymptomsCompletedNCT07267728Not applicable1 country
- Effect of Electroacupuncture on Premenstrual Syndrome in Young WomenCompletedNCT07737210Not applicable1 country
- Self-Compassion and Quality of Life in Nursing Students With Premenstrual SyndromeCompletedNCT076846381 country
- Mandala and Music for PMS ReliefCompletedNCT07097558Not applicable1 country
- Effects of Seed Cycling Capsules on Premenstrual Syndrome Symptoms and Menstrual Cycle LengthCompletedNCT07655466Not applicable1 country
- Efficacy of a Food Supplement in Relieving Premenstrual Syndrome SymptomsCompletedNCT07013539Not applicable1 country
- Health Belief Model-Based Podcast Education for Premenstrual Symptoms in University StudentsCompletedNCT07646769Not applicable1 country
- Auricular Acupressure for Premenstrual Syndrome in Female StudentsCompletedNCT06981533Not applicable1 country
- Laughter Yoga and Sleep Hygiene Training for College Students With Premenstrual SyndromeCompletedNCT07599436Not applicable1 country