Drug
Nalbuphine clinical trials
Also written Nubain.
Keep track of what changes. Save the Nalbuphine studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
85 studies that test it; most in 2025 (12)
| Year | Studies |
|---|---|
| 2000 | 1 |
| 2004 | 1 |
| 2005 | 1 |
| 2008 | 2 |
| 2010 | 2 |
| 2013 | 1 |
| 2014 | 2 |
| 2015 | 5 |
| 2016 | 4 |
| 2017 | 2 |
| 2018 | 11 |
| 2019 | 7 |
| 2020 | 1 |
| 2021 | 5 |
| 2022 | 3 |
| 2023 | 7 |
| 2024 | 8 |
| 2025 | 12 |
| 2026 | 10 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 20 · Other 65
Trevi Therapeutics (17) · Assiut University (15) · Ain Shams University (5) · Sun Yat-sen University (2) · Cairo University (2) · University of California, San Francisco (2) · Liaquat National Hospital & Medical College (1) · CMH Lahore Medical College and Institute of Dentistry (1)
Often tested with
Tested in the same studies.
Dexmedetomidine (11) · Morphine (6) · Fentanyl (6) · Bupivacaine (4) · Spinal Block (2) · Sufentanil (2) · Flurbiprofen axetil (2) · Naloxone (2)
Related medicines
As reviewed, each with the page that says it.
- One of Analgesics, Opioid source
Studies
Open first, then newest update. How each study uses Nalbuphine is read from its arms, and is right about nine times in ten.
Testing it · 85
- The Effect of Nalbuphine Extended-Release (NAL ER) on Cough in Participants With Refractory Chronic Cough (RCC)RecruitingPhase 2Trevi TherapeuticsNCT07671924Written as NAL ER
- Idiopathic Pulmonary Fibrosis (IPF)-Related Chronic Cough Reduction With Nalbuphine Extended-Release (NAL ER) TabletsRecruitingPhase 3Trevi TherapeuticsNCT07671911Written as NAL ER
- Idiopathic Pulmonary Fibrosis (IPF)-Related Chronic Cough Reduction With Nalbuphine (NAL) Extended-Release (ER) TabletsRecruitingPhase 3Trevi TherapeuticsNCT07868419Written as NAL ER
- Ultrasound-Guided Ilioinguinal-Iliohypogastric Nerve Block Following Spinal Anesthesia Comparing Dexmedetomidine Versus Nalbuphine as Adjuvants to Bupivacaine in Unilateral Inguinal Hernia RepairNot yet recruitingPhase 4Assiut UniversityNCT07837492Written as Nalbuphine
- Analgesic Efficacy of Fascia Iliaca Compartment Block Compared With Intrathecal Nalbuphine for Hip Surgery Under Spinal AnesthesiaRecruitingNot applicableAin Shams UniversityNCT06818396Written as Intrathecal nalbuphine and spinal anesthesia
- Exploring the Impact of Genetic Variations on The Clinical Efficacy of Nalbuphine in Postoperative Pain ManagementRecruitingPhase 2/3Dr. Asma Abdus SalamNCT06996561Written as Nalbuphine Injection
- Effect of Nalbuphine Versus Fentanyl on Hemdoynamic Effects of LaryngoscopyRecruitingPhase 4Rawalpindi Institute of CardiologyNCT07435337Written as Nalbuphine
- Intravenous Nalbuphine Versus Lidocaine for Prevention of Propofol Injection PainNot yet recruitingNot applicableHayatabad Medical ComplexNCT07422558Written as Nalbuphine
- Analgosedation With Ketamine, Nalbuphine, or Dexmedetomidine for Suture Removal in Children After Cleft SurgeryRecruitingNot applicableUniversity Medical Centre LjubljanaNCT07340008Written as Nalbuphine
- Ultrasound-Guided Infraclvicular Block Using Dexmedetomidine Versus Nalbuphine as Adjuvants to Bupivacaine in Upper Limb Orthopedic SurgeryNot yet recruitingPhase 1Assiut UniversityNCT07279727Written as Nalbuphine
- Nalbuphine Timing Effects on Hemodynamics and Analgesia in Elderly PatientsRecruitingPhase 4Qianfoshan HospitalNCT07271849Written as Nalbuphine Hydrochloride injection was administered during anesthesia induction.
