Ischemic Stroke clinical trials
The registry lists 2,612 studies for Ischemic Stroke across more than 10 countries. 971 are recruiting or about to start. 2,117 of them are mainly about Ischemic Stroke (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 3 narrower conditions too, such as Embolic Stroke: 2,654 studies, 982 open.
ClinicalTrials.gov finds 4,080 studies for Ischemic Stroke. How that becomes 2,611 here
This page counts the studies the registry files under Ischemic Stroke, and those it files under no condition that list Ischemic Strokethemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 4,080Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −37Filed under a narrower condition, counted on its own pageStroke, Lacunar 14 · Embolic Stroke 14 · Thrombotic Stroke 9
- −30List Ischemic Stroke as a condition, but the registry did not file them under itMost often written as “Acute Ischaemic Stroke” (5), “Acute Ischemic Stroke AIS” (5), and “Hemiplegia Following Ischemic Stroke” (4). The registry filed them under other conditions only, most often Stroke (18) and Ischemic Attack, Transient (5).
- −1,402Match it another way412 name it in the title, 16 in a keyword, and 974 by a synonym or other text the search reads.
- 2,611The count on this page42 of them list Ischemic Stroke in their own words; the registry filed them under no condition.
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· Enrollment: 300 → 450 participants
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Status
Who runs them
Beijing Tiantan Hospital (85) · Xuanwu Hospital, Beijing (52) · Capital Medical University (45) · General Hospital of Shenyang Military Region (34) · Second Affiliated Hospital, School of Medicine, Zhejiang University (28) · Kafrelsheikh University (21) · Assistance Publique - Hôpitaux de Paris (20) · Yi Yang (20)
What is being tested here
Drugs under test in Ischemic Stroke studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Tenecteplase | 29 | 40 | 56 |
| Tirofiban | 13 | 13 | 21 |
| Cilostazol | 8 | 10 | 17 |
| Ticagrelor | 8 | 14 | 15 |
| Atorvastatin | 6 | 4 | 9 |
| Aspirin | 5 | 4 | 22 |
| Clopidogrel | 5 | 9 | 18 |
| Cerebrolysin | 5 | 4 | 12 |
| Butylphthalide | 5 | 4 | 9 |
| Tissue Plasminogen Activator | 4 | 12 | 25 |
Drug classes tested here Thrombolytics 38 open · P2Y12 inhibitors 11 open · Statins 10 open · Factor Xa inhibitors 10 open · GLP-1 receptor agonists 6 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Nov 2026Remote Ischemic Conditioning for Acute Ischemic Stroke Treated With Mechanical Thrombectomy(RECAST-MT) · Phase 3 · Capital Medical University
- Nov 2026Regular Physical Exercise in Patients With Symptomatic Intracranial Arterial Stenosis · Phase 3 · Capital Medical University
- Nov 2026UCMSCs as Treatment for Patients With Acute Ischemic Stroke (Stroke Neuroncell-EX) · Phase 3 · Cytopeutics Sdn. Bhd.
- Dec 2026Treatment of Acute Ischemic Stroke (ReMEDy2 Trial) · Phase 3 · DiaMedica Therapeutics Inc
- Dec 2026Efficacy and Safety of Tenecteplase Bridging Mechanical Thrombectomy for Acute Large Vessel Occlusion Stroke · Phase 3 · Xuanwu Hospital, Beijing
- Dec 2026Quelling of Excitotoxicity in Acute Stroke With Ketamine · Phase 3 · Lower Merion Neurology Research Foundation
- Dec 2026Intravenous Thrombolysis and NOAC · Phase 3 · Second Affiliated Hospital, School of Medicine, Zhejiang University
- Jan 2027Intravenous Tirofiban After Bridging Therapy for Acute Stroke With Atherosclerotic Large Artery Occlusion · Phase 3 · Beijing Tiantan Hospital
- Feb 2027Tenecteplase Reperfusion Therapy in Acute Ischemic Cerebrovascular Events-BEYOND · Phase 3 · Beijing Tiantan Hospital
- Mar 2027Early Aggressive Strategy for Treatment of Lipid-Lowering in Acute Ischemic Stroke Delivered With Endovascular Therapy for Large Artery Occlusion · Phase 3 · Shanghai East Hospital
Who these studies take
