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Enrolling by invitationNCT06202495Updated Feb 20, 2024

Dentine Hypersensitivity Treated With Laser and Fluoride.

An interventional study of Laser and Fluoride and Fluoride in Sensitive Dentin, sponsored by University of Pavia. Enrolling by invitation at 1 site in Italy. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-02-20.

Sponsored by University of Pavia · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
43
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

The aim of the present report is to evaluate the amino fluoride gel with or without application of diode laser on pain due to dentine hypersensitivity.

NRS (numerical rating scale) index will be used to evaluate the pain suffered by each patient after cold air blow stimulus.

After treatment application, the follow-up timing planned for each patient will be at 1 week, 1 month, 3 months and 6 months

Read the detailed description

The aim of the present report is to evaluate the amino fluoride gel with or without application of diode laser on pain due to dentine hypersensitivity.

The study is designed with a split mouth design. NRS (numerical rating scale) index will be used to evaluate the pain suffered by each patient. The pain response will be stimulated by thermal urge (cold air blow). Teeth will be divided in two groups. The treatment group, treated with 980nm diode laser and amino fluoride gel; the control group, treated only with amino fluoride gel.

The follow-up timing planned for each patient will be at 1 week, 1 month, 3 months and 6 months. In these follow-up sessions a revaluation of the pain response is performed using the NRS index.

02

Conditions studied

  • Sensitive Dentin

Keywords

  • Dentine hypersensitivity
  • fluoride
  • laser
03

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Teeth in good periodontal health
  • Good oral hygiene
  • Dentine hypersensitivity: NRS (Numerical Rating Scale) ≥ 3

Exclusion criteria

Exclusion Criteria:

  • Teeth local disease or fractures in treatment area
  • Irreversible teeth necrosis or pulpitis
  • Definitive restorations or veneers
  • Recent use of painkillers or anti-inflammatory drugs,
  • Treatment for dentine Hypersensitivity less than 6 months before the study start
  • Therapies contraindication
04

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Triple (Participant, Investigator, Outcomes assessor)
Enrollment
43 participants (estimated)

Study arms

  • Experimental
    Laser and Fluoride

    The treatment group will be treated with amino-fluoride gel (Elmex Dental Gel, Colgate-Palmolive company, New York, 300 Park Ave, United States) in association 980nm diode laser (doctor smile wiser by Lambda s.p.a. Via dell'Impresa, 1, 36040 Brendola VI, Italy) 1.5 W, pulsed mode 2 mm from tooth surface. For treatment will be used 400 μm diameter and 5 mm long tips of for 4 minutes

    Device: Laser and Fluoride

  • Active comparator
    Fluoride

    The control group will be treated with amino-fluoride gel (Elmex Dental Gel, Colgate-Palmolive company, New York, 300 Park Ave, United States) for 4 minutes.

    Other: Fluoride

Interventions

  • DeviceLaser and Fluoride

    topic application of amino-fluoride gel (Elmex Dental Gel, Colgate-Palmolive company, New York, 300 Park Ave, United States) in association 980nm diode laser (doctor smile wiser by Lambda s.p.a. Via dell'Impresa, 1, 36040 Brendola VI, Italy) 1.5 W, pulsed mode 2 mm from tooth surface

  • OtherFluoride

    topic application of amino-fluoride gel (Elmex Dental Gel, Colgate-Palmolive company, New York, 300 Park Ave, United States)

05

What researchers measure

Primary outcomes

  1. NRS (numerical rating scale)

    The dentine hypersensitivity will be evaluated with the Numerical Rating Scale ( NRS ), where 0 meant pain absence and 10 a unbearable pain (Hjermstad MJ, Fayers PM, Haugen DF, Caraceni A, Hanks GW, Loge JH, et al. Studies comparing Numerical Rating Scales, Verbal Rating Scales, and Visual Analogue Scales for assessment of pain intensity in adults: a systematic literature review. J Pain Symptom Manage. 2011;41(6):1073-93.)

    Time frame: Before treatment and 1 week, 1 month, 3 months, 6 months after treatment

06

Study locations

1 site
  • A.O. Mater Domini, U.O. Odontoiatria, University of Catanzaro "Magna Græcia".
    Catanzaro, Italy
07

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT06202495
Lead sponsor
University of Pavia
Responsible party
Andrea Scribante (Professor, University of Pavia) — Principal investigator
First posted
Jan 11, 2024
Start date
Jan 15, 2024
Primary completion
Jul 5, 2024 (estimated)
Completion
Jul 10, 2024 (estimated)
Last update
Feb 20, 2024

Study contacts

Andrea Scribante, DDS PhD MSc
principal investigator · Unit of Dental Hygiene - Section of Dentistry - Dep of Clin Surg Diagn Ped Sci - University of Pavia

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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