Dentin Sensitivity clinical trials
The registry lists 288 studies for Dentin Sensitivity across more than 10 countries. 46 are recruiting or about to start. 255 of them are mainly about Dentin Sensitivity (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-30.
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Status
Who runs them
GlaxoSmithKline (28) · HALEON (21) · Universidade Federal do Para (19) · Cairo University (17) · Procter and Gamble (11) · Universidade Federal Fluminense (8) · Colgate Palmolive (7) · University of Sao Paulo (7)
What is being tested here
Drugs under test in Dentin Sensitivity studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026Real-World Study of a Calcium Sodium Phosphosilicate Anti-Sensitivity Toothpaste for Dentin Hypersensitivity Relief · HALEON
- Dec 2026Evaluation of Different Non-Invasive Methods in the Treatment of Dentin Hypersensitivity Associated With Non-Carious Cervical Lesions: A Split-Mouth Clinical Study · Cukurova University
- Dec 2026Clinical Evaluation of Short Dentin Etching · Mansoura University
- Jan 2027A Study to Assess the Efficacy of a Calcium Sodium Phosphosilicate Toothpaste for the Relief of Dentine Hypersensitivity · HALEON
- Feb 2027A Study Evaluating Oral-Health-Related Quality of Life and Treatment Patterns Among Dentin Hypersensitivity Sufferers · HALEON
- Mar 2027A Clinical Study to Assess the Efficacy of a Calcium Sodium Phosphosilicate Toothpaste for the Relief of Dentine Hypersensitivity · HALEON
- Apr 2027Effectiveness of Two Different Desensitizing Dental Varnishes · Ivoclar Vivadent AG
- May 2027Dentine Hypersensitivity Using Dentine Adhesive With Strontium-doped Bioactive Glass-Ceramic · The University of Hong Kong
- Jun 2027Diode Laser Plus CPP-ACPF vs CPP-ACPF Alone for Dentin Hypersensitivity · Cairo University
- Jul 2027Modified Coronally Advanced Tunnel for Mandibular Lingual Root Coverage · University of Pittsburgh
Who these studies take
Of the 18 Dentin Sensitivity studies recruiting now, 6 (33%) set no upper age limit and 11 (61%) stop at 75 or younger. 1 (6%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 11 (61%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (6%) | 1 (6%) |
| 18 | 14 (78%) | 14 (78%) |
| 30 | 16 (89%) | 16 (89%) |
| 40 | 15 (83%) | 15 (83%) |
| 50 | 13 (72%) | 13 (72%) |
| 65 | 12 (67%) | 12 (67%) |
| 75 | 7 (39%) | 7 (39%) |
| 85 | 7 (39%) | 7 (39%) |
Across all 288 studies, recruiting or not: 75% stop at 75 or younger and 60% at 65; 9% take children; <1% are for women only and 0% for men only; 72% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Dentin Sensitivity studies take
Of 14 phase 4 interventional studies under Dentin Sensitivity, half reached primary completion within 2 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 3 | 7 mo3–14 · 13 studies | — | — |
| Phase 4 | 2 mo2–15 · 14 studies | — | — |
| Interventional, no phase | 6 mo3–10 · 144 studies | 3 mo2–6 · 33 studies | 7 mo4–12 · 111 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Started recruiting1
Results posted1
Newly registered3
- A Study to Assess the Efficacy of a Calcium Sodium Phosphosilicate Toothpaste for the Relief of Dentine HypersensitivityOct 26, 2026NCT07894796
- 450 nm Blue Diode Laser Versus Blue LED for In-Office Tooth BleachingOct 13, 2026NCT07870317
- Efficacy of a Sonic Toothbrush and 8% Arginine Toothpaste in Reducing Dentinal HypersensitivityOct 13, 2026NCT07871786
Studies
Recruiting first, then most recently updated. Showing 50 of 288. Browse all 288 → or search them.
