An observational study in Thoracic, Surgery and Mechanical Ventilation, sponsored by Laval University. Recruiting at 1 site in Canada. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-11-05.
Sponsored by Laval University · Observational
One-lung ventilation is a mechanical ventilation method frequently used during several thoracic surgeries. One-lung ventilation requires the use of protective ventilation to limit ventilator-induced injury and reduce postoperative respiratory complications. Protective ventilation during one-lung ventilation is specific since tidal volumes are applied by definition to one lung, and it is recommended to use lower tidal volumes, down to 4 ml/kg of ideal body weight. This approach requires individualized ventilation parameters, which differs from the conventional or two-lung ventilation, and there are no clear recommendations regarding respiratory rate adjustment to ensure adequate gas exchange.
The aim of the study is to:
156 studies on the registry are indexed under Hypercapnia; 31 are open to participants now.
This study's planned enrollment of 100 is above the median of 60 across 31 observational studies indexed under Hypercapnia.
Browse Hypercapnia studies →Laval University is the lead sponsor of 380 studies on the registry; 67 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patient undergoing thoracic surgery requiring intraoperative one-lung ventilation
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Patient managed with one lung ventilation
Other: one lung ventilation
Arterial blood gases during one lung ventilation
Respiratory acidosis
The frequency of respiratory acidosis on arterial blood gases after 20 minutes of mechanical ventilation (pH \< 7.35 and PaCO2 \> 45mmHg) measured by arterial blood gases
Time frame: 20 minutes after initiation of one lung ventilation after lung isolation
Respiratory rate
Respiratory rate set by the doctor, this respiratory rate will be compared to the suggestion of the algorithm
Time frame: At the beginning of one lung ventilation during the surgery
Acid-base disorder
Presence of Respiratory alkalosis define by pH\>7.45 and PaCO2 \< 35 mmHg
Time frame: At the beginning of one lung ventilation during the surgery
Number of participants with hemodynamic shock - hypotension
Requiring \>1L of volume repletion and/or use of amines at \>0.05 mcg/kg/min or norepinephrine equivalent
Time frame: Day 1
Hospital length of stay
Recovery room admission through hospital discharge
Time frame: Up to 90 days
Mechanical Ventilation duration
Time spent with invasive mechanical ventilation during surgery and hospital stay
Time frame: Up to 90 days
Hospital mortality
Occurence of death during hospital stay
Time frame: Up to 90 days
Plan to share: No
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.