An observational study in Medication Abuse, Harm Reduction and Opioid Use Disorder, sponsored by University of Colorado, Denver. Not yet recruiting. Open to participants aged 12 Years to 89 Years. Per ClinicalTrials.gov, last updated 2026-09-30.
Sponsored by University of Colorado, Denver · Observational
The 2022 Center for Disease Control and Prevention (CDC) clinical practice guideline for prescribing opioids for pain recommends that when tapering a patient's opioid dose, doses should be decreased at a slow rate to reduce the risk of withdrawal symptoms, overdose, and to promote tolerance of the tapering. This project will examine the state of tapering in primary care across the system as well as conduct stakeholder interviews to understand the resources available across the system to support providers in tapering and identify opportunities for clinical decision support to be implemented to support guideline concordant tapering. Utilization of a clinical care pathway that gives providers information, recommendations, and educational material on strategies for opioid tapering will be examined. The rate of opioid tapering in line with CDC guidelines will be examined as well as long term patient outcomes of opioid overdose of poisoning using existing patient health records. The study period will be approximately 8 months.
70 studies on the registry are indexed under Opiate Overdose; 11 are open to participants now.
This study's planned enrollment of 200,000 is above the median of 284 across 16 observational studies indexed under Opiate Overdose.
Browse Opiate Overdose studies →University of Colorado, Denver is the lead sponsor of 1,543 studies on the registry; 317 are open to participants now.
Of its 147 completed or terminated interventional studies of FDA-regulated products, 92 (63%) have results posted.
Compared within Opiate Overdose, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Substance-Related Disorders. The counts are of registry records indexed under each term, refreshed daily. How we classify →
Residents and visitors to the state of Colorado who seek healthcare within the University of Colorado Health (UCHealth) primary care system receiving long-term opioid treatment.
Inclusion Criteria: Primary care patients being tapered from an opioid. Tapering patients:
Exclusion Criteria:
Control group to enable tracking of temporal changes in prescribing. Providers will not see any alert.
Other: Observational study without a prospective intervention
observational study without a prospective intervention
Percentage of potential taper-benefit patients
The percentage of chronic opioid primary care patients for which EHR risk indicates tapering may be beneficial
Time frame: 8 months
Observed tapering
The percentage of primary care patients with sustained opioid morphine milligram equivalence (MME) rates declining monthly as an indication of tapering
Time frame: 8 months
Taper magnitude
The percentage of primary care patients with sustained opioid morphine milligram equivalence (MME) rates declining monthly at a rate in line with guideline recommendations
Time frame: 8 months
No study locations are listed for this record.
Plan to share: Yes — De-identified data utilized in this project will be housed on the National Addiction and HIV Data Archive Program (NAHDAP) repository after final study results have been published.
Supporting information: Study protocol
Time frame: Data will be provided to NAHDAP after study results are published in peer-reviewed journals.
Access criteria: Prior to downloading study data, the individual will have to register with the site and agree to a standard data use agreement.
Data sharing details ↗ · www.icpsr.umich.edu
No publications or documents are linked to this record.
Start is estimated for Nov 2026; primary completion for Mar 2027, 4 months later.
Since we started tracking on Sep 25, 2026, the dates moved once, on Sep 30, 2026: start Aug 2026 → Nov 2026 and primary completion Dec 2026 → Mar 2027.
Earlier changes are on the record history on ClinicalTrials.gov ↗
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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University of Colorado, Denver →