Of the 655 Ischemic Stroke studies recruiting now, 394 (60%) set no upper age limit and 62 (9%) stop at 75 or younger. 26 (4%) take children under 18. 1 (<1%) are for women only and 1 (<1%) for men only; 41 (6%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 22 (3%) | 22 (3%) |
| 18 | 557 (85%) | 557 (85%) |
| 30 | 599 (91%) | 599 (91%) |
| 40 | 627 (96%) | 627 (96%) |
| 50 | 634 (97%) | 634 (97%) |
| 65 | 638 (97%) | 638 (97%) |
| 75 | 624 (95%) | 624 (95%) |
| 85 | 473 (72%) | 472 (72%) |
Across all 2,612 studies, recruiting or not: 11% stop at 75 or younger and 4% at 65; 5% take children; <1% are for women only and <1% for men only; 7% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Ischemic Stroke studies take
Of 165 phase 3 interventional studies under Ischemic Stroke, half reached primary completion within 30 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 15 mo7–29 · 42 studies | — | — |
| Phase 1/2 | 30 mo20–76 · 27 studies | — | — |
| Phase 2 | 28 mo15–39 · 124 studies | 24 mo12–35 · 41 studies | 28 mo15–40 · 83 studies |
| Phase 2/3 | 31 mo26–55 · 30 studies | — | — |
| Phase 3 | 30 mo19–52 · 165 studies | — | 32 mo20–62 · 143 studies |
| Phase 4 | 31 mo24–41 · 83 studies | — | 31 mo24–41 · 74 studies |
| Interventional, no phase | 27 mo14–48 · 653 studies | 24 mo14–46 · 81 studies | 28 mo14–48 · 572 studies |
| Observational | 53 mo24–127 · 436 studies | 26 mo17–50 · 42 studies | 56 mo25–140 · 394 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Started recruiting16
- Randomized a Clinical Trial With Medical Device in Acute Ischemic StrokeNov 10, 2026NCT07113184
- Prevention of Ischemic Stroke Recurrence Using Digital Technology ApplicationNov 10, 2026NCT07825311
- Short-Term External Trigeminal Nerve Stimulation for Acute Ischemic StrokeNov 10, 2026NCT07911605
- Tenecteplase for Late-Window Stroke Guided by DWI-FLAIR MismatchNov 9, 2026NCT07540416
- Association of Prophylactic Use of Stress Ulcer Drugs and Clinical Outcomes in Patients With Acute Anterior Circulation ThrombectomyNov 5, 2026NCT05845372
Show 11 moreShow fewer
- The Efficacy and Safety of HRS-4029 in Acute Ischemic Stroke PatientsNov 5, 2026NCT07739160
- SAIL-MEVO: Endovascular Treatment Versus Best Medical Therapy for Distal Vessel OcclusionsNov 4, 2026NCT07843797
- Vagus Nerve Stimulation on Improving Sleep in Inpatient Rehab for Post-Acute StrokeNov 4, 2026NCT07858656
- Connectomic Alterations Following Acute Ischemic Stroke in the MCA TerritoryOct 30, 2026NCT07584681
- Role of Hypothermia in Endovascular Stroke ThrombectomyOct 29, 2026NCT06109376
- Rapid Local Ischemic Postconditioning on Stroke After ThrombectomyOct 28, 2026NCT07598799
- Testing a New Treatment Strategy to Improve Secondary Stroke Prevention for Older Adults: The STROKE75+ TrialOct 23, 2026NCT07454707
- Tenecteplase or Reteplase as Bridging Thrombolysis Before Thrombectomy in Acute Ischemic Cerebrovascular EventsOct 22, 2026NCT07748039
- ACT-GLOBAL IA Thrombolysis(ACT-REACT-004)Domain Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632Oct 21, 2026NCT07687056
- Advancing Reperfusion Therapy for Ischemic Stroke: Safety and Efficacy of Anakinra for Futile Reperfusion Following Endovascular Treatment in Patients With Acute Ischemic StrokeOct 16, 2026NCT07423975
- Endovascular Therapy for Acute Basilar Artery Occlusion With Large Ischemic CoreOct 13, 2026NCT07672795
Results posted1
Stopped1
- Blood PREssure Augmentation in Large-vessel Occlusion Stroke StudyTerminatedOct 14, 2026NCT04218773
Newly registered37
- AI-Based Tools for Stroke Diagnosis, Treatment and Outcome Prediction: a Multicentre Prospective Observational StudyNov 9, 2026NCT07924371
- Biomarkers of Paired VNSNov 6, 2026NCT07922200
- Proof-of-concept for Use of Transcutaneous Spinal Stimulation (TSS) With the ExaStim® Stimulation System in Adults With Chronic Ischemic StrokeNov 4, 2026NCT07917221
- Short-Term External Trigeminal Nerve Stimulation for Acute Ischemic StrokeNov 3, 2026NCT07911605