- Nalbuphine Versus Tramadol on Post Operative Analgesia in Abdominal Surgery on Pediatric Cancer PatientRecruitingNot applicableNational Cancer Institute, EgyptNCT07110051Written as Nalbuphine
- Nalbuphine Dosing and Its Impact on Anxiety and Depression in Ectopic Pregnancy SurgeryNot yet recruitingNot applicableChengdu Jinjiang Maternity and Child Health HospitalNCT07009808Written as Nalbuphine 0.20mg/ml(total 30 mg)
- The Evaluation of the Effectiveness and Safety of Nalbuphine Hydrochloride Injection for Analgesia in ICU Patients: A Multicenter, Randomized, Single-blinded, Parallel, Two-step TrialRecruitingPhase 2/3Wuhan Union Hospital, ChinaNCT06785571Written as Nalbuphine hydrochloride injection
- Comparative Study of Opioid-Free Anesthesia Versus Opioid Anesthesia in Patients Undergoing Laparoscopic CholecystectomyNot yet recruitingPhase 4Assiut UniversityNCT06736496Written as Nalbuphine
- Comparison of the Efficacy of Intraperitoneal Instillation of Fentanyl Versus Nalbuphine As Adjuvants to Bupivacaine for Postoperative Pain Relief in Patients Undergoing Laparoscopic CholecystectomyNot yet recruitingPhase 4Assiut UniversityNCT06722963Written as Nalbuphine
- Comparsion Between Intrathecal Fentanyl and Intravenous Nalbuphine As a Postoperative Analgesia in Lower Limb SurgeriesNot yet recruitingPhase 4Assiut UniversityNCT06720506Written as Nalbuphine
- Dexmedetomidine and Nalbuphine as Analgesic Adjuvants to Bupivacaine in Superficial Cervical Block.Not yet recruitingPhase 4Kasr El Aini HospitalNCT06490614Written as Nalbuphine in superficial cervical plexus block
- Nalbuphine in ARDS Patients After SurgeryRecruitingPhase 4Hairong ChenNCT06037330Written as Nalbuphine
- Sedation in Patients Undergoing GIT EndoscopyNot yet recruitingEarly Phase 1Assiut UniversityNCT05880459Written as propofol and magnesium sulphate ,propofol and nalbuphine
See all 85 studies that test Nalbuphine →
Given in every arm · 5 — Nalbuphine is usual care beside what is tested
- Ultrasound Guided Pecs Block and Ketamine Infusion for Preventing Chronic Pain in Patients Undergoing Breast Cancer SurgeryNot yet recruitingNot applicableAga Khan UniversityNCT07197684Written as Nalbuphine
- Nalbuphine With Remimazolam Versus Nalbuphine With Propofol for Knee ArthroscopyCompletedPhase 4Wuhan Fourth HospitalNCT07838948Written as Nalbuphine
- Non-anesthesiologist-administered Propofol During the Flexible BronchoscopyCompletedNot applicableHospital Universitario Dr. Jose E. GonzalezNCT02820051Written as Nalbuphine
- Conscious Sedation for Cataract Operations Under Topical AnaesthesiaCompletedPhase 2Menoufia UniversityNCT03933280Written as Nalbuphine
- Diclofenac Premedication, as the Effect of Preemptive Analgesia After Post-thoracotomy Chest and Shoulder PainCompletedPhase 4University of DebrecenNCT02445599Written as Nalbuphine
As the comparator · 5 — what is tested is compared with Nalbuphine
- Efficacy and Safety of Anrikefon for Postoperative Analgesia in Ophthalmic SurgeryRecruitingPhase 4Zhongshan Ophthalmic Center, Sun Yat-sen UniversityNCT07269106Written as Nalbuphine
- A Bioavailability Study of NALDEBAIN ER Injection and Nalbuphine Injection in Healthy Volunteers.CompletedPhase 1Lumosa Therapeutics Co., Ltd.NCT04256434Written as Nalbuphine HCl
- Erector Spinae Plane Block Versus Opioid Based General Anesthesia During Laparoscopic Bariatric SurgeryCompletedNot applicableCairo UniversityNCT03798522Written as Nalbuphine
- Intrathecal Nalbuphine Versus Midazolam in Cesarean SectionCompletedPhase 1Zagazig UniversityNCT03918187Written as Nalbuphine
- Herb Drug Interaction of Traditional Chinese Herb and Commonly Used DrugsStatus unknownPhase 1Tri-Service General HospitalNCT00923000Written as Nalbuphine
Codes
What other systems call Nalbuphine · ClinicalTrials.gg INT007865
- MeSH (NLM) D009266NalbuphineConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) L2T84IQI2KNALBUPHINEConfirmed FDA, NLM, Wikidata
- RxNorm 7238Confirmed FDA, Wikidata
- Wikidata Q277979nalbuphineConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C61854NalbuphineOne source FDA
- DrugBank DB00844One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D009266 | Nalbuphine | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | L2T84IQI2K | NALBUPHINE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 7238 | — | Confirmed FDA, Wikidata |
| Wikidata | Q277979 | nalbuphine | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C61854 | Nalbuphine | One source FDA |
| DrugBank | DB00844 | — | One source Wikidata |
Also registered as nalbuphine hydrochloride (UNII ZU4275277R · RxNorm 154985).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.