An interventional study of Diode laser photobiomodulation combined with CPP-ACPF varnish and CPP-ACPF varnish in Dentin Hypersensitivity and Tooth Hypersensitivity, sponsored by Cairo University. Not yet recruiting. Open to participants aged 20 Years to 50 Years. Per ClinicalTrials.gov, last updated 2026-03-04.
Sponsored by Cairo University · Not applicable, Interventional, and Treatment
This study aims to compare the effectiveness of diode laser photobiomodulation combined with CPP-ACPF varnish versus CPP-ACPF varnish alone in reducing dentin hypersensitivity. Participants diagnosed with dentin hypersensitivity will receive either the combined treatment or varnish application alone. Pain levels will be evaluated using a standardized visual analog scale before and after treatment sessions. The results of this study may help determine whether adding diode laser therapy enhances the effectiveness of conventional varnish treatment in managing dentin hypersensitivity.
This study is a clinical trial designed to evaluate the effectiveness of two treatments for dentin hypersensitivity, which is the pain or discomfort felt when teeth are exposed to hot, cold, sweet, or touch.
Participants who meet the study criteria will be randomly assigned to one of two groups:
Group A: Treatment with a diode laser combined with CPP-ACPF varnish applied to the sensitive teeth.
Group B: Treatment with CPP-ACPF varnish alone.
Study Procedures:
Screening and Enrollment: Participants will undergo a dental examination to confirm they have sensitive teeth. Medical history and consent will be collected.
Baseline Assessment: Pain sensitivity will be measured using a simple pain scale to record how severe the sensitivity is before treatment.
Treatment: The assigned treatment will be applied to the sensitive teeth. The laser procedure is painless and safe, and the varnish is a commonly used dental material.
Follow-Up Visits: Participants will return for follow-up assessments immediately after treatment, after one month, after three months, and after six months. Pain sensitivity will be measured at each visit to track changes over time.
Safety and Monitoring:
The procedures are safe, and side effects are expected to be minimal.
Any discomfort or unexpected reactions will be addressed promptly by the dental team.
Participants can withdraw from the study at any time without affecting their standard dental care.
Purpose of the Study:
The goal is to determine whether combining diode laser treatment with CPP-ACPF varnish is more effective at reducing tooth sensitivity than using the varnish alone. The results may help dentists provide the best treatment options for patients with sensitive teeth in the future.
288 studies on the registry are indexed under Dentin Sensitivity; 46 are open to participants now.
This study's planned enrollment of 70 is above the median of 60 across 279 interventional studies indexed under Dentin Sensitivity.
Browse Dentin Sensitivity studies →Cairo University is the lead sponsor of 4,941 studies on the registry; 1,458 are open to participants now.
Of its 37 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
An allergy, or another reaction of the immune system, to a substance. “Hypersensitivity to the study drug” means a known allergic reaction to it — not every side effect a medicine can have.
Hypersensitivity
An allergy, or another reaction of the immune system, to a substance. “Hypersensitivity to the study drug” means a known allergic reaction to it — not every side effect a medicine can have.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants will receive diode laser treatment combined with CPP-ACPF varnish on sensitive teeth.
Device: Diode laser photobiomodulation combined with CPP-ACPF varnish
Participants will receive CPP-ACPF varnish alone on sensitive teeth.
Other: CPP-ACPF varnish
Participants will receive diode laser photobiomodulation applied to sensitive teeth followed by application of CPP-ACPF varnish according to the manufacturer's instructions. This combination treatment is intended to reduce dentin hypersensitivity.
Also known as: Diode laser therapy, Low-level laser therapy (LLLT), photobiomodulation, PBM
Participants will receive CPP-ACPF varnish applied to sensitive teeth according to the manufacturer's instructions to reduce dentin hypersensitivity.
Also known as: Casein phosphopeptide-amorphous calcium phosphate fluoride varnish
Reduction in dentin hypersensitivity in response to evaporative (air-blast) stimulus
Change in dentin hypersensitivity in response to an evaporative (air-blast) stimulus, measured using a visual analog scale (VAS). Lower scores indicate reduced sensitivity. Scores: 0-10 (Ordinal) where 0 represents "no pain" and 10 represents "greatest pain".
Time frame: Assessed at baseline, immediately post-treatment, and at 1 month, 3 months, and 6 months follow-up.
Reduction in dentin hypersensitivity in response to tactile (dental probe) stimulus.
Change in dentin hypersensitivity in response to a tactile stimulus using a dental probe, measured with a visual analog scale (VAS). Lower scores indicate reduced sensitivity. Scores: 0-10 (Ordinal) where 0 represents "no pain" and 10 represents "greatest pain".
Time frame: Assessed at baseline, immediately post-treatment, and at 1 month, 3 months, and 6 months follow-up.
No study locations are listed for this record.
Plan to share: Undecided
No publications or documents are linked to this record.
Start is estimated for Apr 2026; primary completion for Jun 2027, 14 months later.
Of 111 non-industry interventional studies with no phase under Dentin Sensitivity, half reached primary completion within 7 months of starting (the median), counting those still running; a quarter within 4 and three quarters within 12. This study's planned 14 months is above that.
Counting every sponsor, half of 144 studies reached it within 6 months; a quarter within 3 and three quarters within 10.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.
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