- Dynamic Stabilometry Combined With Transcranial Direct Current Stimulation for Balance and Motor Recovery After Ischemic StrokeNov 3, 2026NCT07912151
Show 32 moreShow fewer
- Tenecteplase Bridging Thrombolysis Prior to Inter-hospital Transfer for Endovascular Therapy in Anterior Circulation Large Vessel Occlusion Stroke Within 4.5-24 HoursNov 3, 2026NCT07912970
- ARTEMIS: UC-MSCs After Mechanical Thrombectomy for Acute Ischemic StrokeNov 3, 2026NCT07913282
- Integrating Wearable Monitoring and Clinical Data for Stroke Early WarningNov 2, 2026NCT07908303
- Upfront Lipid-Lowering Therapy With Statins Combined With Hybutimibe in Patients With Acute Ischemic Stroke or Transient Ischemic Attack.Nov 2, 2026NCT07908875
- Accelerated Theta-Burst Stimulation for Refractory Central Post-Stroke PainNov 2, 2026NCT07909954
- Brain-Machine Interface With Virtual Reality and Neuromuscular Electrical Stimulation for Upper Limb Rehabilitation After StrokeNov 2, 2026NCT07911384
- INTRA-ARTERIAL MeVO TREATMENT (IMP-ACT) Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632Oct 30, 2026NCT07906275
- Sevoflurane vs. Propofol for General Anesthesia in Patients With Acute Ischemic Stroke Treated With Endovascular TherapyOct 29, 2026NCT07902791
- Safety of NRICM301 Added to Standard Care in Adults With Acute Ischemic StrokeOct 29, 2026NCT07902934
- Continuous Blood Pressure Variability and Small Vessel Disease in Acute Ischemic StrokeOct 29, 2026NCT07903922
- Safety and Feasibility of NRICM301 Added to Usual Care for Adults With Acute Ischemic StrokeOct 28, 2026NCT07900503
- Recombinant Human Prourokinase for Acute Ischemic Stroke in the Extended Window Selected by CT-Based Artificial IntelligenceOct 28, 2026NCT07901842
- Temporal Interference Stimulation for Upper-Limb Motor Recovery in Early Subacute StrokeOct 27, 2026NCT07896629
- Selective Intra-Arterial Hypothermia After Endovascular Treatment for Acute Basilar Artery OcclusionOct 27, 2026NCT07896655
- Cardiac CT Angiography in Acute Stroke Imaging (SCOPE-CT)Oct 27, 2026NCT07896889
- Safety and Efficacy of CG-BM1 in Ischemic StrokeOct 27, 2026NCT07896941
- Detecting and Predicting Post-stroke Cognitive Impairment Using the Oxford Cognitive ScreenOct 27, 2026NCT07897916
- Tenecteplase in Acute Ischemic Stroke Under Different Transfer ModelsOct 27, 2026NCT07897955
- Metformin in Acute Ischemic StrokeOct 27, 2026NCT07899307
- Neurological Rehabilitation and Neuroplasticity After Ischemic StrokeOct 27, 2026NCT07899710
- Development and Validation of Risk Prediction Models for Stroke and Cognitive Impairment in Moyamoya Disease and Moyamoya SyndromeOct 26, 2026NCT07894107
- EEG Feedback-Based Vagus Nerve Stimulation for Post-Stroke DysphagiaOct 26, 2026NCT07894315
- Clinical Outcomes of Stroke in MalIgnanCyOct 26, 2026NCT07895173
- Prehospital Response and Emergency Stroke Transport OptimisationOct 23, 2026NCT07892053
- A Study to Evaluate the Intracranial Arterial Recanalization With Multiple Doses of LT3001 Drug Product in AIS ParticipantOct 22, 2026NCT07890298
- Early Administration of Angong Niuhuang Pill for Disabling Acute Ischemic Stroke (EAGER Trial)Oct 20, 2026NCT07882030
- Clinical Significance of Internal Carotid Artery DolichoarteriopathyOct 20, 2026NCT07882875
- Adenosine A2a Receptor-Mediated Neuroinflammation in Remote Ischemic Conditioning for Post-Stroke Sleep DisordersOct 15, 2026NCT07874594
- A Study to Evaluate Cenvacibart (REGN7508) for Secondary Stroke Prevention in Adult ParticipantsOct 15, 2026NCT07876492
- MSC Secretome and rTMS for Motor Recovery After Subacute Ischemic StrokeOct 14, 2026NCT07874269
- Carotid Plaque RADS vs CPVH: Diagnostic Accuracy ComparisonOct 13, 2026NCT07870512
- Infarct Growth After Intravenous Tocilizumab in Adults With Acute Ischemic Stroke Undergoing Endovascular Thrombectomy - ILLUMINATEOct 13, 2026NCT07870681
Studies
Recruiting first, then most recently updated. Showing 50 of 2,612. Browse all 2,612 → or search them.
