An interventional study of Hypoxic and Hypercapnic in Hypoxia, Hypercapnia and Cardiac Output, High, sponsored by Czech Technical University in Prague. Completed at 1 site in Czechia. Open to participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-03-11.
Sponsored by Czech Technical University in Prague · Not applicable, Interventional, and Other
The aim of the project is to evaluate the effect of hypercapnia on physiological parameters in a healthy person during short-term hypoxia and hypercapnia.
Hypercapnia causes changes in physiological parameters at various levels throughout the body. The study aims to evaluate the effect of hypercapnia on physiological parameters in a healthy person during short-term hypoxia and hypercapnia. It is an intervention prospective study that will be conducted at the Faculty of Biomedical Engineering on healthy volunteers. All the volunteers undergo three different phases in random order. The individual phases differ in the breathed mixture of oxygen, nitrogen and carbon dioxide gases. Non-invasive measurements of physiological parameters, especially blood oxygen saturation, perfusion index and cardiac output, will be performed continuously during the experiment.
Exclusion Criteria:
Participants inhale ambient air, the hypoxic gas mixture, and ambient air.
Other: Hypoxic
Participants inhale ambient air, the hypercapnic gas mixture, and ambient air.
Other: Hypercapnic
Participants inhale ambient air, the hypoxic and hypercapnic gas mixture, and ambient air.
Other: Hypoxic and Hypercapnic
Hypoxic gas mixture Gas mixture of 10% O2 and 90% N2 for six minutes.
Hypercapnic gas mixture Gas mixture of 21% O2, 5% CO2 74% N2 for six minutes.
Hypoxic and Hypercapnic gas mixture Gas mixture of 10% O2, 5% CO2 85% N2 for six minutes.
Changes in Cardiac output due to the induced hypoxia and hypercapnia
Based on the induced hypoxia, hypercapnia or combination of hypoxia and hypercapnia, Cardiac output will change
Time frame: 1 hour
Changes in Perfusion index due to the induced hypoxia and hypercapnia
Based on the induced hypoxia, hypercapnia or combination of hypoxia and hypercapnia, Perfusion index will change
Time frame: 1 hour
Plan to share: No
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This study is completed, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.
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Czech Technical University in Prague