- A Study to Assess the Efficacy of a Calcium Sodium Phosphosilicate Toothpaste for the Relief of Dentine HypersensitivityRecruitingNCT07894796Not applicable1 country
- Dentine Hypersensitivity Using Dentine Adhesive With Strontium-doped Bioactive Glass-CeramicRecruitingNCT07628712Not applicable1 country
- A Clinical Study to Assess the Efficacy of a Calcium Sodium Phosphosilicate Toothpaste for the Relief of Dentine HypersensitivityNot yet recruitingNCT07802886Not applicable1 country
- Effectiveness of Two Different Desensitizing Dental VarnishesRecruitingNCT07622043Not applicable1 country
- Comparative Efficacy of Different Dentin Occluding Toothpaste TechnologiesRecruitingNCT07664592Phase 31 country
- Modified Coronally Advanced Tunnel for Mandibular Lingual Root CoverageEnrolling by invitationNCT07590960Not applicable1 country
- Effect of Bleaching Regimen With Different Activation Modes on Color Stability, Surface Roughness, Tooth Sensitivity and Patient SatisfactionEnrolling by invitationNCT07493941Not applicable1 country
- Evaluation of Different Non-Invasive Methods in the Treatment of Dentin Hypersensitivity Associated With Non-Carious Cervical Lesions: A Split-Mouth Clinical StudyNot yet recruitingNCT07648147Not applicable1 country
- Effect of Fluoride Varnish Formulation on the Management of Dentin HypersensitivityRecruitingNCT07286344Not applicable1 country
- Multi-site Study to Look at Tooth Wear and Tooth Sensitivity and the Risk Factors Associated.RecruitingNCT071953571 country
- A Study Evaluating Oral-Health-Related Quality of Life and Treatment Patterns Among Dentin Hypersensitivity SufferersRecruitingNCT073371091 country
- Hydroxyapatite-Based Home Treatment for Dentin Sensitivity in Celiac PatientsRecruitingNCT07069127Not applicable1 country
- Dipotassium Oxalate for Postoperative Sensitivity in NCCLsNot yet recruitingNCT07540299Not applicable1 country
- Effectiveness of Dental Bleaching Using Different Designs of 3D-Printed and Conventional Customized NightguardsRecruitingNCT07464197Not applicable1 country
- Diode Laser Plus CPP-ACPF vs CPP-ACPF Alone for Dentin HypersensitivityNot yet recruitingNCT07449169Not applicable
- Hydroxyapatite Toothpastes and Enamel Remineralization:RecruitingNCT07069218Not applicable1 country
- Graphene-Reinforced CAD/CAM Restorations for MIH-Affected Molars in Adolescents: A Prospective Clinical StudyNot yet recruitingNCT07329244Not applicable1 country
- Gluma Compared With Bonding Agent for Post-operative Sensitivity Following Composite RestorationsNot yet recruitingNCT07188142Phase 2/31 country
- The Effect of Bleaching Application Mode on Bleaching-induced Tooth Sensitivity.RecruitingNCT07173296Not applicable1 country
- Comparative Efficacy of Laser Systems and Fluoride in Managing Dentinal Hypersensitivity: RCTNot yet recruitingNCT07141576Not applicable
- Clinical Effectiveness of Episodic Use of Bioactive Silica Based Versus in Management of Dentin Hypersensitivity (A 6m Randomized Clinical Trial)Not yet recruitingNCT07120139Not applicable1 country
- BIOSILITACE AS A DESENSITIZING AGENTIN HMINot yet recruitingNCT07080645Not applicable1 country
- Three Different Topically Applied Materials as Non-invasive Treatment of Sensitivity in Permanent Teeth With Molar Incisor HypomineralizationNot yet recruitingNCT07056855Not applicable
- Effect of an Experimental Cannabidiol Gel on Tooth SensitivityNot yet recruitingNCT07027566Phase 11 country
- Effectiveness of Calcium Silicate and Sodium Fluoride Nanoparticles in The Management of Dentin HypersensitivityNot yet recruitingNCT06557980Not applicable