- Short-Term External Trigeminal Nerve Stimulation for Acute Ischemic StrokeRecruitingNCT07911605Not applicable1 country
- ACT-GLOBAL Adaptive Platform Trial for StrokeRecruitingNCT06352632Phase 32 countries
- Randomized a Clinical Trial With Medical Device in Acute Ischemic StrokeRecruitingNCT07113184Not applicable1 country
- Stroke and Systemic Embolism Prevention in Adult Participants With Atrial Fibrillation for Whom Oral Anticoagulation is UnsuitableRecruitingNCT07430956Phase 32 countries
- A Study to Test if Tenecteplase Helps People to Recover From an Acute Stroke When Given More Than 4.5 Hours After the Person Was Last Seen WellRecruitingNCT07361302Phase 316 countries
- Prevention of Ischemic Stroke Recurrence Using Digital Technology ApplicationRecruitingNCT07825311Not applicable1 country
- INtra-arterial AltEplase folloWing successfuL reperfusIoN After mEchanical ThrombectomyRecruitingNCT07727395Phase 31 country
- Remote Ischemic Conditioning for Acute Ischemic Stroke Treated With Mechanical Thrombectomy(RECAST-MT)RecruitingNCT06559241Phase 31 country
- AI-Based Tools for Stroke Diagnosis, Treatment and Outcome Prediction: a Multicentre Prospective Observational StudyRecruitingNCT079243716 countries
- Ultra-early Identification of Futile Recanalization After Reperfusion Therapy in Acute Ischemic Stroke Based on Cerebral Autoregulation MonitoringRecruitingNCT07747701Not applicable1 country
- Tenecteplase for Late-Window Stroke Guided by DWI-FLAIR MismatchRecruitingNCT07540416Phase 31 country
- Thrombo-inflammation Biomarkers Trial in Acute Cerebral HypoxiaRecruitingNCT049715641 country
- A Multicenter, Open-label, Randomized, Non-inferiority Clinical Trial With Blinded Endpoint Assessment of Early Tirofiban After Intravenous Thrombolysis in Acute Ischemic StrokeNot yet recruitingNCT07842185Phase 2/31 country
- Early Closure of Left Atrial Appendage for Patients With Atrial Fibrillation and Ischemic Stroke Despite Anticoagulation TherapyRecruitingNCT05976685Not applicable6 countries
- A Phase II/III Clinical Study of SIM0811 in the Treatment of Acute Ischemic StrokeNot yet recruitingNCT07903701Phase 2/3
- Continuous Dual Aspiration Technique With Zoom System for StrokeRecruitingNCT074919521 country
- Selective Intra-Arterial Hypothermia After Endovascular Treatment for Acute Basilar Artery OcclusionNot yet recruitingNCT07896655Not applicable1 country
- Biomarkers of Paired VNSRecruitingNCT07922200Not applicable1 country
- Temporal Interference Stimulation for Upper-Limb Motor Recovery in Early Subacute StrokeNot yet recruitingNCT07896629Not applicable1 country
- Role of EEG in Differentiation Between Ischemic and Hemorrhagic StrokeRecruitingNCT069849651 country
- Effectiveness of Theta Burst Stimulation For Upper and Lower Extremity Recovery in StrokeRecruitingNCT07834333Not applicable1 country
- Association of Prophylactic Use of Stress Ulcer Drugs and Clinical Outcomes in Patients With Acute Anterior Circulation ThrombectomyRecruitingNCT058453721 country
- A Pivotal Study Evaluating Safety and Effectiveness of Adaptative Tip Catheter in Patients With Acute Ischemic StrokeRecruitingNCT07367100Not applicable4 countries
- The Efficacy and Safety of HRS-4029 in Acute Ischemic Stroke PatientsRecruitingNCT07739160Phase 21 country
- Efficacy and Safety Evaluation of iNstroke 5F Aspiration Catheter for ThrombectomyNot yet recruitingNCT07571954Not applicable2 countries
- Vagus Nerve Stimulation on Improving Sleep in Inpatient Rehab for Post-Acute StrokeRecruitingNCT07858656Not applicable1 country
