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Hypercapnia clinical trials

The registry lists 156 studies for Hypercapnia across more than 10 countries. 31 are recruiting or about to start. 51 of them are mainly about Hypercapnia (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-05.

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A study of drug A after surgery for early breast cancer

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Status

Completed
86
Recruiting
19
Terminated
19
Status unknown
15
Not yet recruiting
10
Withdrawn
5

Phase

Phase 1
9
Phase 3
8
Phase 4
6
Phase 2
6

Where

United States
37
France
15
Germany
13
Italy
10
Spain
10
China
6

Who runs them

Czech Technical University in Prague (6) · Centro Universitario La Salle (4) · IRCCS Azienda Ospedaliero-Universitaria di Bologna (3) · University of Wisconsin, Madison (3) · Vapotherm, Inc. (2) · Assistance Publique - Hôpitaux de Paris (2) · Medical University Innsbruck (2) · National Institutes of Health Clinical Center (CC) (2)

What is being tested here

Drugs under test in Hypercapnia studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

DrugOpenPhase 3All
Caffeine102
Methylphenidate101
Sodium Bicarbonate101
Oxycodone003
Sildenafil002
Morphine012
Paroxetine001
Escitalopram001
Midazolam001
Cebranopadol001

Drug classes tested here Opioids 5

Coming up

4phase 3 studies under way
8studies finish main data collection within a year

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

All 8

Who these studies take

Of the 19 Hypercapnia studies recruiting now, 6 (32%) set no upper age limit and 9 (47%) stop at 75 or younger. 1 (5%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 10 (53%) take healthy volunteers.

Recruiting studies that take each age, of 19
AgeWomenMen
101 (5%)1 (5%)
1817 (89%)17 (89%)
3017 (89%)17 (89%)
4017 (89%)17 (89%)
5017 (89%)17 (89%)
6517 (89%)17 (89%)
7511 (58%)11 (58%)
8510 (53%)10 (53%)

Across all 156 studies, recruiting or not: 36% stop at 75 or younger and 30% at 65; 8% take children; 3% are for women only and 3% for men only; 33% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Hypercapnia studies take

Of 54 interventional studies with no phase under Hypercapnia, half reached primary completion within 14 months of starting, counting those still running.

Start to primary completionEvery sponsorIndustryNon-industry
Interventional, no phase14 mo7–32 · 54 studies—13 mo7–32 · 50 studies

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 11, 2026.

Started recruiting1

Newly registered1

Studies

Recruiting first, then most recently updated. Showing 50 of 156. Browse all 156 → or search them.