- Evaluation of the Combined Effect of Bioactive Toothpastes, Desensitizing Agents and Er-YAG Laser on Dentin Hypersensitivity: an In-Vivo StudyNot yet recruitingNCT06854068Not applicable
- Exposed Hypersensitive Dentin Treated with Fluoride Iontophoresis with Remineralizing AgentsEnrolling by invitationNCT06837779Not applicable1 country
- Using Calcium Hydroxylapatite to Treat Gum Recession and Tooth HypersensitivityEnrolling by invitationNCT06826391Not applicable1 country
- Efficacy of a Potassium Nitrate Containing Herbal Mouthwash to a Potassium Oxalate Mouthwash in Dentinal HypersensitivityRecruitingNCT06627790Phase 31 country
- Efficacy and Safety Assessment of Experimental Bleaching AgentsNot yet recruitingNCT06802614Not applicable1 country
- Photobiomodulation and New Restorative Material for Teeth With MIH on Control of Hypersensitivity and LongevityNot yet recruitingNCT06538142Not applicable
- Efficacy of Tooth Bleaching With 35% and 6% Hydrogen Peroxide in Primary DentitionNot yet recruitingNCT05789004Phase 1/2
- Neurological Responses in Patients with Dentine HypersensitivityRecruitingNCT066336271 country
- Dentine Hypersensitivity Management KAP StudyEnrolling by invitationNCT065822381 country
- Dentin Hypersensitivity - Varnish or Laser?Not yet recruitingNCT06539286Not applicable
- A Clinical Trial to Compare Lasotronix Alone or in Combination With CPP-ACP to Treat DHRecruitingNCT06463938Not applicable1 country
- Efficacy of Formulated Eggshell Derived Nano-hydroxyapatite Containing Toothpaste With and Without Addition of Fluoride vs. Conventional Desensitizing Fluoride Containing Toothpaste in Management of Dentin HypersensitivityNot yet recruitingNCT06493500Phase 1
- Effect of Pregabalin Gel in Controlling Cervical Dentin HypersensitivityNot yet recruitingNCT06417580Phase 2
- The Effect of Using Desensitizers Containing S-PRG In Treatment Of Dentin Hypersensitivity Over 6 Months: A Randomized Clinical TrialNot yet recruitingNCT06276777Not applicable1 country
- Reduction of Dentine Hypersensitivity After Use of Different DentifricesRecruitingNCT06273930Phase 11 country
- Dentine Hypersensitivity Treated With Laser and Fluoride.Enrolling by invitationNCT06202495Not applicable1 country
- Pregabalin Gel in Reducing Post-operative Tooth Sensitivity Surgery Caused by Bleaching With 35% Hydrogen PeroxideNot yet recruitingNCT06180707Phase 31 country
- Clinical Evaluation of Giomer Based Varnish Versus CPP-ACP Varnish in the Management of Dentin Hypersensitivity: a Randomized Clinical TrialRecruitingNCT06154941Not applicable1 country
- Managing Dentine Hypersensitivity With Silver Diamine Fluoride on Older AdultsRecruitingNCT05392868Phase 21 country
- Grape Seed Extract VS Low Level Laser Therapy for Dentin HypersensitivityRecruitingNCT05927831Not applicable1 country
- Comparison of the Effectiveness of Self Etch Adhesive and Fluoride Varnish in Reducing Hypersensitivity in Patients With Gingival RecessionNot yet recruitingNCT05895526Not applicable1 country
- Phase 2 Study of KH001 in Long-term Relief From Dentin HypersensitivityCompletedNCT06464939Phase 21 country
- Laser Therapy for Dentin HypersensitivityCompletedNCT07431736Not applicable1 country
- Clinical Comparison of CAD/CAM Nanohybrid Composite and Hybrid Ceramic Overlays in Children With Molar-Incisor HypomineralisationCompletedNCT06987448Not applicable1 country
- Clinical Evaluation of Short Dentin EtchingActive, not recruitingNCT06772051Not applicable1 country