- Hand and Arm Motor Recovery Via Non-invasive Electrical Spinal Cord Stimulation After StrokeRecruitingNCT05591196Not applicable1 country
- Discontinuation of Antithrombotic Treatment Following Patent Foramen Ovale Closure in Young Patients With Cryptogenic StrokeRecruitingNCT04475510Not applicable1 country
- SAIL-MEVO: Endovascular Treatment Versus Best Medical Therapy for Distal Vessel OcclusionsRecruitingNCT07843797Not applicable1 country
- Thrombolysis in Factor Xa-inhibitors TrialRecruitingNCT06878066Phase 33 countries
- Proof-of-concept for Use of Transcutaneous Spinal Stimulation (TSS) With the ExaStim® Stimulation System in Adults With Chronic Ischemic StrokeNot yet recruitingNCT07917221Not applicable1 country
- Upfront Lipid-Lowering Therapy With Statins Combined With Hybutimibe in Patients With Acute Ischemic Stroke or Transient Ischemic Attack.Not yet recruitingNCT07908875Phase 3
- Integrating Wearable Monitoring and Clinical Data for Stroke Early WarningNot yet recruitingNCT079083031 country
- Evaluation of iNstroke Aspiration Catheters for Thrombectomy: a Multi-center Prospective StudyNot yet recruitingNCT07376447Not applicable2 countries
- Efficacy and Safety of Interleukin-6 Receptor Inhibitor Combined With Endovascular Treatment in Patients With Acute Posterior Circulation Large Vessel Occlusion StrokeRecruitingNCT07509645Phase 31 country
- The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial FibrillationRecruitingNCT05836987Phase 31 country
- Tenecteplase Bridging Thrombolysis Prior to Inter-hospital Transfer for Endovascular Therapy in Anterior Circulation Large Vessel Occlusion Stroke Within 4.5-24 HoursNot yet recruitingNCT07912970Phase 31 country
- ARTEMIS: UC-MSCs After Mechanical Thrombectomy for Acute Ischemic StrokeNot yet recruitingNCT07913282Phase 11 country
- Dynamic Stabilometry Combined With Transcranial Direct Current Stimulation for Balance and Motor Recovery After Ischemic StrokeNot yet recruitingNCT07912151Not applicable1 country
- Accelerated Theta-Burst Stimulation for Refractory Central Post-Stroke PainNot yet recruitingNCT07909954Not applicable
- Brain-Machine Interface With Virtual Reality and Neuromuscular Electrical Stimulation for Upper Limb Rehabilitation After StrokeNot yet recruitingNCT07911384Not applicable1 country
- Detecting and Predicting Post-stroke Cognitive Impairment Using the Oxford Cognitive ScreenNot yet recruitingNCT078979161 country
- Probucol for Symptomatic Intracranial and Extracranial Artery StenosisRecruitingNCT06225752Phase 31 country
- Connectomic Alterations Following Acute Ischemic Stroke in the MCA TerritoryRecruitingNCT07584681Not applicable1 country
- INTRA-ARTERIAL MeVO TREATMENT (IMP-ACT) Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632Not yet recruitingNCT07906275Phase 31 country
- Anti-inflammatory and Anti-thrombotic Therapy With colcHicine and Low Dose Rivaroxaban for Major Adverse Cardiovascular Events Reduction in Ischemic StrokeNot yet recruitingNCT06396858Phase 4
- Role of Hypothermia in Endovascular Stroke ThrombectomyRecruitingNCT06109376Not applicable1 country
- Treatment of Acute Ischemic Stroke With Edaravone Dexborneol Sublingual Tablets in Small Vessel DiseaseRecruitingNCT06674460Phase 31 country
- Continuous Blood Pressure Variability and Small Vessel Disease in Acute Ischemic StrokeNot yet recruitingNCT079039221 country
- Safety of NRICM301 Added to Standard Care in Adults With Acute Ischemic StrokeNot yet recruitingNCT07902934Not applicable